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I should have loved biology (2020)

lordnacho
23 replies
9h26m

There's too much focus on the "what we know" like Kreb's cycle, which is easily examinable. The focus should actually be "how we found out", something like what the book A Brief History of Everything traces out. Things like "we used isotopes with different masses to figure out this thing about phosphorous in DNA".

In general, the "what" makes no sense without the history. Why were we searching for DNA in the mid 20th century? What did we already know? Retracing science as an investigation would be much more beneficial to kids than making them remember the conclusions. It's much more portable as a skill to understand the path of investigation than some facts about organelles that they aren't likely to use.

But the real reason I dropped biology when the choice came (and why did it come, dear IB organisation?) is that biology is not seen as the smart kid subject, when compared to physics and chemistry. Part if this is that you can grind your way through memorizing the biochemical cycles, probably easier for most than learning calculus that you need for physics. But part of it is simply reputation, and it's not reasonable.

I have a friend who is a postdoc stats guy in the biology field. There's actually a deep need for numeracy in biology, people just don't seem to know it when they're in school.

Lutzb
7 replies
5h20m

This is why history resonated so well with me back in school. Instead of just blindly learning historical facts our teachers requested us to explain what were the grounds and cause of historical events.

I still use this when learning new concepts. I try to Llearn what existed before and why the change made sense.

Jensson
5 replies
5h15m

So instead of memorizing facts you were asked to memorize someone's theories, is that really better? To me that was always much worse.

zamadatix
4 replies
5h7m

Knowing some of the potential whys and using them to try to explain the following event is a lot more than just memorizing someone else's theory, it's learning to piece together an understanding from information. Even if you don't ultimately agree with "someone else's theory" (say, the common take) you should be able to understand why others think it then add in your arguments of what you think. Any of this is better than wrote memorization.

Jensson
3 replies
4h50m

Any of this is better than wrote memorization.

This is rote memorization.

you should be able to understand why others think it then add in your arguments of what you think

This isn't what you have to do on the tests however, the tests just wants you to repeat the theory from the book, or the theory from your teacher. Many seem to just adopt others theories as their own in such scenarios so people who do that might like it, but anyone who thinks for themselves will hate that since you quickly realize this is just another "memorize this thing" situation but you have to write it as if you buy into the theory.

zamadatix
2 replies
3h47m

Rote memorization isn't "any time you remember a fact" it's when you solely use repeated memorization to learn something. Discussing the why's and forming an explanation with the content and other things at the time is active/meaningful/associative learning (those are 3 different types of learning from rote memorization, not an ad hoc description).

I'd agree this isn't what you do on a normal test. It didn't sound like GP was arguing these points in a normal test, nor does a normal test match 95% of my APUSH experience either even though that ended in a standardized test.

Sure, you can find some worst case of student and worst case of teacher where this can devolve into being no better than raw memorization. Hopefully you can at least imagine other scenarios are possible too.

Jensson
1 replies
3h22m

You do realize the books already talks a lot about why? All subjects already include so many whys that students just filters it out, people just fondly remember the few subjects where they didn't filter out all the interesting parts.

The result is that students just memorize the whys, sure you can always go beyond that and have fun in every class but that has very little to do with the teacher bringing it up, because the teachers brings that up in almost every class or at least the books does. So, that they focused on why is still rote memorization just like the focus on facts, sure facts do tell an interesting tale but if people ignore that and just memorize the facts then they aren't any fun. It is the same way with looking at "why", it is just a bunch of facts in the end and most students makes that boring.

Sure, you can find some worst case of student and worst case of teacher where this can devolve into being no better than raw memorization

No, that is the normal case, almost everyone here did this which is why they have so horrible memories from school. You too probably did this, memorized stuff when the teacher desperately tried to get you to engage with it in more interesting ways, otherwise you wouldn't have thought it is so rare for such teaching to fail, because if you really saw all the teachers that tried you couldn't have had that opinion since you'd see all your classmates zone out and be bored and ask for rote memorization details.

I've never ever seen a schoolbook that was just a list of facts, it just isn't a thing, students still doesn't engage.

zamadatix
0 replies
3h12m

Books often give some of the "why" but that's different from a method which engages with the why. The main change is in going from passively interacting with the material "In the book it says... in my notes it says... in class it was said... on the test it wanted me to recall..." to actively interacting with the material "the book had these why's... the teacher/we discussed these why's... i need to be able to defend the argument of why... I also think... on the test I argued why the fact occurred". Even personally bored while doing it or not it's a better way to learn the material.

You do memorize why's but part of arguing the why's, either to the teacher or in groups, is to add interaction with the details. It may or may not be a barrel of fun but it is, by definition, more engaging. Whether or not that's a personal case is going to be subjective but yes, most people really do like learning via more than rote memorization alone all the time in lieu of mixing it up and engaging on average.

I've definitely had classes where the teacher wasn't able to make the content interesting/engaging - it sucked either way in that case. I'm not as sure the teaching "fails" as much as is "not as good". That students zone out is no measure of a method being universally bad, that the method is single approached and almost all students zone out is a good indicator though and that's what you get with constant memorization only.

lotsofpulp
0 replies
5h2m

While the motivation is correct, I would have to take this with a huge boulder of salt due to the inability to accurately obtain and analyze all the information around the historic event.

Etherlord87
6 replies
8h42m

As a safety inspector, I find to be more successful in teaching safety when I explain why some rules are in place. If not explained explicitly, people will figure an explanation on their own, and then sometimes they will be wrong - e.g. I'm safe to enter the hazardous zone, as it's a break time so no one works above = no risk of things falling down - except some things could be poorly secured and still fall down, or there could be a radiographic testing pending, or there could be holes in the floor… Knowing the reasons for a rule also make it easier to remember the rule.

kstrauser
3 replies
5h17m

I wish more people understood your thinking. Two instructions you get at a doctor’s office before having a surgical procedure:

- Wear comfortable clothes.

- Don’t eat anything before surgery.

The first is so you don’t have tight clothes rubbing your achy body on the ride home. The second is so that you don’t vomit up your eggs Benedict, inhale it, and die an awful death. They’re both in the same size print in the same bullet list.

That stuff should be explained beforehand but I rarely hear it said that concretely. I’ve wondered if rephrasing that like:

- Don’t eat anything before surgery, because it might make you die.

would save lives.

Jensson
1 replies
4h17m

I’ve wondered if rephrasing that like: ... would save lives

It would make people more scared of surgeries since the wording is stronger, fear of surgeries causes a lot of issues as well including people dying since they refuse to get a surgery.

kstrauser
0 replies
2h0m

Fair. Maybe they could be in separate sections like “For your comfort” and “Critical safety instructions”. The broader idea is that people should know the gist of why they’re being told not to do a thing, and that it’s for their own good. In this case the instruction isn’t to avoid them puking so that a janitor doesn’t have to clean it up (along the same lines of “no black rubber soles on the gym floor”), but so it doesn’t put them in intensive care.

NoMoreNicksLeft
0 replies
2h12m

Humans spent the last 40,000 years not having explanations for rules because there were no (known) explanations for rules. Not an easy habit to shake, I think.

red-iron-pine
1 replies
3h43m

I work in train and aviation operational systems. We do safety training by taking teams to depots or sites of accidents where there are ruined systems.

Seeing the remains of an aircraft fuselage, or what a burned out diesel locomotive looks like -- and in the case of the train, smells like; it was being repaired -- really drives the point home.

A couple more slides on case studies and how they happened -- shout out of Admiral Cloudberg for doing a great job with that stuff; use their articles a lot -- and it's easy to convince people. Make it visceral, and they sure as hell will remember.

Presumably it's the same with a lot of science education as well. Physics and math for the sake of math is just rote memorization, but make them calculate rocket trajectories, then build a few model rockets and shoot them off, and those kids will be way more engaged. Like, I got really into biology when I started making basement hooch in college...

heymijo
0 replies
2h54m

Tremendous comments in this thread that exemplify something I enjoy about HN, generative consumption. That's a fancy way of saying certain posts and comments get my mental wheels spinning, which I can transfer to whatever else I'm doing for the day.

Five minutes here for the blog, your comments, this reply, then I'm out and likely more productive than I was 6 minutes ago.

jonplackett
4 replies
8h59m

I had this same experience being taught physics and maths. Just a bunch of what feel like pretty dull experiments which ends with a gold leaf moving...

But the STORY of physics is fascinating. Why each experiment was done, by who, to prove what etc etc. All the sciences are like a soap opera of personalities and disagreements that make them much more interesting - and memorable - if you know the back story.

That 'thin deep slice' comment really sums it up. No context, just a thing to memorise.

I think physics students should be give The Fabric of the Cosmos my Brian Greene to read before they start doing any actual learning. I bet there's a biology equivalent of a book that is a 'what we know so far and what we don't understand' - if you know of one please let me know.

Jensson
2 replies
5h20m

All the sciences are like a soap opera of personalities and disagreements that make them much more interesting

Most people don't like soap operas and would zone out due to that, you might get a different set of people interested but you wouldn't get more.

mikea1
1 replies
5h6m

I took gp's use of "opera" to describe an inclusive, wide range of genres that feature human relationships, like space operas. There's definitely mass appeal (think of Star Wars alone.)

Jensson
0 replies
4h38m

If you took star wars and removed the action and acting and it was just a bunch of philosophical arguments written in a book then not many would like it. We know since there are many such books and they aren't very popular compared to the star wars movie.

philsnow
0 replies
1h46m

I had this same experience being taught physics and maths. Just a bunch of what feel like pretty dull experiments which ends with a gold leaf moving...

But the STORY of physics is fascinating.

There’s a college some of my kids have been considering that takes a similar approach to their math (and sciences) curricula, starting math out with Euclid and progressing through Ptolemy, Copernicus, and Kepler (maybe Leibniz / Newton? Not sure), at each point motivating the development of astronomy and mathematics by showing how each person developed our understanding of the natural universe.

In comparison, in my college math courses, which were oriented towards engineering majors, I felt at the time like concepts were coming out of nowhere without justification, with no sense of how they fit in with anything else, other than the certainty that I had to keep up or I would be lost a week later.

aleph_minus_one
1 replies
4h52m

There's too much focus on the "what we know" like Kreb's cycle, which is easily examinable. The focus should actually be "how we found out", something like what the book A Brief History of Everything traces out.

The problem is that in school there is far too little time to teach this all. There is already too little time to teach the curriculum material. Thus, if you are interested in such topics, simply go to a decent (university) library.

giogadi
0 replies
4h43m

I think we could reduce the scope of today's curricula to accommodate this kind of teaching. If students spent a few more months understanding the how of scientific discovery instead of the what, I think it would be a worthwhile trade-off.

globular-toast
0 replies
8h21m

When I crammed virology before taking a computational biology role, the "how we know" was the most fascinating part for me. I suddenly understood science and realised I'd spent 20 years of my life learning facts, called "science", but not actually understanding science at all.

A great example is the Hershey-Chase experiment[0]. What I realised is science isn't about learning and memorising facts, it's a creative process of prodding the universe in just the right way to learn something about it. I realised scientists have more in common with artists than engineers and that I am definitely more of an engineer.

[0] https://en.wikipedia.org/wiki/Hershey%E2%80%93Chase_experime...

echelon
22 replies
21h54m

I should have loved biology but I found it to be a lifeless recitation of names: the Golgi apparatus and the Krebs cycle; mitosis, meiosis; DNA, RNA, mRNA, tRNA.

You just had bad teachers. The subject is all at once beautiful, bizarre, fascinating, daunting, mysterious, majestic, labyrinthine, and awe-inspiring.

We are solutions along a physical, biogeochemical optimization gradient. We're fit to the world around us like a glove.

We're also distributed systems. Every sub-component of every single one of our cells is a computational system in flux, dynamically adjusting to trillions of inputs every single second.

Even the packing of "junk DNA" is a calculated encoding of spatiotemporal expression dynamics and far downstream behavior.

We are the universe encoding behavior unto itself. Exchanging gasses, assembling polymers, replicating, carefully kept in balance. Battling against other systems attempting to utilize the same energy gradients.

I think we also need inspiration. There is a romance in biology, as in any other science, that a movie like Good Will Hunting could bring out. We need heroes. Whoever delivers us from this pandemic in the form of a slam dunk vaccine, or a cheap quick reliable test, should become a household name, not for their own glory but for our kids—a Feynman for them to dream about someday becoming.

Biology doesn't have the rockets or the fancy computers, but it stands to one day unlock some of the best things for humanity: a world free of diseases, long lives, and perhaps one day, even immortality.

The only reason it's not sexier is that it's still in the punch card phases. We're just starting to scratch the surface of the computers that make up ourselves.

ArtsiomH
20 replies
21h45m

You just had bad teachers. The subject is all at once beautiful, bizarre, fascinating, daunting, mysterious, majestic, labyrinthine, and awe-inspiring.

This. I'd say it applies to a lot, If not all subjects.

In my experience teachers rarely explained, why we need the subject, and what's it's use. Now I see myself digging thing on my own, and realising how cool a lot of subjects are.

jononomo
18 replies
21h42m

No. Biology is unique in the sense that life is the creation of God and is far more complex and awe-inspiring than any other subject.

Jerrrry
13 replies
21h39m

Newton remarked that what colors leaves green would always be a mystery to all but our great Creator, Jesus Christ, the father.

Turns out, its chlorophyll.

https://en.wikipedia.org/wiki/God_of_the_gaps

jononomo
12 replies
20h3m

Yes, I bite the bullet on the God of the Gaps. What I object to is materialism of the gaps. At least God has explanatory power. Materialism does not.

pfdietz
7 replies
19h15m

God has explanatory power

For a hypothesis to have explanatory power, it must be falsifiable. Otherwise, it's compatible with literally anything and hence can explain nothing.

What observation in your mind would falsify the existence of God?

mistermann
4 replies
18h22m

Otherwise, it's compatible with literally anything

and hence can explain nothing.

Could you explain your reasoning here?

esafak
2 replies
16h0m

Otherwise you can't test it, for one. It is easy to concoct all-encompassing explanations that can't be proven wrong. Here's one I just made up: instead of one god, there is a pantheon of gods. And a different one for each universe. Ours is governed by the Norse league. Prove me wrong.

https://en.wikipedia.org/wiki/Falsifiability

dl9999
1 replies
8h21m

I think unguided natural processes plus deep time plus multiverses could also be an all-concompassing explanation that can't be proven wrong.

mistermann
0 replies
3h51m

Even more fundamental: anything ~false built on top of Naive Realism can exist indefinitely not just undiscovered to be false, but cannot even be identified as a candidate for consideration.

Let's hope we don't have this problem here on planet Earth, and especially at a core, fundamental level(s)!

pfdietz
0 replies
16h18m

An explanation for why X is true must also be an explanation of why not X is false. But God could perfectly well explain why not X is true and X is false. If God has no predictive power, if it's consistent with anything, it can't be used to distinguish between any possibilities, and hence can't explain why they should hold.

mistermann
0 replies
14h50m

I have a feeling you just made the stories below up.

Could you refer to an existing proof of these claims, or at least put it in some sort of a more logical form that can demonstrate that these things are necessarily true? Narrative format can make not actually true things appear true pretty easily.

jononomo
0 replies
4h16m

Then falsify my hypothesis by coming up with some plausible materialistic mechanism to account for the existence of life.

SturgeonsLaw
3 replies
19h12m

Supernatural forces are a lazy explanation and don't offer any true insight. They have been invoked time and time again, and there has always been a natural explanation for phenomena that were once attributed to God(s). It's an intellectual dead end.

jononomo
2 replies
4h14m

I disagree. I think that life is a unique case.

Jerrrry
1 replies
3h8m

What you consider "Life" is just an awe-inspiring amount of complexity that has irked out an existence in the small, brief gradient of temperature our universe has permitted.

The clouds of Jupiter, when viewed from a planetary scale, have a similar amount of [apparent] complexity.

We simply bias familiar complexity due to our evolutionary pathway.

A planet-sized fungal-like Gaia creature that "eats" clouds by atmospheric manipulation and is able to seed it's lower planetary orbit with proto-replicative molecules would scuff at such a self-centered bias.

jononomo
0 replies
12m

Can you think of anything that might distinguish the complexity of life from the complexity of the clouds of Jupiter? Or do you think life is simply a nonsense concept?

echelon
3 replies
21h34m

I think it's far more likely that we're the simulation of some super intelligence than the creation of a mythological deity worshiped by ancient goat herders.

But to each simulant, their own programming. Unicuique suum.

jononomo
1 replies
20h2m

You realize that those two ideas are identical, right? RIGHT??

mistermann
0 replies
18h19m

Can you copy paste in your implementation of equals()? My spider senses tell me there is a bug contained within.

willy_k
0 replies
18h28m

What do we call the people who created the simulation? Is it unreasonable that they would give us stories to impose their own morals on us? Maybe they have a punishment or a reward for you depending on your qualities, such as getting to live in the host universe or getting stuck in an undesirable environment.

I’m more partial to God being Humans that survived the flood (being real and caused by an asteroid exploding over ice caps) and have been chilling underwater, occasionally popping their UAPs up and poking around. But I don’t hold that view too firmly.

ReleaseCandidat
0 replies
21h18m

In my experience teachers rarely explained, why we need the subject, and what's it's use.

That's exactly the opposite of being "beautiful, bizarre, fascinating, daunting, mysterious, majestic, labyrinthine, and awe-inspiring".

a_bonobo
0 replies
14h29m

OP's article lists the Krebs cycle as an example, to me the Krebs Cycle is a prime example of how not to teach biology.

Most high schools and every biology course uses the cycle as a milestone of learning, but usually teaches it by pure rote learning, words that have no meaning. Oxaloacetate turns into citrate via the citrate synthase and Acetyl CoA (I had to look this up; of course I learned it three times by heart and forgot immediately after the exam). Most of my teachers taught it like this, a meaningless collection of words and steps that you have to rote learn.

Except for my microbiology professor! We spent a semester learning about the basics of biochemistry, why reactions have to happen the way they happen, until we all had a relatively clear logic. We learned the Krebs cycle at the end, as a special kind of application and use case of the inherent logic. We want to 'reactivate' NAD+ into NADH, so we need an H+. But look at our Malate! There's a nice H dangling there in the OH group. Hs are taken off by dehydrogenases because they de- the hydrogen, so surely our helper is called the malate dehydrogenase. And it is! What happens to an O that has it's H taken away? the most usual outcome is a double-binded O. Which is why our oxaloacetate looks the way it does. If you know what malate looks like you know what oxaloacetate looks like. (And so on).

Of course you can't explain the entire cycle and its terms this way, as names like malate are there for historic reasons, but it gets you far closer to the inherent beauty of the thing. It's just a pity it's usually taught by rote.

freetime2
19 replies
21h38m

I loved biology in high school. I had one of the most boring teachers ever, and literally slept through class half the time, but then I would go home and read the text book for homework assignments and I found it totally fascinating. It was kind of running gag that the teacher could wake me up and ask me a question at any time and I always knew the answer, to the amusement of the other students. But my secret was just that I found it interesting and easy to absorb.

I don’t really like the idea of blaming others for one’s lack of curiosity about a subject. There are a lot of factors that determine how receptive we are to learning something - current interests, life experience, how developed our brains are, etc - beyond just the way it is taught. I have a much deeper appreciation for geology now than I did in school, for example, and I’m fairly certain that I’m the one who changed, not the way plate tectonics are taught.

AlotOfReading
6 replies
21h9m

Even if you pin the "blame" directly on teachers, they have a difficult situation. They need to get 3-5 classes of 20-40 mostly obnoxious kids to learn a broad array of material prescribed by other people. They have to do this while also correcting behavioral issues and dealing with parents or admins.

They're mostly not domain experts knowledgeable enough to give individualized deep dives to each of their students, but even if they were it would make their already-difficult task impossible. It's a wonder that any sort of individualized instruction manages to exist at all.

lannisterstark
4 replies
19h48m

Even if you pin the "blame" directly on teachers, they have a difficult situation

In many countries, teaching is a government position that is pretty impossible to get fired from. Unfortunately, just like in any profession, there are those in teaching who find it that they dislike it but still trudge along because nice benefits (not talking about US), much to the detriment of their students.

We talk about 'passion' a lot in a number of fields, but imho teaching is the only profession where you _NEED_ it.

Arainach
1 replies
16h3m

Bad management kills passion instantaneously. The best teacher, faced with administration which will constantly kowtow to parents and refuse to discipline bad students, will lose their passion rapidly.

giantg2
0 replies
15h18m

I had a friend who left teaching because of this sort of thing. They had a terrible experience as a student teacher and decided to work a job that paid less money.

The policies didn't just crush the teachers. Many of the students didn't care at all. There were behavioral problems, of course. One major issue he saw was that the school just pushed kids through the grades. There was a policy of an automatic minimum grade of 50% if the kid just put their name on the test... and they still at least one kid who would refuse to put their name on the paper!

Another friend of mine also went into teaching, but they refuse to work for public schools because of the bureaucracy, even though that sometimes means taking a paycut.

tracerbulletx
0 replies
15h53m

Even in districts where there is a union issue with firing, you could not easily find good replacements anyways. The pool of passionate teachers willing to take these roles is a small percentage of the total jobs, and they tend to self select into good higher paying districts with better behaved students.

giantg2
0 replies
15h25m

"there are those in teaching who find it that they dislike it but still trudge along because nice benefits (not talking about US), much to the detriment of their students."

This definitely happens in the US too. There have been documentaries made which include things like teachers just reading the news or a book whole letting the class do whatever it wants. Then the lawsuits and fight over tenure when the administration tried to fire them. Maybe the pay and benefits aren't great in many areas, but they're better than nothing, especially considering if you can do other things during work hours.

8bitsrule
0 replies
14h41m

When I was studying educational research, it seemed that most sources agreed that - apart from individualized tutoring - decreasing class size was one key to better learning. IIRC, the magic 'threshold) was 12. (Mob vs. seminar?)

Of course, teacher's real engagement with their subject and students, and teaching experiences (if they're in tune with what works, and also trying new methods) are important. As is whether their districts encourage (and can afford) innovation (in learning materials and media for example).

Regardless, teachers have to begin at the level of their average student (TBD); if the spread is too wide, some will be bored, some challenged. All of this is a lot to ask, moreso for teachers with outside lives to live and grow themselves also.

dangets
3 replies
20h34m

I would say the reverse is true though - great teachers are able to spark interest on a subject that students may otherwise not care about. But I agree that that expectation shouldn't be the baseline.

freetime2
1 replies
20h11m

I agree, and I may have downplayed the importance a pedagogy a bit too much. I’ve experienced first hand, and also see with my kids, the profound difference that a great teacher or coach can have on the pupils.

But a great teacher is not necessary to find a topic interesting, nor sufficient to spark interest in everyone who lacks interest.

mandibeet
0 replies
20h6m

Agree, they are not the sole determinant but still

Nevermark
0 replies
20h20m

Except making a subject interesting, at least for K-12, should be a baseline, no? (With success in early years making it easier to maintain high interest in later years.)

The most important thing you can teach about anything is an interest in it - otherwise what is retention going to be?

Or to turn it around, introducing subject after subject that students find boring, confusing, stressful or frustrating is a fantastic way to ensure they avoid anything to do with the fields, knowledge and skills we deem most important for a well prepared life.

I do agree that this isn’t a baseline to apply to each teacher in isolation, without the rest of the ecosystem supporting them. Textbooks, other materials and class aids, all supporting the emotional highs of learning, not just prioritizing a material to be covered on a test, etc.

At the university level, professors should be able to expect an opt-in self-selected and self-motivated level of interest for subjects.

Especially if grade school has prepared highly curious excited to learn students. As apposed to subject avoidance or apathy.

dkarl
1 replies
16h42m

I don’t really like the idea of blaming others for one’s lack of curiosity about a subject. There are a lot of factors that determine how receptive we are to learning something - current interests, life experience, how developed our brains are, etc

I've met former classmates who got interested in a subject later in life and literally would not believe that the subject had been taught to us in an interesting way in high school. They insisted "I would have loved the subject if they had taught us topic X" or "I would have loved the subject if they had taught us from angle Y" when that is exactly the way our high school teacher taught us. I think when we think back to age 15 we have a hard time remembering how different we were, and we remember things in a way that makes our emotions at the time make sense through our current way of experiencing things.

kuhewa
0 replies
9h58m

They insisted "I would have loved the subject if they had taught us topic X"

Just yesterday was a front page top comment along these lines, that teaching endosymbiotic origin of mitochondria and chloroplasts would have made all the difference in grade school biology. But really it would be worth about 30-90 seconds of content in the lesson that day and gone barely noticed and probably not remembered.

posix86
0 replies
11h5m

Textbooks are generally way more carefully made in terms of their presentation, the order of information, their examples. At least in uni, classes that follow a textbook where much nicer to get into for me personally. Why listen to an unmotivated professor reading his notes that he made in 3h for a one time audience of 300 when I could read a textbook that was made in the span of multiple years for an audience of hundreds of thousands?

maxglute
0 replies
9h39m

not the way plate tectonics are taught

There's more ways of learning now. Things I found interesting but taught fairly dryly, with even drier textbooks for self learning, I can now engage properly by watchign lectures/ listening at 2x speed. Find communities that meme about plate tectonics that makes me want to explore further etc.

kevbin
0 replies
17h5m

I don’t really like the idea of blaming others for one’s lack of curiosity about a subject… I’m the one who changed, not the way plate tectonics are taught.

100% agree.

The author seems to be arguing that it’s someone else’s duty to point out what’s interesting. I suppose a essayist or columnist needs to believe something along those lines.

dj_mc_merlin
0 replies
19h21m

High school biology is easy to memorize. Try doing that with undergrad level biology. Therein lies the problem.

dbrueck
0 replies
14h37m

A guide who loves the subject matter can make an incredible difference - I had a physics teacher who had a contagious love for it, and those who were naturally curious about the subject learned a lot while even the reluctant students couldn't help but be sucked in to his demonstrations and experiments.

I was fascinated by biology right up until I took 2 high school classes on it, and then it took years for me to recover. It had nothing to do with a lack of curiosity. In my classes, at least, the focus was on memorization of names of things. No time for wonder and amazement, what's important is that you can write labels on that diagram of endoplasmic reticulum! :)

I didn't take the article so much as the blame game but more saying that the subject of biology generally could be taught in a much, much better way. That certainly rings true for me and, from your comments, seems to ring true for you as well: you loved the subject despite how poorly it was presented to you.

cam_l
0 replies
15h33m

The thing that got me interested in biology and geology later in life was finding out / realising that there is a continuum between them and also with chemistry and physics (both of which I loved at school).

I don't fully understand why they are separated and taught as separate things, I wonder what the rationale is, apart from expediency.

thorum
12 replies
21h40m

I agree wholeheartedly with this:

In biology class, biology wasn’t presented as a quest for the secrets of life. The textbooks wrung out the questing. We were nowhere acquainted with real biologists, the real questions they had, the real experiments they did to answer them. We were just given their conclusions.

So - not just for biology - what are some good books or other learning resources that encourage questing, curiosity and wonder?

The first one that comes to mind is Feynman’s Lectures.

ampdepolymerase
4 replies
21h33m

Most of the pop sci books are useless for practical use cases, and similarly the Feynman lectures self select for the physics/mathematically inclined.

Biology is a leaky abstraction, it's very hard to do anything with rigor without having a strong foundation in the fundamentals. You see the same discussion on hacker news when it comes to music, people are more interested in mapping programming concepts to music notation and complaining about western music presentation than the music itself. For biology, you need need to have a firm understanding of the central dogma and biochemistry if you want to do anything beyond surface level empirical trial and error. Most people, especially the "hacker types", only have a vague understanding of the former i.e. DNA translation and transcription and that's about the limit. You absolutely have to gain an intuition for biochemistry if you want to do things with rigor, otherwise you will just be the biotech equivalent of a bootcamp web developer, fit for washing test tubes and not much else.

MajimasEyepatch
3 replies
21h19m

Absolutely right. These basic concepts like the central dogma aren't especially hard to learn, but it's important to really understand them deeply if you want anything to make sense.

Among textbooks, Molecular Biology of the Gene by James Watson et al. is a good starting point to understand the central dogma: DNA -> RNA -> Protein. Likewise Molecular Biology of the Cell by Alberts et al. for cell biology.

An Introduction to Systems Biology by Uri Alon is good for the more mathematically inclined once you're ready to get more advanced, though you should really have a solid grasp on the fundamentals of molecular and cellular biology first.

None of this is for the faint of heart, but it's not especially difficult either. It's unfortunate that it's hard to get hands-on experience with biology once you've graduated from college, which helps a lot to connect the dots, but there are still plenty of great resources out there.

kaiwen1
1 replies
20h38m

Molecular Biology of the Cell is one of my all-time favorite books. Read it 15 years ago, rereading it now in the 7th (newest) edition. If someone has read the books you've listed, done the exercise and has a comprehensive understanding of the material, but no biology degree, only a passion for learning about cell biology, are there job options to keep feeding that passion?

ampdepolymerase
0 replies
20h18m

Work/volunteer as a minimum wage software developer lab rat (or whatever your day job speciality is). There are plenty of labs that are in need of free labor when it comes to software/engineering support in general, just ask around.

BlueTemplar
0 replies
11h24m

the central dogma: DNA -> RNA -> Protein

Funny thing : having never seen the term "central dogma" before, I looked it up, and Wikipedia says that this one (directly calling out your reference) is an incorrect version, in fact has been proven wrong in the last decades, while the original Central Dogma holds.

Even funnier thing : I kind of lied : I saw that term for the first time two weeks ago... when watching Neon Genesis Evangelion. Where it's a location. But then I guess it also throws around terms like "apoptosis" (which I did knew and which made me raise an eyebrow) as sciencey sounding words (still somewhat appropriate to the context in a metaphorical way), so of course it couldn't resist "Central Dogma" as a play on words between biology, location, and (anti-) "Orientalization" of Christianity !

willturman
1 replies
20h53m

Desert Solitaire - Edward Abbey

A Brief History of Nearly Everything - Bill Bryson

Entangled Life - Merlin Sheldrake

The Hidden Life of Trees - Peter Wohlleben

veddox
0 replies
9h54m

Just to add as a caveat that Wohlleben's books are regarded quite critically by most forest ecologists I know. The general consensus seems to be that he picks up on real phenomena and is a vivid science communicator, but has a tendency to greatly exaggerate what we know.

veddox
0 replies
9h57m

Aldo Leopold, "Sand County Almanac".

In German: Josef Reichholf, "Mein Leben für die Natur".

signal_space
0 replies
18h18m

check out uri alon’s introduction to systems biology

sampo
0 replies
21h21m

So - not just for biology - what are some good books or other learning resources that encourage questing, curiosity and wonder?

The first one that comes to mind is Feynman’s Lectures.

The early books by Richard Dawkins. Also later books when he writes about biology and not about religion.

robocat
0 replies
20h0m

For biology I loved most of Stephen Jay Gould's books. Ignore the detractors: the books are interesting!

ReleaseCandidat
0 replies
21h35m

what are some good books or other learning resources that encourage questing, curiosity and wonder

Children. Best before they enter a school (or anything resembling something similar).

plaidfuji
10 replies
17h25m

For a computer scientist, a biologist’s methods can seem insane; the trouble comes from the fact that cells are too small, too numerous, too complex to analyze the way a programmer would, say in a step-by-step debugger.

I think this is probably the part about biology that people outside of biology appreciate the least. We know a lot about how cells and proteins work now. But despite this fact, it is still extremely difficult to understand exactly what is happening within a given cell in situ. Many measurement methods are likely to destroy or alter the thing you’re trying to measure… think Heisenberg’s uncertainty principle - the act of measuring the thing changes its state. Everything is sensitive to temperature, shear, ionic strength, pH, etc… and of course most methods rely on these levers to gain resolution and signal. So you have to have a clear idea of what you think is happening to even select a measurement technique that won’t ruin it. This is part of why, while we know a lot of the fundamentals, it is still hard to engineer functionality in specific environments .. engineering requires a lot of measurement and feedback.

I think that also offers insight into why software can be engineered so quickly. It’s a discipline where you can (relatively) easily place a probe wherever you want and understand exactly what’s happening in a (sometimes) deterministic manner. Everyone else is taking fuzzy shots in the dark compared to software. Imagine replicates being a thing you have to think about when debugging a program. Like in software, running your code again with no changes after it just failed is insanity. In every other engineering discipline, you sometimes have entire meetings to decide how many times to retry something that just failed.

JR1427
2 replies
9h18m

For a computer scientist, a biologist’s methods can seem insane;

I actually use biological methods all the time, now that I'm a dev. For instance in Biology, gene knock-out experiments are common, where you damage or delete a gene, and see what breaks. You then know that this gene is important for a given thing.

This is the equivalent to the debugging approach of "if I comment out this code, what happens?"

pfdietz
0 replies
5h39m

Mutation testing literally has a biological term in its name.

NL807
0 replies
7h5m

Not to mention, you can also do things like fuzzing.

jbm
1 replies
16h42m

This is exactly why I switched to computer science after finishing my biology BSc.

I don't get nightmares about analytic chemistry anymore, but the level of self-loathing you get from doing labs that never work out for reasons that defy understanding make the annoyance of debugging code seem quaint almost.

(I should really say "it used to", but now that I can run an LLM call locally and get a completely different response than the deployed version of a piece of software, with all other factors seemingly being equal...)

adonovan
0 replies
15h45m

I too switched from biochem to CS: it was such a relief to work in a field where I felt that, as in math, you can get by remembering axioms and rules and derive the rest, without all the arcana of biology. (My mentor in biology bought me a copy of Barrow & Tipler as a parting gift, as if to say, CS and biology are not so different.) Today I’m not sure I still feel that way. Programming is more an empirical than logical discipline that ever before, as programs are too complex to be objects of pure reason; and the layers of stuff one needs to know keep growing in both directions, from SIMD to OAuth.

I’m so glad to come across this writer though. I was going to send them a note to tell them they have a real talent, until I noticed the long list of New Yorker and Atlantic publications, and thought: they already know. :)

cameronh90
1 replies
15h41m

The fundamental challenge of most engineering disciplines is attempting to create a model that represents a useful subset of reality but can be easily reasoned about and is, in some sense, reliable or reproducible. Perhaps what makes computer science unique is how unusually successful it has been in wrangling physics into a machine that appears to execute the laws of mathematics. Physics does rear its head from time to time (e.g. rowhammer and "single-event upsets"), but it is truly impressive how little we have to consider the physical nature of the machine nowadays.

However, other engineering disciplines do also try to build similar abstractions with varying levels of success. We've managed to build simple books of electrical standards that can be used by electricians around the world to build and reason about power systems without having to understand the weird quantum mind of an electron. I suspect we'll get there with biology too, we're just a century too early.

kurthr
0 replies
15h11m

Computer engineering is literally designed to allow the most simple reliable substrate for the most complex possible abstractions to be built upon. It's bizarre (but common?) for computer science practitioners to be strangely unaware of how artificial the tools they use are. Then expecting the rest of the world to be as "simple" as their environment.

   logic: analog>digital
   gates: multi-level>binary
   timing: ripple>global clock
   architecture: logic>ISA/CPU/GPU
   memory: register/cache/disk>monolithic VM
   language: binary ASM>Compile/Interpreted
   memory/device: management interrupt loop>Kernel/OS
   Libraries, Frameworks, Virtualization
It goes on and on.

Semiconductor processing on the other hand is physics. Success is discovered rather than primarily designed. There are development tools, but things like the "pixie dust" used to avoid the superparamagnetic limit in spinning media were not understood for years after they were commercially shipped in hard drives. Biology/Pharma is much more complex/hit-miss and the biotech industry treats most employees quite badly.

sbierwagen
0 replies
13h5m

the trouble comes from the fact that cells are too small, too numerous, too complex to analyze the way a programmer would, say in a step-by-step debugger.

It's like analyzing a Swiss watch if the back was welded on. You could send it though a shredder and analyze the fragments and work backwards to determine the size of the gears. But it's impossible to shred just one watch-- you have to shred a hundred thousand at a time, which are inevitably a complex mix of different watch models each with different minute lengths and hour durations.

Something I have felt is undertaught in introductory biology is how unknown human cells still are! No textbooks wants to list off a thousand proteins with "function unknown" next to them, after all. But to surprisingly large extent it's an undiscovered country. Just in the last few years we're discovering entire new species of RNA! https://www.science.org/content/blog-post/enter-glycornas

isolli
0 replies
6h14m

Good point. It reminds me of an observation made by Paul Sutter in his podcast [0]. Paraphrasing, there so many layers of emergent phenomena, most of whom we will probably never figure out:

- From quantum fields to atoms

- From atoms to chemistry

- From chemistry to biochemistry

- From biochemistry to cellular life

- From cellular life to multicellular life

- From multicellular life to consciousness

- From individual consciousness to social phenomena

[0] https://podcasts.apple.com/en/podcast/ask-a-spaceman/id95882...

bobbylarrybobby
0 replies
15h12m

Minor nit: the observer effect is distinct from the uncertainty principle, which says that two quantities like position and momentum (“conjugate variables”) cannot simultaneously be known to arbitrary certainty, which is to say, their wavefunctions cannot be simultaneously localized to arbitrarily small regions (of their respective spaces). This applies to any two functions that are Fourier transforms of each other, which position and momentum are (my terminology is sloppy here, but close enough to be useful), and has nothing to do with the change to a wavefunction that occurs by measuring it.

rrr_oh_man
9 replies
21h39m

This resonated a lot:

> Enormous subjects are best approached in thin, deep slices. I discovered this when first learning how to program. The textbooks never worked; it all only started to click when I started to do little projects for myself. The project wasn’t just motivation but an organizing principle, a magnet to arrange the random iron filings I picked up along the way. I’d care to learn about some abstract concept, like “memoization,” because I needed it to solve my problem; and these concepts would lose their abstractness in the light of my example.

Terr_
5 replies
19h11m

This also applies to less-cerebral tasks. For example, I didn't learn to touch-type due to a school class with edutainment software, but because after one summer of arguing with people over dial-up, I had learned it just to get the words out faster.

agileAlligator
3 replies
12h24m

Exactly how I learned to touch type; only it was Discord not IRC. The more things change, the more they remain the same.

namaria
2 replies
7h6m

Same here. I learned touch typing to furiously debate online as well =)

MSN messenger in my case haha

Izkata
1 replies
2h38m

I guess a less usual one, compared to the other comments: For me it was StarCraft multiplayer, had to type fast so I could get back to controlling my units.

Because I was rapidly going back and forth between the keyboard and mouse, it resulted in an unusual style where I use the outline of the keyboard for hand placement, and attempting to use the home row slows me down significantly.

Esus
0 replies
2h16m

Surprised no one has mentioned Runescape. Touch typing felt like the only option for GE spamming lol.

xcdzvyn
0 replies
9h50m

Necessity is the mother of invention :)

Esus
1 replies
2h17m

Does anyone know if there's a mental model or term to describe this? Would like to broadly read about more examples of this.

AnimalMuppet
0 replies
2h12m

Maybe "just in time learning"? Learn the next thing you need in order to be able do whatever you're trying to do.

The danger is that you won't know enough of the landscape in order to know what piece you need to learn to unblock what you're trying to do...

willturman
0 replies
21h0m

It’s a wonderful experience when hazy abstractions of complexity click into clarity. I’m not sure I’ve ever found that without tangible motivation and immersion in a problem space, although excellent writings can bring one to the doorstep.

npunt
7 replies
19h43m

Nobody's talking about the author's point at the end of the article, that we need better tools to reason about biology, and that the biology as a subject has a particular gap between reality and content that perhaps other subjects do not.

I couldn't agree more. Right now we're sipping the natural world's most complex ideas through the straws of simple language and static diagrams, and the constraints of all of these mediums (including school itself) in aggregate naturally lean toward making biology a rote memorization subject. Reasoning about biology in the way that it appears in nature is, in these mediums, going against the grain. It happens, but it's not the default. Your story about having a good biology teacher is this exception, not the default.

Complex things requires easy to use systems that reflect that complexity. That's the subject here - how do we build these methods of communication and understanding?

piecerough
2 replies
19h40m

Isn't this what we're all betting massive Transformer architectures are going to give us? Tools to explore and handle complex concepts. Reasoning may still be left to us, though.

npunt
0 replies
19h35m

Absolutely! Super exciting! But how precisely will it work?

Right now I don't know of an AI tool that can make a halfway decent biology diagram, let alone a complex 3d animation of a biological process you can talk to and ask questions of. The article was a call to action for this type of tooling.

I'd love to see this thread move from 'my experience in school was good/bad' to 'what if we made something that did X' or 'have you seen Y' :)

Balgair
1 replies
12h49m

Hey, neuroscientist here.

It's going to be a few hundred years before we get to that point, if we ever get there.

Bio is just really complicated, there may never be anything like a 'easy to use system.' We're still on the beach of it's ocean, counting the colors of stones.

For instance, in developmental bio (going from one cell to a functioning infant) we have three theories of how a cell determines what it should develop into: 1) The English model: The daughter cells get told what to be by the mother cells 2) The American model: the daughter cells take a look around themselves and determine what to be by taking a poll of the other nearby cells 3) The Las Vegas model: it's all random with lots of apoptosis and going broke.

They very fact that we think these models are right is very concerning to the field. We know deep down that none of this can be correct, but have not been able to disprove it all that well. To be clear here: dev biologists are nearly certain that their theories are crap, based nearly entirely on gut feelings. That's how gun-shy biologists are with any whiff of a 'grand theory'. That's how complicated things are.

It's not a given that bio can really ever be reduced back down to something understandable and simultaneously reflective of the 'real' state of things. That's not something nature is obliged to provide us.

zkmon
0 replies
8h9m

Even more fundamental question is - why does a cell divide? All literature that I came across tells me "how" a cell division happens, but not "why"? What's the cause? What's the motive? For example, in Physics, the cause or motivation is reaching an equlibrium or minimality of energy transferred, entropy etc. For cell division - what's the nature's goal? Having more cells? Why?

breck
0 replies
18h2m

Complex things requires easy to use systems that reflect that complexity...how do we build these methods of communication and understanding?

We've had the wetware for understanding complex systems for thousands of years. We added symbolics for communicating complex things later.

Nowadays, many people weak in symbolics are excellent in understanding, and many people expert in symbolics are novice in understanding.

I am not sure whether we are missing a symbolic form that is closer aligned to understanding, or whether we've simply overvalued symbolics at the expense of understanding.

bglazer
0 replies
16h21m

I have a hot take that biology is just too complex and complicated for humans to truly understand.

We have the cognitive ability to reason about the relationships between about 150 humans. So, if thats a plausible upper limit for how many genes we can hold in our head too, then we’re toast. Each cell has thousands of distinct proteins, and many more small molecules. When we knock out one gene, we regularly see hundreds change in response. We just can’t hold that large of a system in our head. Parts of it, maybe, but genes are so interconnected that it’s very hard to draw a sensible boundary between distinct “parts”. Also biology behaves in really unintuitive ways. Feedback loops, randomness, long tailed distributions. These are very important concepts for biological systems. Humans are also notoriously bad at thinking about all of them.

It’s just too big and too weird to try to think about a single cell. Forget tissues or organs.

So, I think computational modeling will be really important to teach to students early. We have to rely on computer models because its too complex for our brains.

mcmoor
4 replies
16h36m

I notice that every single thing the article talks about is cellular or molecular biology, which I did immediately like while in high school for reasons mentioned. But the reason why I don't actually like biology is the entire other parts of it, namely taxonomy and environmental biology. I just couldn't care about it. I don't want to know how to differentiate between ants based on how many antennas they have, or what this biome actually is based on percentage of pine trees there are. And I suspect lots of the time, when people talked about biology they actually talked about this because this is what's actually taught in elementary and middle school where impressions are formed. And this is what Feynmann refers to as "stamp collecting".

veddox
0 replies
10h0m

You're doing to ecology exactly what the author complains teachers are doing to molecular biology.

Learning about molecular biology often begins with memorising what the cell is made of. I understand that many students find this dry and tedious. But it is in a way necessary, because only once you have this foundational knowledge can you go on to begin to understand the amazing complexity of how it all actually works.

Ecology is similar. Yes, taxonomy can be a drag (certainly in high school, or even early college). But you need to learn something about what's out there before you can start to think about, and wonder at, how it works. Ecology is an amazing subject, as complex and intricate as anything in molecular biology. (In a way, it's even more cryptic than the latter, because most of the experiments can't be done in a lab.) The problem is that most people have no clue what's out there, and so they never see the beauty that surrounds them, or realise the wonderful web of life playing out all around them.

Come for a walk with me through the woods, and let me tell you something about how ants grow their own food, or go to war with a neighbouring tribe, or treat their wounded with antibiotics. Or let's take a look at a dead tree, and see how the fungus has softened the wood, how beetles have burrowed through it, how they in turn attract woodpeckers, whose holes are then re-used by owls.

Due respect to Feynman as a physicist, but he had no clue about ecology. We are not collecting stamps, we are collecting the stories they tell - stories you'll never hear if you don't look at a few stamps first...

melagonster
0 replies
16h20m

This is normal way how molecules biologists gibe ecologists.

The war between subdisciplines never end.

a_bonobo
0 replies
16h22m

Ed Yong recently published a beautiful article on the joy of birding: https://www.nytimes.com/2024/03/30/opinion/birding-spring-me...

To me, birding always seemed to be the worst kind of Feynman's stamp collecting. But there's so much more beauty and joy hidden in knowing what lives around you in detail; your connection with your surroundings will grow deep.

To quote: >So much more of the natural world feels close and accessible now. When I started birding, I remember thinking that I’d never see most of the species in my field guide. Sure, backyard birds like robins and western bluebirds would be easy, but not black skimmers or peregrine falcons or loggerhead shrikes. I had internalized the idea of nature as distant and remote — the province of nature documentaries and far-flung vacations. But in the past six months, I’ve seen soaring golden eagles, heard duetting great horned owls, watched dancing sandhill cranes and marveled at diving Pacific loons, all within an hour of my house. “I’ll never see that” has turned into “Where can I find that?”

fmy105
4 replies
19h40m

This article resonates with me deeply. Like the author, I found my high school and college biology classes to be a dry litany of jargon and diagrams, sucking the wonder out of the incredible machinery of life.

It wasn't until years later that I began to grasp the profound beauty of biology through books like "The Eighth Day of Creation" mentioned in the article. The great revelation for me was that at its core, biology is a physical, engineering discipline - it's all about how 3D shapes and surfaces interact and fit together to produce structure and function, from protein complexes up to tissues and organs.

I wish more biology education focused on cultivating that sense of awe at the nanoscale world of the cell. Imagine if introductory classes posed biology as the greatest reverse-engineering project in the universe - here is this self-replicating machine of staggering complexity, your task is to figure out how it works! Let students discover for themselves the logic and elegance of core concepts like the Central Dogma.

The other key point is that evolution needs to be the central organizing framework, not an afterthought. You simply cannot make sense of biology without viewing it through the lens of evolutionary processes shaping structure and function over deep time. When taught this way, even rote memorization takes on new meaning.

We are living through a golden age of biological discovery, from the frontiers of neuroscience to the dizzying possibilities of synthetic biology. I hope we can inspire future generations to share in that excitement by presenting biology as it truly is - the grandest puzzle and most awesome technology on Earth. Let's bring the wonder back into how we teach the science of life.

bokoharambe
1 replies
18h6m

Your post really demonstrates how different people can have very different experiences of the same field. I love biology too, yet I care very little about chemicals or chemistry, and I wish there was more of a track for studying biology while abstracting away from the biological particulars. An approach to biology focused on the large scale- ecology, biospherics, and life exists as a geophysical phenomenon, would be really nice. That's the sort of thing that I care about, and you really don't need to reference the nanoscale in detail for considering it.

I think we can all agree though that the unstructured memorization approach benefits 0 students.

bglazer
0 replies
16h49m

You might enjoy this course form Yale. It’s called Ecology, Evolution, and Behavior. I listened to it as a podcast several years ago. It was my first introduction to “real”, not high school, biology, and it blew my mind. The material is presented at exactly the level you describe, mostly abstracted to general principles that guide all of life, but the professor also presents really fascinating examples of how each principle is instantiated in nature. I found it to be very approachable too, as a computer scientist.

It was a big part of my inspiration to go to grad school to study biology. So be careful haha. Don’t end up a grad student like me.

One final note is that biology is exceptionally weird in that the chemistry and the big principles like evolution are inseparable in reality. You can certainly study them separately but there are a few things that just won’t make sense without understanding some of the molecular details.

https://youtube.com/playlist?list=PL6299F3195349CCDA&si=GQId...

quantrox
0 replies
11h37m

I found my high school and college biology classes to be a dry litany of jargon and diagrams, sucking the wonder out of the incredible machinery of life.

Indeed, same here. As of myself I always liked the biology but the way it was teached was always far from what could be considered as good.

For example, I remember classes about proteins. There were some mentions about protein structures, from aminoacid sequence to 3-d shape. But it was never explained what the proteins are actually doing and why they need to have different shapes. Why do we need so much of them? I remember that it was very profound experience when I discovered how complex is the molecular machinery and I started to look on the biochemistry from completely different perspective

QuantumG
0 replies
18h34m

The second half of the article is certainly preferable to the whining at the beginning.

fabian2k
4 replies
21h46m

My experience with high school biology was similar, though that might have been that particular teacher. He was close to retirement and while he could have identified most plants in the region, he could not answer most of my questions about biochemistry.

I found that the first semester of biochemistry at university alone changed my understanding of biology. The quality and depth of the education was so much higher than what I had in school before. A large part is of course that it is so much more focused, you could not go to that depth in a general purpose school education.

It does go again in a different direction later. Once you learned the general principles you might have to learn all the inconsistent details that are present in the actual biological systems. And the immune system is certainly one of the worst offenders here. There are a lot of really fascinating aspects about it, especially how it adapts and learns. But you quickly get to a points where you're just overwhelmed by the incredibly amount of different parts that play a role in it.

grogenaut
2 replies
20h50m

when were you in highschool? I took honors bio back in 93 in highschool and it was all memorization of aniimal and plants parts. I'm taking bio 180 at UW now (20 years after graduating college) and it's all about genetics and statistics. They're almost different subjects. One is closer to farming and exploring and the latter is more science and the unseen. I could totally see an end of career hs teacher staying with the older style.

Also I bet that dude knew where all of the morels grew.

fabian2k
1 replies
20h43m

A bit later than you, and not in the US. But as my teacher was born around World War 2 (estimated from their retirement date) I don't think it is unexpected that they had a very different view. Biology has fundamentally changed in that timeframe.

grogenaut
0 replies
20h30m

My teacher back then was in ww2. He actually was one of the army kids in the closer bunkers who were somewhat unwitting test subjects. He had a recording of him being interviewed after one of the first tests. He said he was 18 at the time. He said "I think this might just change the world" or something like it. I couldn't find the interview with a quick google. His last name was stocker. He was actually a great teacher in basic science the year before which is why I took honors bio but I zoned out memorizing all of the names of parts of sponges. The kids in regular bio were dissecting pig fetuses.

The man had a photo of an orangutan on his desk facing class with the name plate "moker joe". "An orangutan could get about 50% on this test", he'd say and walk around saying to the kids he knew weren't studying "Moker Joe's gonna get you Craig". Some of the smart kids pointed out to him that Moker would probbably get way less than 50% at random probability. "yeah but the kids moker's gonna get don't know that".

Anyway it's definitely more interesting this time around and only taking one class at a time.

ReleaseCandidat
0 replies
21h26m

My experience with high school biology was similar, though that might have been that particular teacher. He was close to retirement and while he could have identified most plants in the region, he could not answer most of my questions about biochemistry.

That's a totally different problem. Nobody can expect a teacher (or scientist, or ...) to be equally interested in all subfields. Of course, they should know "what is needed" - whatever that means, for example to teach the part of biochemistry that is in the curriculum. I, as a mathematician, for example don't care much about statistics or number theory. As somebody generally interested in biology I don't care about biochemistry. So, as long as he didn't just say "fuck off", you can't blame your teacher for liking something else than you did.

pfdietz
3 replies
22h4m

There is no date on that?

(He says it was from his blog, but it's not actually in the blog.)

AlotOfReading
1 replies
22h1m

The page was first archived in November 2020, so probably thereabouts.

jeffhwang
0 replies
21h58m

From the article, "A few months ago, I started a magazine assignment to answer some questions about SARS-CoV-2 and the immune system. I encountered paragraphs like this"... and the author links to this this [1] New Yorker article about COVID that was published November 2020. So from context clues, was probably published in late 2020.

[1] https://www.newyorker.com/magazine/2020/11/09/how-the-corona...

Terr_
3 replies
19h17m

Imagine a flashy spaceship lands in your backyard. The door opens and you are invited to investigate everything to see what you can learn. The technology is clearly millions of years beyond what we can make.

This is biology. –Bert Hubert, “Our Amazing Immune System”

I like to refer to it as nanotechnology beyond human comprehension, discovered on a planet that experienced a "grey goo" apocalypse. Every possible pore of its surface is now infested rogue units, in a constant arms-race of development. Some have even been yoked into titanic moving megastructures and inscrutable hive-minds.

Terr_
1 replies
17h51m

Tangentially related: We like to imagine cyborg metal bodies, but we don't always appreciate all the features of our standard nanotech. From an old post:

________

When it comes to the bio-engineering of the human limbs, just remember that you're sacrificing raw force/speed for a system with a great deal of other trade-offs which would be difficult for modern science to replicate.

1. Supports a very large number of individual movements and articulations

2. Meets certain weight-restrictions (overall system must be near-buoyant in water)

3. Supports a wide variety of automatic self-repair techniques, many of which can occur without ceasing operation

4. Is entirely produced and usually maintained by unskilled (unconscious?) labor from common raw materials

5. Contains a comprehensive suite of sensors

6. Not too brittle, flexes to store and release mechanical energy from certain impacts

7. Selectively reinforces itself when strain is detected

8. Has areas for the storage of long-term energy reserves, which double as an impact cushion

9. Houses small fabricators to replenish some of its own operating fluids

10. Subsystems for thermal management (evaporative cooling, automatic micro-activation)

sweetjuly
0 replies
15h31m

This is one of my favorite sci-fi concepts.

There's only so far your high tech nano-particle swarm can spread before resources become a serious limiting factor. If you're limiting yourself just to earth, certain resources that a swarm might need to reproduce will be scarce/energy intensive to extract and utilize (mining rare earths, fabricating highly advanced semiconductors, etc.). It's extraordinarily easy, however, to produce billions of cells nearly anywhere on earth because the cells that we have are especially adapted for ease of reproduction in these exact conditions.

Lucent
0 replies
17h28m

This is how I now see biology, and more so with each reframing. Cells being squishy, floppy bags no longer counts as a point against them being "tech" or "robotic." That's deliberate engineering—a complex scaffold of nanotech ladders that continuously reform to emulate "squish" as a feature.

paulgb
1 replies
19h38m

Thank, Dan. Some further context: this was posted in another thread yesterday: https://news.ycombinator.com/item?id=40102956. I liked it so much I yoinked it and submitted to main.

wy35
0 replies
9h49m

Wow, downvotes were harsh here.

FWIW I don’t think it’s a bad thing to repost articles that were last posted years ago. I didn’t see this article when it was posted in 2020 and 2022, and I probably wouldn’t have seen it ever if you didn’t repost it now.

Jerrrry
2 replies
21h19m

Biology is unique; no other classical study, in modern practice, (can) contain both the sheer magnitude of complexity and the propensity to sweep away that same complexity with just a mere (if only temporary) classification.

This may be a result of academic laziness - the question begs, especially when the answer is known. But showing your work is tedious in some fields, and impossible in others. The questions posed in biology must be formulated to be answerable a-priori with evidence that often appears to be biased towards confirmation outside of the domains of specialized experts.

It's hard to inspire wonder in the juxtapositional environment where any discovery will, at minimum, produce a magnitude more questions - all to be relegated to labels until another wave of motivation and technological processes facilitate another plateau of progress to be confronted.

Biology is hard. It's like reverse engineering, from scratch, the watch you found on the beach; 50 years and 50 miles away from the watch factory.

wrs
1 replies
20h48m

It’s much, much harder than that! The watch was at least designed by a human, with parts that have at most a few simultaneous functions. All the parts are big enough to see, and made of metal so constant shape-shifting isn’t part of their functionality. It was mostly designed to be understandable. Biology is just a giant soup of whatever works. Any organizing principles are accidental or only exist in the eye of the beholder.

Finding some temporary unifying mechanism or principle to organize understanding with is the only way to make progress, but the history of biology is packed with ideas that eventually hardened into dogma and blocked progress until somebody managed to blow them up.

Jerrrry
0 replies
20h22m

Biology is just a giant soup of whatever works. Any organizing principles are accidental or only exist in the eye of the beholder.

Evolution is the difficult-to-understand answer to this; we tend to anthropomorphically and erroneously assign intent and purpose in a chicken/egg and begging-the-question way.

Life continues until it doesn't; to assign any more gravitas to our collection of localized complexity is the same awe that a plebeian holds when presented with a meatball-and-spaghetti-on-a-wall painting of modern art; ignorant to them that it was all that remained after a rather particularly sticky food fight.

veddox
1 replies
9h42m

Speaking as a biologist, it saddens me every time I hear somebody say that they dropped biology as soon as they could in high school, because they inevitably do so just before it starts to get interesting.

The problem is that biology is a subject where you need a lot of fundamental knowledge before you can start to understand how things actually work - simply because the systems involved are so complex and have so many interacting parts. You need to learn an awful lot of facts before you can start putting the puzzle pieces together to see the big picture. But once you do, the view is amazing!

As an aside, I lament that the author equates "biology" with "molecular biology". He completely ignores the wonders of ecology - the beauty of biodiversity, the marvel of trophic cascades, the intricacies of ecosystem functioning. In fact, I think the challenges he sees for molecular biology are heightened for ecology: what you learn of it in high school is often even drier, you need even more background knowledge to be able to see the big picture, and research is even more challenging because experiments can seldom be done in a lab. Yet, once you've dug your way into it, you get to see systems at work that span the globe, that are as complex as anything that happens in a cell, just more vibrant and tangible and alive.

jeffreyrogers
0 replies
34m

I don't think you need that much context if you start with an organ system. For example, I got interested in biology by learning about how the kidneys work. You can give a pretty handwavy explanation to get someone oriented and then go into more and more detail (for example about the structure of the nephron, the hormones involved, how filtration works at a molecular level, etc.)

The other organ systems are similar. Once you know about the organ systems development and genetics are well motivated and easier to pick up. And from there you have a pretty good scaffold from which to fill in the rest of human biology.

texthompson
1 replies
16h10m

Someone probably told me that every cell in my body has the same DNA. But no one shook me by the shoulders, saying how crazy that was.

This is only mostly right. Every cell in your body has an astonishingly similar amount of DNA, but every cell division (and even steady state DNA repair) offers the opportunity for mutations. So your cells are all astonishingly similar, but there can be detectable differences.

One implication of this is that cells that are closer to each other in developmental history will have more similar DNA. One of my colleagues in graduate school used this to do phylogenetic lineaging, where he looked at markers in DNA from whole organisms to reason about which cells are closely related, and which cells have a more distant developmental ancestor.

Biology is super cool! I hope that everyone finds a little bit of it that they can enjoy. :)

j7ake
0 replies
16h7m

Also B cells and T cells undergo genomic rearrangements to get a diversity of receptors that can make specific targets.

streptomycin
1 replies
21h38m

When I took biochemistry as an undergrad, it was taught by a somewhat eccentric professor who instead taught it more like "History of Molecular Biology". And it was super interesting.

But all the premed students hated it lol

Besides that, every other bio course I ever took was just rote memorization (except ones taught in math/engineering departments). Bio 101 was maybe the hardest class I ever took because it was so damn boring to memorize all those random facts.

grogenaut
0 replies
20h47m

This is why I didn't take it when I got my undergrad. I was good at formulas and bad at memorization. I'm taking it now 20 years later after getting an EMT certification and realizing that yes I can do memorization. That said I'm taking intro bio right now and it's not that much memorization. End goal os ti take org to see how bad it is.

montebicyclelo
1 replies
20h32m

It does seem to be the norm for interesting things to be presented in a boring way, rather than the exception. I'd guess this is partly because it's difficult to explain concepts clearly in the first place, let alone make the explanation engaging...

Hypothesis: If writing educational material is like throwing a dart, you have a bigger target if you aim for just "clear" — if you aim for "clear ∩ engaging" you have less chance of being "clear".

    size(clear ∩ engaging) < size(clear) 
I think time pressure would come into play with this. If you have the time, you can hone in on the "clear ∩ engaging" zone; but if you are pressed for time you just aim for "clear" which you'll hit more quickly.

And if you're really pressed for time (and/or uncaring), you might aim for "passable" rather than "clear"; something that your colleagues would OK, but that isn't particularly great. This is a larger target than "clear".

    size(passable) > size(clear)

makeitdouble
0 replies
18h29m

A bigger issue would be that a course isn't presented to a small group of kids who need to be engaged ("shaken by the shoulder" as the author says), it's for the whole class, including:

- kids who're already engaged, though aren't studying on their own and need some bare explainations

- kids who don't want to be engaged and won't be anyway

- kids who could be engaged depending on some other factor that no other kid cares about

Teaching to a class of 30+ kids means you can't take any extreme bet on what will work as a teaching method, and going for the most energy efficient way is a good practice in general.

lannisterstark
1 replies
15h10m

As someone who is a few years into their CS career, I wish I knew where to 'restart' learning sciences (bio,chm,phy). I am quickly overwhelmed by the plethora of resources people throw at you when you ask that question (There's Khan Academy, there's OCW, there's actual textbooks, coursera, pop science etc)...

Anyone manage to at least start? If so, where? I mostly forgot my university level science courses.

ray__
0 replies
1h4m

One option would be to start from what you already know–there are many opportunities to apply CS to life/physical sciences problems. I like rosalind.info, you can start with code and then read independently to fill in any gaps in your knowledge that you come across.

keyshapegeo99
1 replies
20h35m

Beautifully written piece whose premise I disagree with.

At least in the UK (the States may be different), you are taught many of the concepts and underlying reasoning that the author bemoans not having learned.

At A-Level standard, you are taught the physical basis of epigenetic modification (what he describes as switching genes on or off - although that in itself is a too-binary simplification, it's more to do with up- and down-regulation of expression). You're also taught other fascinating processes such as alternative splicing - where a single gene can express many different proteins.

During my first year of undergrad at a so-so Russell Group university, the history of biology featured prominently in lectures - especially those on the evolution of genetics as a field. The inherent fuzziness of categories and concepts in biology was also made very clear. I distinctly remember a lecturer telling us (in response to a question about why we say bacteria don't have membrane-bound organelles, when the topic of the lecture - the magnetosome - was clearly an exception to this rule) that when we say something is 'always true' in biology, we mean it happens 80%+ of the time, and when we say something 'never happens' in biology, we really mean that it happens less than 20% of the time.

I do agree that there is sometimes a bit too much of an emphasis on rote learning the chemical minutiae at the expense of the broader, more important concepts (Krebs cycle, anyone?) - but I think this case is overblown by the author.

icambron
0 replies
20h22m

I took high school bio in the US, and mostly agree with both of these:

you are taught many of the concepts and underlying reasoning that the author bemoans not having learned

there is sometimes a bit too much of an emphasis on rote learning the chemical minutiae at the expense of the broader, more important concepts (Krebs cycle, anyone?)

But note that the author was almost certainly only talking about high school biology.

I think the situation is that in the US, an AP Biology (bio class for seniors in high school) teacher has to trade off teaching the concepts with teaching to the AP test all the seniors will take, and that test prep does involve stuff like memorizing the Krebs cycle so that you can forget right after the test. My teacher did a pretty good job of this balance and I got a lot out of it, but mileage may vary. Next, the kids will do well on the test and that will let them dodge their university's biology requirement. That class would have been much better. (I'm was in exactly this camp.)

pfdietz
0 replies
5h21m

Also: the modification of DNA in B Cells, for the formation of new antibodies. It's akin to generation of new inputs in fuzzing.

https://www.ncbi.nlm.nih.gov/books/NBK26860/

jll29
1 replies
21h34m

There isn't another book like "Gödel, Escher, Bach"; when I ordered it at 16, because I was curious after having seen it mentioned in very different contexts, reading it was a life-changing event.

Because this is beyond what your typical high school teachers can discuss, quickly followed orders of biochemistry university textbooks, and thankfully now - a few decades on - I get paid for life-long learning, grateful for each moment of awe.

kmmlng
0 replies
7h30m

How did you manage to secure a job where you get paid for life-long learning?

j7ake
1 replies
13h35m

It might be for the better.

There is a big difference between reading about cool biology versus doing biology as a profession.

Biology is a brutal career that requires an army of hands to realise a vision.

lbeltrame
0 replies
13h3m

Then there are the computational biologists, such as myself. Many have a CS background but some (raises hand) actually come from biology itself (I was a wet lab scientist for a number of years).

At this point I'm thinking I got the worst of both worlds... (I jest! But on bad days I do feel like that)

grzeshru
1 replies
21h51m

I sympathize with the author even if my gripe is different. I’m surrounded by people who read pop science and regurgitate things they have no clue nor conception of. It’s very difficult to have an honest discussion and to ask “what if?” and say “interesting, I don’t know” with people who read books and think they have it figured out because so—and-so said so.

I should have loved curiosity, but what I’ve found are people looking to justify existing thinking.

CoastalCoder
0 replies
21h16m

I should have loved curiosity, but what I’ve found are people looking to justify existing thinking.

Do you find yourself subject to that as well? If so, have you found a way to mitigate it?

esclerofilo
1 replies
18h42m

The HN crowd probably knows that understanding maths concepts is a very rewarding experience. It is also very useful for $Nth grade, because it allows you to apply the principles to different problems than the ones you've seen solved.

However, if you try teaching a "bad at maths" kid how to solve a quadratic equation, explaining how to factorize and why it works is a bad strategy. They _prefer_ using the formula IME. They don't want to understand the concepts, they want to pass their exams, and rote memorizing the formula is a faster/more reliable way to do it.

I'll admit that maybe I'm just a bad teacher. After all, I'm not a teacher, I'm a CS grad who has done some teaching.

But think of the average class, with 40 students. The teacher needs all of them to learn to perform some tasks. He'll choose the one-size-fits all solution, even if it's less beautiful, less motivating for the kids that find maths to be fun.

I'm not saying we should go back to having schools for "gifted kids". They have well-documented problems, and I'm not at all qualified to pick one side of the tradeoff. All I'm saying is that boring biology classes are there for a reason, not just teachers without passion.

Synaesthesia
0 replies
18h36m

I still recommend learning and practicing the proper factorization of a quadratic equation, it's a lot faster than using the formula.

It's quite a bit of extra boring practice but worth it IMO.

bentt
1 replies
19h18m

There is a website called Smart Biology with amazing 3D animated videos of cellular systems. https://www.smart-biology.com/

Pretty cheap for individuals as well: https://smart-biology-academy.getlearnworlds.com/courses

I don't work for them or have any monetary interest in them. They just do very cool work and I'd like to see them get more awareness. I wish we had videos like theirs when I was in school.

victor106
0 replies
4h23m

this is amazing!!!

Baeocystin
1 replies
21h58m

A genuinely engaging read. Thank you for posting it here.

firebirdn99
0 replies
16h37m

James Somers is awesome. Every now and then, I see another of his articles that comes up here. Really great writer, who didn't set out to be one, but switched from a career in tech I believe.

AdeptusAquinas
1 replies
21h48m

Hmm, I'm studying first year biology at uni and they convey a lot of wonder with it. Especially when at the same time you study human bioscience (organ systems, tissues etc) and chemistry for biology the sheer wonder of all the little machines working together effectively by random collisions comes off as magical.

I just wish we had a better way to see it. Some sort of approach that would allow us to observe molecules in real time :| An electron microscope of some very dead extracted material just isn't the same.

nicd
0 replies
21h37m

Fluorescence microscopy is a great tool for this!

trgn
0 replies
2h11m

As a counterpoint, Ligotti in Conspiracy against the human race:

“One cringes to hear scientists cooing over the universe or any part thereof like schoolgirls over-heated by their first crush. [...] it would be nice if just one of these gushing eggheads would step back and, as a concession to objectivity, speak the truth: THERE IS NOTHING INNATELY IMPRESSIVE ABOUT THE UNIVERSE OR ANYTHING IN IT.”

https://www.goodreads.com/quotes/497970-one-cringes-to-hear-...

Entire book is great read btw, no equivocating. The author will use CAPS to hammer home a point. Very refreshing, to read people who have a point to make.

the__alchemist
0 replies
18h2m

Perhaps this is obvious, but if you liked this article, check out the works referenced in it! The Eighth Day of Creation, The Machinery of Life, A Computer Scientist’s Guide to Cell Biology, and GEB are all outsanding.

the__alchemist
0 replies
18h19m

F12 dev tools -> edit CSS -> `body` -> max-width: 1000px

sebstefan
0 replies
8h55m

I discovered this when first learning how to program. The textbooks never worked; it all only started to click when I started to do little projects for myself. The project wasn’t just motivation but an organizing principle, a magnet to arrange the random iron filings I picked up along the way. I’d care to learn about some abstract concept, like “memoization,” because I needed it to solve my problem; and these concepts would lose their abstractness in the light of my example.

I think that's why we see people who've learned to program before college get that much more mileage from their courses

They're not smarter, they've just faced the problems we're trying to solve, which gives them the motivation to care about the solutions they're presented with

sampo
0 replies
21h25m

According to archive.org, this was maybe written in 2020.

rkagerer
0 replies
18h43m

This section of the article was illuminating:

But biology, like computing, has a bottom, and the bottom is not abstract. It’s physical. It’s shapes bumping into each other ....

Hemoglobin ... was shown to be an efficient store of energy because of how oxygen atoms snap into its body like Legos, each snap widening the remaining slots, so that it loads itself up practically at a gulp

Most proteins are like this. The ones that drive locomotion twist like little motors; the ones that contract muscles climb and compress each other. Cells, too, are constantly in conversation, and the language they speak is shape.

It’s keys entering locks: a protein might straddle the cell membrane, and when a cytokine (that’s a kind of signaling molecule) docks with it, it changes its shape, so that its grip loosens on some other molecule on the interior side of the membrane...

richrichie
0 replies
15h21m

I wish my high school biology teacher had asked the class how an embryo could possibly differentiate—and then paused to let us really think about it.

The most fascinating question is "Why" and that cannot be answered or debated in the school setting.

quantrox
0 replies
11h47m

If anyone has any understanding of chemistry it is indeed astonishing. Living organisms managed to develop chemistry in very tough conditions.

All is done in environment full of water. Water itself is good solvent for some reactions. However, in many of other reactions it acts as reagent and before chemical process is started the water needs to be removed. Biochemistry laughs at water. Another thing is the temperature. Considering human (but there are many organisms without internal temperature control, and there is much colder than in our bodies) it is only 37 deg. C. Many chemical reactions are endothermic, they require a lot of energy to pass the activation barrier. In the laboratory we can keep the reaction under the reflux, which means constant boiling for hours or sometimes even days. Another thing is the pH. Some reactions require to be done in more or less acidic or basic environment. Biochemistry also laughs at pH and all is done in 7.4 (considering human). And finally, stereochemistry. It is also very important how the molecule is oriented in space. Things like proteins need to fold in specific manner.

If someone looks on the biochemical pathways they are indeed very complex. But it is not without purpose. It is amazing.

openrisk
0 replies
20h20m

Biology is interesting and intellectually attractive without having to try too hard but the way it is typically taught is off-putting for the more mathematical types.

Which is a pity. Biology is the very definition of complexity science and while more fundamental physics research becomes increasingly esoteric and unproductive, life sciences provide an opportunity and a tangible challenge to invent new mathematics and computational tools that are a quantum leap versus our current toolkit.

E.g., morphogenesis has attracted people like Alan Turing and Rene Thom but it feels that there is still a vast universe to be understood more fundamentally and accelerating that pace might be even of vital importance for our welfare.

ojbyrne
0 replies
15h0m

Another anecdotal data point: I took biology first year of college and we had labs where we looked at things under a microscope and draw what we saw. And for whatever reason - inability to draw, difficulty focusing on what I saw, or that things moved, I just couldn’t do it. We were required to pass the labs to pass the course. I ended up dropping the course.

mogoman
0 replies
9h34m

As others have mentioned, this resonates well. But for me, not only biology. Looking back, I wish my history teacher had done something similar; taken me by the shoulders and shook me until I really understood what we were learning. Instead, major events in our history ended up being "memorize yet another date" rather than us understanding the impact these events had on us or our parents/grandparents.

minmax2020
0 replies
12h31m

Watching Dr. Eric Lander's lectures in MIT OCW Biology course was a watershed moment in my life. I felt exactly the same way as this blog post after finishing the course, two years after graduating from college. Highly recommended if you haven't seen it yet: https://youtu.be/P-Ry4rRdDbk?si=Hp2SEkEKGeeui-pP

matrissian
0 replies
18h14m

biology bored me as a kid, but now it's fascinating. life is lovely.

mandibeet
0 replies
20h9m

I think the love for school subjects largely depends on the teacher

littlelady
0 replies
9h15m

I feel very lucky to have had very talented and passionate teachers in my K-12 education. Their enthusiasm for their subjects was infectious!

I'm currently tutoring a pupil who isn't so lucky. Trying to get her interested in the dry material that she has to do is by far one of the greatest challenges and has required me to generate an interest in it that I can pass on to her.

kwhitefoot
0 replies
21h58m

One might just as easily wonder why they needed to be told to have a sense of wonder.

kevbin
0 replies
17h10m

Who needs someone else to tell them what’s interesting?! Isn’t “Golgi apparatus” enough to get you going? If you’re relying on a teacher—or some blogger,for that matter—-to call out everything that’s worth finding out about, you’re going to miss a lot of stuff & most of the really good stuff.

jdwyah
0 replies
16h42m

“But no one shook me by the shoulders, saying how crazy that was.”

If you’re lookin for a book that has absolutely kept this sense of wonder, “Immune” by Philipp Dettmer has this in spades. Highly recommended.

incompatible
0 replies
12h0m

"... was like a small Lisp program, with macros begetting macros begetting macros, the source code containing within it all of the instructions required for life on Earth. Could anything more interesting be imagined?"

Interesting, but in the head-mangling way of debugging complex TeX macros, or the original sendmail.cf. Avoid, if you value your sanity.

imhoguy
0 replies
8h41m

I didn't love biology in school, but I was luckily bored after school and watching "Il était une fois... la vie" and other series. Learning must start with fun. https://www.imdb.com/title/tt0284735/

globular-toast
0 replies
8h25m

I thought the same when I went into a computational biology role and crammed virology for a few weeks before applying. I thought biology was about types of plants and animals. You know the stuff: label the parts of a flower, how many legs does an insect have etc. When you learn about viruses you have to learn the super low level stuff like DNA replication. I saw a video of DNA replication happening, it's like a little sewing machine going through and cutting up the molecule and joining it back together! And it's a code! What's not to like?

But after a couple of years in the role I realised I was at a major disadvantage. The good people in biology actually do like and know the rest of it too. I was working on projects to do with plant biology. I did my bit. But the others came in to the greenhouses to tend their plants during the night on a weekend. They'd talk about high-level concepts that I just had no idea about. I was never going to be as passionate about it as they were, so I was never going to succeed.

So yeah, do learn this stuff because it's amazing and unbelievably fascinating. This is a great article to whet your appetite. But there might be a reason you didn't love biology in school!

foobarbecue
0 replies
20h46m

My high school biology teacher (Ms Dinnetz, Kungsholmen's Gymnasium) was absolutely amazing. She had a way of really briging the material to life, or rather, to death. That is, every time she taught us a new concept she would describe the way we'd die without that concept. An extremely memorable class.

divbzero
0 replies
16h53m

Using just a centrifuge, water, detergent, and acid, he purified nucleic acid from his smooth strep culture. Precipitated with alcohol, it became fibrous. He added a tiny bit of it to the rough culture, and lo, that culture became smooth in the following generations. This fibrous stuff, then, was “the transforming principle”—the long-sought agent of heredity.

I guess that’s why we still call the process of bacteria taking up DNA “bacterial transformation”. It was the terminology they used early on.

czxtm
0 replies
13h13m

Articles like this are why I visit HN - most days HN feels like the equivalent of quickly skimming my email inbox - but every once in a while there's a gem like this article that moves me deeply

analog31
0 replies
3h44m

A problem with being inspired is that each of us is inspired by a different aspect of a field. For instance, I fell in love with math because of abstractions and proofs, the things that most students hate.

I didn't need to be shown what math was useful for.

alextheparrot
0 replies
14h51m

I love the romance of this piece, but in my experience he’s just describing the difference in expectations of learning biology at a high school versus advanced undergraduate to graduate level.

Romance is for those who care, and most don’t. But it is so, so beautiful once you do.

VladimirGolovin
0 replies
8h18m

> People ought to be walking around all day, all through their waking hours calling to each other in endless wonderment, talking of nothing except that cell.

That's exactly what I did, for a year, after reading The Selfish Gene.

Ozzie_osman
0 replies
16h42m

Not biology, but I had a great astronomy professor in high school and fell in love with the topic. The vastness of the universe, the physics behind it. How people measured the distance to a star or the curvature of the earth.

Then I got to college and was effectively told, if I studied astronomy, I'd end up in academia perpetually and I wasn't ready to make that commitment. So I fell back to CS. And sometimes I wonder....

Myrmornis
0 replies
3h50m

It's easy to agree with the sentiments in the first half of the article about how biology is taught uninspiringly. However, I can't help noticing that the biology student in the article evidently became a computer programmer later in life (I followed the same track), and probably is paid more than the biology teachers of their teenage years. So it's a bit uncomfortable to see them sniping at their former biology teachers from their position later in life. As with many conversations on such subjects, it feels that it's going to end up at "teachers aren't paid enough".

BroomOfSYS
0 replies
21h21m

This is probably true for almost every subject, I found myself hating chemistry in high school mainly due to a bad teacher, but then I watch thiings like red nile on YT and am amazed hor funny this subject is.