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FDA clears first over-the-counter continuous glucose monitor

philsnow
87 replies
1d2h

I dove into CGMs a little bit about a year ago, mostly just for fun. Yes, I paid money to some online prescription mill for CGMs (Abbott Freestyle Libre 3, IIRC), and then put one in my arm (the applicator is a short syringe section that has the monitor tube threaded into it, so the tube stays in your arm and your skin under the monitor remains broken) for a couple weeks. Just to see how various foods would affect my blood glucose, to see whether the “facts” I’m telling my kids about the glycemic index of various foods actually has the expected impact on a measurable result. You know, as you do. For fun.

(It actually was fun, and I’ll do it again when the data ecosystem improves.)

haswell
50 replies
1d2h

Aside from the fun, how did it go? Find anything surprising or insightful in the process?

It sounds like an experiment I’d like to do for the purpose of optimizing my daily habits and establishing a better mental model for how my eating habits impact me throughout the day. But I really dislike needles.

smt88
38 replies
1d1h

If the needle in the CGM bothers you, don't let it. It's a quick, painless jab with a tiny needle at the beginning and then the needle comes out. The part that stays in your body is just a flexible filament made of plastic.

I did this experiment as well, and the main thing it did was completely stop me from snacking. My habits got better because I could see how my BG could never return to baseline if I allowed myself to snack between meals.

Other than that, it was also interesting to see certain things would badly spike my BG and other things wouldn't, and they weren't always what you'd expect. A lot of "keto" and "diabetic-friendly" products are terrible for most people's BG and were for mine. I found that some things, like black tea, actually made my BG drop as well.

Overall it's worth doing at least once.

TaylorAlexander
26 replies
1d1h

My understanding is that for healthy individuals, spiking blood glucose levels is not a problem. Did you get in to any of the research on that? Glucose is a problem for diabetics because they can’t regulate it, but healthy people can. At least this is loosely what I have heard, somewhat third hand. Any information is appreciated.

pie420
18 replies
1d1h

Not a doctor, but from what I have seen, there is a healthy amount of spiking from eating normal foods, but our modern diets are so sugar and carb heavy that the glucose spikes are way outside the range that our bodies evolved to handle. Hunter gatherers would maybe eat some berries here (much smaller and less sweet than modern berries) and there. The modern human eating pizza, tons of bread, ice cream, soda, etc. creates such massive glucose spikes that they are unhealthy and unsustainable for the pancreas to handle for 60+ years.

Again, not a doctor and not sure if this is accurate, but this is my very limited understanding

throwup238
14 replies
1d

> Hunter gatherers would maybe eat some berries here (much smaller and less sweet than modern berries) and there.

Archaic humans had access to plenty of wild fruit that were high in sugar and tubers that were high in complex carbs. They even had access to concentrated forms of sugar like sugarcane and honey.

They obviously didn't have refined sugars in everything they eat like we do but that they had access to limited sugar in the form of berries is a persistent myth. They would have been exposed to large glucose spikes regularly whenever they came upon a new tree that was in season while migrating.

CadmiumYellow
8 replies
23h32m

Not to mention humans 150 years ago who ate plenty of bread and still didn't have the problems we have with obesity and diabetes. Or even 50 years ago...

NoPicklez
6 replies
22h20m

That could also be because a fair amount of the bread in supermarkets today is closer to confectionary than homemade sourdough.

EasyMark
5 replies
19h29m

light bread starts turning into sugar almost instantly in the mouth and stomach. It's only one step removed and saliva can break it down quickly because it has amylase. Sour dough and whole wheat/grain breads tend to break down a bit slower. You can freeze bread overnight and make it a bit more "resistant" to breaking down quickly and I pretty much do this with all my breads along with toasting them a bit for sandwiches. Pasta can similarly have its glycemic index lowered by first making it "cold"

int_19h
4 replies
17h15m

Do you mean that they need to be cold when they are consumed, or is it the process of freezing itself that does something, even if it's later reheated?

imp0cat
2 replies
14h1m

The process of cooling down converts starches in rice, pasta, potatoes etc... to a more resistant forms that your body cannot process easily.

thimkerbell
1 replies
7h46m

Does chilling also work to convert bread starches into resistant ones, or does it only work for rice and potatoes?

amanaplanacanal
0 replies
10h18m

They don’t need to be cold when consumed.

TylerE
0 replies
12h16m

That’s not really a fair statement. Many problem who would die of diabetes today would have died of something else 200 years ago long before the diabetes got them. Non-juvenile diabetes is a slow killer, it’s really hard for it to kill you before the age of reproduction.

A diagnosis today that is imminently manageable like asthma was far more readily in a world without antibiotics, steroids, or even medical oxygen.

Even something like a CPAP that many of us take for granted has only been readily available for 30 years or so.

Plus, diabetes is much like AIDS in that it’s more of a systemic thing than acute. It doesn’t really have symptoms that kill you. It just slowly weakens your body until your heart gives in, or you have a serious infection, or something like that. No one dies “of” diabetes, they die with it.

amenghra
2 replies
1d

We live 2x-3x longer than we used to. We should take the best possible care of our bodies.

Fricken
1 replies
19h58m

Only as a statistical average. Hunter gatherers who survived past age 5 had a good chance of living into their 60s and 70s.

cableshaft
0 replies
23h24m

They also moved around more than most people do today. Most of us are stuck sitting pretty much all day in front of a computer.

EasyMark
0 replies
19h40m

fruit and berries do have sugars but in their wild state they tend to have much less than their modern equivalents bred to be sweeter and tastier. Even then they still typically are 75-95% water and often have some fiber, antioxidants, and vitamins which all can help with inflammation unlike snickers bars.

jablongo
1 replies
21h27m

It's not really that the pancreas itself can't handle it (though this may be true also). What happens is that having high blood glucose, even if it's not continuously high, is just bad for you by virtue of the high concentration of glucose in your blood. Having high blood glucose leads to the creation of "Advanced Glycation Endproducts" (AGEs) which bind to certain receptors (RAGEs). The AGE-RAGE interaction is linked to downstream diabetes side effects like atherosclerosis.

philsnow
0 replies
21h12m

There's also research that indicates that cancer thrives in high-glucose environment, and that starving cancers of glucose reduces their size over time.

watwut
0 replies
23h48m

I have better life expectancy then them.

Attummm
1 replies
13h45m

Well, they're not just people. They are longevity scientists.

1234letshaveatw
0 replies
4h30m

longevity scientists are just people

pcorsaro
1 replies
1d

I'm not the OP, but I had a CGM several times through Levels. I can tell you that the major spikes (glucose over 200 after sitting between 80-90) really made me feel like shit. The 2 times I can remember it getting that high were when I had too much sushi, and a huge bowl with white rice from Chipotle. Brown rice never seemed to spike me nearly as bad, especially if paired with something high in fiber like black/brown beans. From a long term health perspective, I have no idea if it's a problem or not. I didn't like how bigger spikes felt, so there's probably something to it being bad for you long term. Obviously the more often you spike as a "healthy" person, the less sensitive your body is to insulin. Staying even on my glucose levels is always where I felt the best.

EasyMark
0 replies
19h43m

straight rice and bread break down into sugars -very- quickly in the stomach, that's why mixing them with stuff like you mentioned (heavy in fat and/or protein) can really dampen the spikes in my own observations. Those are just anectdotal though and what works for me doesn't work for everyone. I do like to eat a salad first with some good fibrous veggies though OR something like eat some of a chicken/fish entrée or steak if I'm having that as part of a meal.

smt88
0 replies
17h28m

My A1c is right on the edge of prediabetes, so I wasn't as concerned about the spikes as I was about my baseline, how long spikes last, etc.

T1DTech
0 replies
23h35m

With Type 1 Diabetes, your pancreas is no longer producing insulin, with Type 2, it's typically that it's not producing enough insulin. My child is healthy, but his pancreas stopped producing insulin years ago. He lives with T1D.

coffeebeqn
8 replies
1d1h

Where do you put the needle thing? Does it get in the way of everyday things?

pastage
2 replies
1d1h

No it never gets in the way. I would not recommend doing it unless you are a diabetic, the results are not that interesting. It took me two years to get used to smacking that needle into the upper arm/stomach/leg, spending up to 20 min -40 min getting over the fear was not a fun time.

RecycledEle
1 replies
1d1h

I feel for anyone who has both diabetes and a fear of needles.

Having said that, it's no bug deal for 90% of people.

Projectiboga
0 replies
23h14m

T1D here, needles are nothing compared to everything else an insulin dependent diabetic deals with. I guess only maybe 1 out of less than 100 shots hurt that much. It only happens when a nerve bundle is hit, then it smarts but it is still less bad than either high, or low blood sugar as well as how insane most every part of American 'health care' is. The main tricks for comfort are go with 29 gauge not the narrower more fragile types with the higher number gauges. The narrower ones have more fragile needle points and they can get damaged by bending during the insertion into the bottle. The other trick is to make sure the alcohol is dry before you take the shot.

singlow
1 replies
1d1h

Typically it is on the back of the upper arm where it is covered by a short sleeve shirt. Generally it does not get in the way.

RecycledEle
0 replies
1d1h

I also use a piece of kinesiology tape to make sure my CGM does not fall off.

xen2xen1
0 replies
1d

I keep mine on the front of my upper arm, where I automatically notice and protect it. The back of my arm usually means it's off in a few hours.

RecycledEle
0 replies
1d1h

The needle stick a flexible tube in a few mm, then the needle pulls out.

Think of it as a 5mm thick patch and ignore the tiny tube sucking your blood.

Aqua_Geek
0 replies
1d1h

The sensor typically goes on the back of your upper arm (your tricep). You can accidentally bump into things with it, but it was infrequent enough that it didn’t bother me.

The needle is only used in the application of the sensor. It’s spring-loaded and retracts after the sensor is attached. I hate needles, but I found that the tape on the sensor provided enough stimuli to overwhelm my brain and not really feel the needle when it went in.

philsnow
0 replies
21h14m

A lot of "keto" and "diabetic-friendly" products are terrible for most people's BG and were for mine.

Absolutely, there are a lot of companies trying to cash in on this new-ish market, and they'll do anything to their products to get the net carbs down to 0-2g "per serving" -- scare quotes around that because this is a particular annoyance of food labeling in the States: food labels declare the amount of various nutrients per "serving", but 1) they get to choose the serving size [0] and 2) they get to round numbers, so if they just pick the serving size such that it's 1.499g of carbs per serving, they get to put that it's "1g", and so on.

It makes it impossible to compare food labels between different items even among the same manufacturer (and even the same SKU but different/later packaging, because they don't have to issue a new SKU when they change the food label). If instead they were required to show amounts in g per kg (or ml per l for liquids, or whatever), they could be compared more easily.

[0] The FDA provides "Reference Amounts Customarily Consumed" and asks manufacturers to refer to them when deciding their serving sizes, but (from [1]):

FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidances describe our current thinking on a topic and should be viewed only as recommendations [...]

so really they can pick almost anything they like

[...] unless specific regulatory or statutory requirements are cited.

unless the food is medicinal in some way, I guess?

[1] https://www.fda.gov/media/102587/download

haswell
0 replies
23h11m

That's good to know. I think my aversion to needles is so strong that it stopped me from going beyond basic research. Bad on me.

But this does sounds like an interesting thing to try, if only to get a better idea of how my body works.

I've been tracking walking vs. resting heart rate, HRV, blood oxygen levels, and sleep for a few years using the Apple Watch, and while I know these measurements are imperfect, they've helped me better understand the impact of certain choices.

There's something that seems really beneficial about feeding my brain data about myself as a way to do the healthier things I've always wanted to want to do. The more data I have, the easier it feels to implement positive habit changes in a way that doesn't involve sheer willpower. There's something very satisfying about seeing the very tangible changes on a graph over time that indicate better health, even when it doesn't feel like the changes have done anything noticeable yet.

pastage
5 replies
1d1h

If you want to know more about it you can just read about how diabetics treat different foods. Short version; high GI is fast high blood sugar, lots fat and sugar can results long period of with high blood sugars.

It is a CGM more or less what you would expect, insulin is the only hormone that lowers blood sugar, then you have all the stress hormones that raise it like adrenalin, growth hormone and cortisol plus glucagon for long time storage of sugars in the body. So measuring blood sugar with a CGM gives you a value between 2.9-13.5 mmol/liter that is supposed to give you picture of a rather complex system. A CGM also needs perfect access to your free flowing blood which in it self is a difficult task.

haswell
2 replies
23h23m

I'm more curious about the experience a non-diabetic person has. For one, the purpose of using the device is quite different, and not related to a life threatening situation. And because the focus isn't to manage this specific issue, the insights and potential utility seem like they'd be of an entirely different variety.

e.g. I know that the things I eat impact my blood sugar, but don't have the same kind of intimate awareness a diabetic person would have, nor would the changes in my levels have the same meaning/impact.

Put another way, and setting aside the issue of oversimplifying a complex system (so is measuring RHR, HRV, blood oxygen, etc.), the benefit of CGM for a diabetic person is obvious. The benefit of CGM for a curious person less so.

pastage
0 replies
19h40m

It is probably easier to find interesting things curious people with diabetes has done, sure you might want help to sort out the interesting bits.

Optimizing sugar in take for exercise might be an interesting thing todo as non diabetic. There is no tool to continuously measure ketons though which is the fun part. CGMs are so slow. I really see no use at the moment.

Projectiboga
0 replies
23h11m

Main benefit is more data, only work is to accurately log meals and activity.

eternauta3k
0 replies
4h1m

A CGM also needs perfect access to your free flowing blood

I thought CGMs measure the interstitial fluid?

EasyMark
0 replies
19h18m

I'm asking out of curiosity here: I've always heard that fat doesn't spike your glucose at all and protein only if you a considerable amount of it. So from what you said if you ate a fatty cheeseburger (plated like a steak and without the bread) that your blood sugar will spike? I'm currently doing a Mediterranean style diet during the week and slacking off a bit on the weekends friday evening through Sunday morning. I have done keto in the past though with the readings I've done on it saying that lots of fat, some protein, and just a little bit of carbs should basically keep any glucose spikes very low. I could only handle the keto for a couple months though.

philsnow
1 replies
21h28m

I almost completely forgot about the monitor itself, and only paid attention to the numbers on my phone. It's that unobtrusive (at least the Libre 3 one that I used).

I let the needle (actually: annulus? see sibling comment) get into my head because I was curious and looked at it. It looks a lot scarier than it is, kind of like using contact lenses for the first time: before you've used them, you get into your own head about it, but once you've done it a couple times it's just rote and easy.

I had started the first one a day before I started a few weeks of (6-days-on, 1-day-off) keto. Keto guides will say that you should have <= 25g net carbs per day, but I specifically wanted to see how front-loading (having almost all the day's planned carbs in one meal) affected blood glucose, and also whether the number (25g) is accurate for my physiology. I found that my number was closer to 30g and that when I stayed under it, my blood glucose spikes had very short duration but when I went significantly over it, blood glucose stayed higher for longer.

edit: One more thing, I used this time to play around with various sugar substitutes and see how they affected my blood glucose. Allulose came out as the winner (if money is no object) based on not having any noticeable off-taste or aftertaste and on measuring gram-for-gram the same as sugar (well sort of, it's only like 80% as sweet as sugar, so you get the same mechanical effects of sugar if you weigh it gram-for-gram and your baked goods or whatever come out not quite as sweet, which is perfect for me. Creaming butter with liquid stevia extract or something just plain doesn't work.

LegitShady
0 replies
17h25m

what other sweeteners did you try? Can't get allulose in canada (unless you buy it from a shady importer) because Health Canada says there isn't enough data to say its safe, so its not approved sweetener.

galago
1 replies
1d1h

Freestyle Libre 3 only has a plastic filament and the plastic applicator pushes it in without pain. Very different than metal lancets (stick test). I can't feel it at all when its in the back of my arm. If I were worried about sweating too much and it not sticking I would get one of the third party over-patches that create a lager adhesive area. I might do that in the Summer.

spc476
0 replies
1d

My girlfriend uses the Libre 3 and I was wondering how it worked with just that plastic filament. She doesn't feel it at all when I apply it. We found that if she washes the area with soap and then just relaxes her arm and lets it hang freely, I apply it to the back upper arm, it just stays on and doesn't get in the way.

crimsontech
0 replies
1d

I did it for fun about a year ago and found out I had T2 diabetes.

I was shocked but obviously glad I found out. I use them from time to time just to see how I’m doing and how different foods (and amounts of them) impact me.

I found I can control it through diet alone and exercising when there is a spike by using a GCM for the constant feedback.

They are very expensive here though (UK) and my doctor won’t prescribe me one because metformin is cheaper, so it’s not something I can use all the time.

I hate needles, this really isn’t like a needle though, it’s a small filament which sits just under your skin, you can’t feel it, I thought it hadn’t gone in until I saw the reading appear on my phone.

Some things I found out besides what foods and amounts give me big spikes are that I have a blood glucose spike in the morning just before I wake up, and that if I eat a small enough portion of white rice, ice cream, bread, whatever I can reduce the spike quickly by going for a walk. If I had a lot though, a walk isn’t going to help.

jseliger
15 replies
1d

Before I got cancer, I had one through Levels, and it was informative. Dessert is much worse than I'd thought. Rice, too, including brown rice. I remember eating some biryani and a small bit of naan at an Indian restaurant and thinking that I'd been pretty healthy, only to see a spike of like 80.

meindnoch
3 replies
1d

Momentary high blood sugar is perfectly fine after eating carbohydrate-rich meals.

Retric
1 replies
23h22m

This was down voted, but it's all about the time scale. A major pathway of transporting energy from your food to your cells is via glucose in your blood and your cells then use or store it for later. Insulin production reduces the spike, but that response isn't instantaneous.

So on a second by second basis numbers that would be concerning across an hour are fine. Similarly your average over an hour post meal can be much higher than a healthy average across a day.

TylerE
0 replies
21h2m

Yup. A1C, which is the main diagnostic measure, due to the way it’s measured is a roughly 90 day moving average with somewhat of a recency bias.

Like most things, it’s mostly about area under the curve, as long as the extremes aren’t too much so.

EasyMark
0 replies
19h51m

for sure, the length of the spike is just as important, it's like energy and it's an area under the curve type of phenomena

al_borland
3 replies
22h2m

I saw an interview a while back between Tim Ferriss and someone who had tried CGM for fun/research. One thing he noticed was the huge impact a short walk after a meal brought down his blood sugar levels. Tim then mentioned he experienced the same thing and that there is a saying in China, something to the effect of, "take 100 steps after a meal, live 99 years." This also linked up with something I had looked up a few years ago when I noticed that I always saw families of Indian decent walking around neighborhoods, but never anyone else. I looked it up, and founds there is a word in Marathi of taking 100 steps after a meal. (https://en.wikipedia.org/wiki/Shatapawali)

It seems there has been this age old knowledge that taking a short walk after a meal is really good for you, which somehow got lost in some/many cultures. My parents would always say they had to sit after a meal to let their food digest... it never really made sense to me. My grandma, on the other hand, is 103 and gets pretty upset if people try to stop her from walking after a meal (or whenever she wants). We always just thought she liked walking, but maybe there is something else driving her, it seems to have worked out for her. It was very interesting to hear the CGM back up some of these practices that have likely been going on for hundreds or thousands of years.

I have been wanting to try one. This approval opens up the door. I think seeing something like this with my own eyes, with my own body, with actual numbers, would have a bunch bigger impact than some anecdotal stories from others and nice sayings which align.

It looks like there is some research being done in the area as well.

https://link.springer.com/article/10.1007/s40279-022-01649-4

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912639/

neeleshs
1 replies
20h22m

Taking 100 steps after a meal is a common saying in India as well. The saying also advises sleep on ones left side for good health. Goes like this in Kannada - "Undu nooradi nadedu, edamaggulagi malagidare vaidyana bhandatavilla sarvajna"

Literally "if you walk a hundred steps after eating and sleep on you left, there won't be any doctor's shenanigans"

EasyMark
0 replies
19h52m

sleeping on your left side can help with gastrointestinal issues somewhat (like reflux) or after eating an acidic dinner.

philsnow
0 replies
21h38m

That's fascinating -- you know how your body sometimes manifests a craving for a food when it "knows" that you're deficient in some nutrient that food will provide?

I get the same feeling (of my body directing me to take some action) but it's not after meals, for me it's after having more than one beer. After 2-3 beers I want to go walk around the neighborhood for half an hour (and it's a bummer when the neighborhood is not pedestrian-friendly).

illegalsmile
2 replies
23h28m

Desserts can definitely send your levels quite high but I don't think I'd qualify some biryani and naan with a reading of 80 as unhealthy. You probably ate a healthy portion and left it at that. Is 80 not well within the normal range?

pastor_bob
1 replies
22h59m

He probably means it spiked 80 from where it was (e.g. 100 to 180)

TylerE
0 replies
21h0m

Which is still pretty normal, low for a full meal if anything, if not presiding with insulin.

o_____________o
1 replies
20h15m

Eat fiber first. Add more protein. Eat reheated rice (resistant starches). Isn't it interesting how much these little details matter?

EasyMark
0 replies
19h48m

healthy proteins and fats are good for you, both will slow down digestion time. I rarely eat only rice as the main course of a meal, and usually eat something either with it or before it, and it's almost always brown rice.

colordrops
1 replies
23h30m

Is 80 high? That seems totally fine.

TylerE
0 replies
12h18m

80, as an absolute reading, is on the low side of normal. Like, that’s what it might be first thing in the morning before you eat. Anything sub 50 starts to get dicey.

itpragmatik
9 replies
1d1h

At least for me the readings that it shows are not accurate (when verified with old style finger pricking glucose monitoring machine). These CGMs are good for knowing the general variability of glucose level in your blood based on your diet exercise etc; I don’t trust the absolute numbers from CGM like Freestyle Libre - haven’t used any other one though yet.

reaperman
3 replies
1d1h

It would be interesting to see whether a group of 20-100 people could manually calibrate their readings by fitting their CGM readings to their fingerprick glucose readers. I wonder what the accuracy would be after a very basic personal curve fit.

I do this with a lot of consumer measurement devices. Both for thermometers and scales (food, human, and cheap 0.1mg scales). As well as thermostats, like the kitchen oven. I also do it for my multimeters. I validate my volumetric measuring cups/spoons by weighing water in them but I don’t correct them, just return if they’re way off.

It’s okay if the reading is off as long as I can correct it the same way every time and get a pretty accurate result.

alright2565
1 replies
1d1h

Calibrating my scales and thermometers would be nice. What procedure do you use for it? is it documented online anywhere?

reaperman
0 replies
1d1h

I basically use an Excel sheet. Make a scatter plot of the "true" values on one axis, and the "measured (slightly wrong)" values on another axis. Then do best-fit to y=mx+b and manually adjust it according to that equation using my phone calculator in the future.

Some classically trained engineers may tell you the "true" value should always be plotted on the x-axis as it is often considered to be the more "independent" variable...but this is highly debatable, and you can skip some simple algebra later if you put the measured value on the x-axis. Then look at the shape of the scatter plot. Ideally it will be linear, so you ask Excel to do a linear curve fit (y=m*x+b). Write this on the scale, and now whenever you take a measurement on the scale, whip out your phone and do "measured_value * m + b". And that's your true value. If it's not a linear fit (quadratic, log, etc) ... that's interesting, and often it's likely "wrong", but also "it is what it is". Classically trained engineers will say you have to do a linear fit if that's what the theory says is appropriate, but for one-off home device calibration...do whatever works for you. Just as long as you don't overfit with some stupid 4, 5, 6, etc-term equation. Any reasonably simple equation with 2-3 terms is fine IMHO.

I use a set of heavy objects whose mass I know fairly precisely. They're not perfectly 10.000lbs, 20.000lbs, etc ... they're just "around 10lbs, around 20lbs" and I've used a good actually-calibrated scale (at work, some commercial business with calibrated scales that you can access, whatever) to weigh them and wrote their weights in sharpie on a piece of tape stuck to the objects. Ideally you'd go for around 10% increments. If the scale can weigh 400lbs, that would be every 40 lbs or so. But it really doesn't matter as long as you have enough good points around the range you truly intend to measure, and then a few outside of that target range at semi-regular intervals.

For my 0.1mg-resolution mass balance I have some actual calibration weights, but they're a relatively affordable OIML "M1" class, and did not come with expensive calibration certificates. The OIML tolerance ratings go E1, E2, F1, F2, M1, M2, M3 (from best to worst). For a 100g test weight, M1 precision gets you +/- 0.005g, guaranteed, for $50 ($135 if you want a calibration certificate). E1 gets you +/- 0.00005g at 100g test weight, for $500 ($1200 with cal cert). For smaller calibration weights like 10mg you'll generally want to go a step up from M1 (+/- 0.25mg) to F2 (+/- 0.08mg) for about $27.

For temperature, it's a bit trickier because the only "true" temperatures you can create are -6°F/-21°C and 228°F/109°C. If these temperatures are helpful to you, you can create them by pouring shitloads of salt in water and stirring+heating it until no more salt will dissolve and you just have a pile of salt in the bottom of the container. You can try to go for "0°C/100°C" using distilled water and it would probably be close enough but you can't know it exactly unless you use super pure de-ionized water and use extremely absurd lab technique (usually involving washing your glassware and tools with de-ionized water over and over for several days straight to get rid of trace contaminants).

So instead, to get "true" temperature in the range I care about, I use some thermocouples attached to a high-quality multimeter or oscilloscope. Then I calibrate these thermocouples using the method above, and average their reading for the oven temperature. This works and extrapolates well enough outside the range of calibration because the error of a thermocouple is basically guaranteed to be a very linear error.

In this link[0] topics 1-6 ("weeks") get into the fine details of all this and provide some worksheets/excel sheets already made up for this type of thing. If you're really getting into the weeds with this, understanding propagation of error[1] really helps but is super unnecessary for 99% of people unless they're doing actual engineering.

0: https://pages.mtu.edu/~fmorriso/cm3215/laboratory_exercise_s...

1: https://pages.mtu.edu/~fmorriso/Pintar_Error_Analysis_or_UO_...

ksaun
0 replies
15h27m

The entire system is too complicated, and the CGM too variable in accuracy, for such calibration to work in the way I think you are suggesting.

Each time the CGM is applied, the situation is different because of the exact position and various other factors. And the CGM is not 100% consistent.

You do/can calibrate the CGM as needed. For example, when the CGM first activates, standard practice is to check with a fingerprick to see how accurate the CGM is this time and (sometimes) calibrate. (As noted in other comments, the CGM and fingerprick are not detecting exactly the same thing.)

And the next time you apply the CGM (we use a Dexcom G6, which is changed every 10 days), any previous calibration is irrelevant. There's a lot of variability and many factors that can affect results (exact location, scar tissue from previous CGM application, recent exercise, a recent hot shower, etc.)

(I didn't explain that well, but hopefully you get the idea.)

pastage
0 replies
1d1h

This is highly personal thing it is apparently very inaccurate for some people, I've never been below or over dangerous levels without it giving a warning. What has happend once or twice over the decade I've used it is that it will get stuck in a bad reading, so you do not see the variations. It has always got unstuck when I've gone below 3.5 mmol/liter or so.

mlsu
0 replies
1d

It actually may actually be the other way around, at least for newer CGMs.

Try doing a few fingerpricks in a row. The variability will surprise you!

jablongo
0 replies
18h30m

Another reason they are sometimes different is because there is a lag in the CGM data. It's estimated the lag is about 12 minutes.

gumby
0 replies
22h23m

Apart from the latency of diffusion from bloodstream to interstitial fluid (and the lower levels in the interstitial fluid) the FDA requires that consumer devices be with 20% of the venipuncture level.

That means a lancet poke can be quite different from a meter like the freestyle, and both can be quite different from the level in your veins that a lab would get. So if your level is 200 one device can read 240 and the other 160 and both can be considered “correct”.

I found that the freestyle libre 2 and libre light are characteristically low while the FS 3 is characteristically high. So I use them for the shape of the curve, and that is useful.

Engineering-MD
0 replies
22h50m

There is generally a latency of a few minutes between blood and interstitial fluid (the CGM) readings- up to 15 minutes. You may find if you account for latency your consistency between the two increases

znpy
2 replies
1d1h

What's the lifetime of a single device? Are you supposed to remove it before a shower and reapply it later?

hlfshell
1 replies
1d1h

No, it's mostly water proof. You wear it through showers and even swimming for 2 straight weeks. The adhesive is pretty good; rarely does it come off on its own prior to say, a week and a half in.

It holds 8 hours of data (1 reading per minute) and you can just hold up your phone to read the last 8 hours of data for your overall data.

znpy
0 replies
23h55m

thanks for the reply!

barbazoo
2 replies
22h53m

What symptoms would one have to present for an "online prescription mill"/"virtual care provider" to prescribe a CGM? I'm fascinated by this and would love to try it out but I don't want to bother my family doctor with this.

CaptainNegative
1 replies
20h10m

The only symptoms needed are a pulse, the ability to type out a credit card number, and availability for a sham phone call. It's virtually impossible to not get prescribed one from a mill.

EasyMark
0 replies
19h15m

How much would a month or two cost me if it was out of pocket? I wouldn't mind doing it for science.

gregschlom
1 replies
1d

so the tube stays in your arm and your skin under the monitor remains broken

That's not how it works, at least for the Freestyle Libre 3. The cross section of the needle has C shape rather than a O (technically I believe it's called a cannula). When you remove the applicator that C shape allows the needle to be removed through the hole at the top of the sensor, and only the flexible filament stays I your arm.

rnewme
0 replies
17h59m

I belive he called the flexible filament "tube" and that you are both saying the same thing. Ie skin stays open (albeit in very tiny spot where the filament is sticked in)

turtlebits
0 replies
1d1h

Same, but my doctor pointed me to a promotion for a free sensor. It did require a prescription, but since I don't have diabetes, it's not covered by insurance.

Trying to get it filled and picked up was slightly annoying as the pharmacy initially did not want to fill it without some prodding, and I waited a while for them to figure out how to get the promotion billed.

hasty_pudding
0 replies
1d2h

I would love to see the results of that!

anonfornoreason
72 replies
1d1h

I would recommend anyone to experiment with this. I did, and found out I was more glucose sensitive than I expected. This led me to get more broad labs done, with which I was able to find additional treatable issues that are likely the cause. If I hadn't done this, I would have found out via symptoms years later, after irreversible damage had already been done.

You are your only medical advocate, no one else is going to do it for you. The standard of care is shit, don't rely on it.

Aaronstotle
26 replies
1d1h

This is why it made me upset to see this Doctor on TikTok telling people unless you have Diabetes, you don't need a glucose monitor and making fun of people who had one.

Where is the harm in getting data on how your own body deals with glucose?

queuebert
19 replies
1d1h

False positives in medicine can cause unnecessary interventions that carry their own risks. Believe it or not, there is an optimum level of ignorance for maximum health.

eurleif
7 replies
1d1h

If having more information leads to worse outcomes, that's fundamentally a problem with how you're responding to the information, not with having the information.

user_7832
2 replies
1d

If having more information leads to worse outcomes, that's fundamentally a problem with how you're responding to the information, not with having the information.

Not necessarily.

Rohin Francis (Medlife crisis) has I think a video on overtesting, but for example, if you have a new technology that tests and suspects a tumor, which results in CT scans for patients, if millions of users use this tech there's a likely non-zero number of people who may get cancer from the CT exposure.

"What about those who actually had the tumor?"

Well it's possible that 99% of these cases would've been symptomatic anyway in a few more months.

By explanation isn't the best, but over-medication is not a non-issue.

graeme
1 replies
23h47m

That's still the response though. You can simply say "Well, we expect an error rate of X with this new test, so in the absence of other risks factors we predict the actual odds of the condition are Y".

Then you can decide whether a test makes sense or doesn't make sense, given the tradeoffs of radiation and cost vs. the risks of harm.

In the real world, information absolutely can lead to harm, but it's still all in the response and how medicine and patients use information.

But as information gets cheaper and more common we can develop ways of dealing with it. If it was difficult and expensive to test for fever you'd see people in the medical profession warning against it because it could lead to overreaction.

user_7832
0 replies
23h19m

I get your point, however I think there are a few confounding things. For a lot of people, if you get a positive result from a test that a doctor brushes off that's not going to go well. I'm very much in favor of more testing personally, there are almost certainly folks who're on SSRIs who'd benefit more from Vit D/Mg supplementation for example.

Another thing I seem to remember in his video was that a tumor is not necessarily dangerous. Out of a hundred (say) tumors in a person's life, only maybe 5 are risky. But I'm paraphrasing this badly.

Edit: https://www.youtube.com/watch?v=7kQk9-KLPfU is one of the videos, however I think he's talked about this more (likely on instagram or another video too).

akira2501
2 replies
1d1h

If I'm not trained to correctly respond to the information then why should I believe that I'm going to?

mhb
1 replies
1d1h

You can learn?

akira2501
0 replies
1d

I can learn almost anything. So, I have to put values on what it is I'm learning, so I don't waste my time. My estimation is that learning how to interpret my health data so that I can spend a lot of time gathering and then continually interpreting that health data is not going to evince any additional value in my life.

queuebert
0 replies
1d

If you knew which signals were false positives, they'd be true negatives.

gtirloni
5 replies
1d1h

The unnecessary interventions are done by licensed doctors? Why?

tetramer
3 replies
1d

You don't know if it's a false positive or not until you do further interventions. Realizing it's unnecessary is only evident in hindsight.

E.g. CT scan shows an incidental, tiny lung nodule. You do a biopsy. Unfortunately, during the process of getting a biopsy, you develop a pneumothorax (an uncommon but well-known complication of a lung biopsy) and need a chest tube, hospitalization, etc. You get discharged and you're fine, but man, that wasn't fun. Biopsy comes back negative for cancer. Nodule goes away on its own with time.

Edit: that being said, I'm excited about OTC CGMs! But the "data" we have in medicine is not as accurate as other fields and always subject to false positives/negatives.

unlikelytomato
1 replies
20h36m

the gap between cgm and a biopsy from a CT scan is vast. CGM is not enough to trigger any such intervention. Unnecessary interventions are absolutely a concern. A CGM is about as controversial as someone taking their own heart rate to help them calm down from panic attacks. Minimally invasive and nobody would base a dramatic intervention on this data alone.

tetramer
0 replies
20h19m

Sure. As I stated in my original comment, I'm excited about CGMs being widely available. The example in my comment was very specifically answering "why do doctors perform unnecessary interventions?".

gtirloni
0 replies
9h56m

Agreed. Thanks for the perspective. Never considered downsides of such interventions (as I have been mostly a lab rat for doctors but never experienced things like that, but it's understandable).

queuebert
0 replies
1d

Doctors make mistakes. Procedures carry inherent risks, such as infection, allergies, blood clots, etc. Even driving to the doctor to discuss your blood glucose carries a risk of car accident. All of these are low probability events, but non-zero.

abletonlive
3 replies
1d

Dumb framework for dealing with incompetence.

"I'm so incompetent that more data is going to lead to worse outcomes! So let me stick my head in the sand and not measure!"

Imagine if any other profession operated under this framework:

"Ehhh, if we inspect too hard we might make a repair on this airplane that will cause further damage, lets just not do the inspection"

queuebert
2 replies
1d

Do you think tearing apart a working airplane and putting it back together in order to inspect it between every flight is a safe practice?

Did you see the 737 door plug accident?

You are missing part of the picture here. And that part is not that everyone else is dumb but you.

abletonlive
1 replies
23h14m

Do you think tearing apart a working airplane and putting it back together in order to inspect it between every flight is a safe practice?

Do you think this is....the same thing as a continuous glucose monitor?

queuebert
0 replies
22h59m

Mathematically, yes. The probabilities involved are different, however.

psychlops
0 replies
1d1h

What sort of risky false positives and interventions are you anticipating from knowing glucose levels?

Aurornis
3 replies
1d1h

Where is the harm in getting data on how your own body deals with glucose?

We have a relatively good indicator of long-term glucose levels: HbA1c blood testing. It's included in a lot of physicals now because it's relatively cheap. It's not 100% sensitive to every possible condition, but it's quite good as a screening mechanism for the general population.

CGMs will often give an "estimated HbA1c" value based on statistics from the collected data.

The challenge with CGMs is that it can he harder to know what's "normal" or not than you might think. There are a lot of stories of people becoming unnecessarily worried about occasional spikes or dips that are virtually inconsequential in the grand scheme of things.

crimsontech
2 replies
23h27m

At the age of 45 I had never had an HbA1c test. I found out I had T2 diabetes from getting a CGM as part of a health study I applied for, and seeing my blood glucose was at 22mmol (it should be under 10). I ordered a finger prick test kit from Amazon assuming the GCM was faulty but it wasn’t. After this I went to the doctors who confirmed with an HbA1c and put me on Metformin.

It certainly should be part of routine checkups in my opinion, but I had never had more than blood pressure check and a weigh in from my doctor.

bialpio
0 replies
19h1m

Where are you based? I have it tested annually, but only after moving to USA (from Poland). I don't remember if I had such a test done earlier - I think I might have had it done as a part of screening for whether I'd be allowed to go scuba-diving or something else sports-related.

Aurornis
0 replies
4h51m

HbA1C has been checked by all of my primary care providers across several locations in the US.

I also had an insurance provider who gave us a cash bonus if we had it tested (they paid) every year for a while.

It’s surprising that some doctors aren’t checking it still.

rockooooo
0 replies
1d1h

There are downsides to over-medicating, even if your personal budget for health is ~unlimited. Nobody wants to be a false positive.

akira2501
0 replies
1d1h

Where is the harm in getting data on how your own body deals with glucose?

That's not what you're actually measuring though. You're just measuring instantaneous blood sugar levels.

You're hoping that your process for correlating this data with other events and trends in your life is accurate and useful. Unless you're planning on bringing a lot of documentation and other data recording to pair with this, it's not likely this single data point is going to beneficially change outcomes for you.

happytiger
23 replies
1d1h

That’s some sage advice.

People are often surprised when I tell them about the insane levels of pre-diabetes in the US:

The National Center for Chronic Disease Prevention and Health Promotion notes that approximately 96 million U.S. adults aged 18 years and older (38% of the adult population) have prediabetes, and nearly 80% of them are unaware that they have it.

It’s honestly insane to continue a way of life that’s doing this to the majority of the population.

https://www.uspharmacist.com/article/prediabetes-trends-amon....

narrator
22 replies
1d1h

The other insane thing is studies have shown that type 2 diabetes can be reversed by fasting. Fasting is problematic to the medical industry because it is zero cost.

"Some studies found that patients were able to reverse their need for insulin therapy during therapeutic intermittent fasting protocols with supervision by their physician."

https://clindiabetesendo.biomedcentral.com/articles/10.1186/...

Aurornis
14 replies
1d1h

Fasting is problematic to the medical industry because it is zero cost.

No, fasting is problematic because people don't like it.

Health conscious people don't understand how much resistance the average patient has to advice about lifestyle modifications, or how difficult it is to get patients to adhere to recommended lifestyle changes.

A good example is sleep apnea and CPAP machines: In theory, a CPAP machine should provide life-changing improvements in sleep quality and daytime energy for someone with sleep apnea, yet patient adherence rates are shockingly low (even when covered by insurance). Many patients are simply annoyed by the machines and give up on it.

That's not to mention the fact that weight loss is extremely effective in many (though not all) sleep apnea situations, but it's rare that patients will actually follow through with that.

psychlops
6 replies
1d1h

It's also rare for a doctor to tell a person they are too fat and to lose weight. The assumption (and most cost effective solution) is that patients just want a prescription for something and be sent on their way.

US healthcare is crisis focused, not health focused.

TeaDrunk
3 replies
23h57m

It's also rare for a doctor to tell a person they are too fat and to lose weight.

Genuinely curious... have you ever been an obese person? Every fat person I've known have told me they're constantly shamed about being fat in medical settings, some to the point where they actively avoid going to a doctor anymore because they've given up on anything beyond being told they're fat.

porkbeer
1 replies
16h44m

It its a complicating factor in almost every ailment known to humankind. A doctor would be negligent not to address it. There is no healthy level of obesity.

TeaDrunk
0 replies
16h35m

So... you get my confusion and skepticism at this claim that it is "rare" for doctors to bring up obesity to an obese patient!

psychlops
0 replies
7h35m

I'd say I'm obese, and never heard a word about it. Even through covid. I have a friend who is a doctor who has been brutally honest with me (it's appreciated), but even though I've gone to many paid doctors in the northeast US, not a peep.

I don't want to confuse my experience with actual data. Also, I don't think it's shaming if it's a health issue and obesity should be recognized as such.

metabagel
1 replies
22h33m

It's also rare for a doctor to tell a person they are too fat and to lose weight.

I don't think this is true. Doctors do tell patients if they are overweight, and they do encourage them to make lifestyle changes including losing weight.

psychlops
0 replies
7h25m

Okay, that's fair, I didn't provide data so you responded in kind. So I went to find a study:

"Fewer than one of five overweight patients and slightly over half of obese patients reported being told they were overweight by their provider."

So "rare" is the wrong word.

https://www.commonwealthfund.org/publications/journal-articl...

watwut
3 replies
23h46m

Disordered eating is more dangerous then obesity.

slily
1 replies
12h46m

I doubt that's true unless the degree is extreme. Humans evolved with "disordered eating" and fasting is well-researched.

watwut
0 replies
11h50m

Humans evolved with a lot of behaviors that is or was not healthy. Evolution requires you to have offspring and have them alive until having own offsprings.

porkbeer
0 replies
16h43m

Both are worse than eating right. It's not a binary.

int_19h
2 replies
17h10m

Speaking as someone who has spent several months trying to adjust to a CPAP machine before finally giving up, it's not because it's annoying, it's because I literally can't sleep with the damn thing strapped onto my face. I'm well aware of the benefits, and I would love it if I could have them... but between sleep apnea and no sleep at all, the choice is obvious.

binoct
1 replies
13h10m

Everyone has a unique situation, but wanted to share my experience because improving apnea can have such a huge impact. I have a relatively mild case, so CPAP was borderline but I tried it. Like you spent 4 months and never got past 3 hours in one night, even trying several masks. Gave up for a year, worked on sleep hygiene in general and tried again. After about 2 weeks of a new mask and adjusting settings slept through the night. 5 years on I still wish I didn’t need it, but the improved quality of life means I basically never go to sleep without it. Can’t imagine how big a deal it is to someone with severe apnea.

You don’t need to completely throw in the towel if you don’t want to. Take breaks, try different masks as much as you can, get your dr to help adjust pressures. At least for some of us it does eventually click.

Good luck!

int_19h
0 replies
2h41m

I have a friend who got a CPAP and was happily sleeping with it on the first day, 5 minutes in. I'm very envious, but... I've already tried several different masks, went to the supplier to have them adjust that stuff to fit me etc.

At the end of the day, we are all different, and the threshold for what physical sensations a person can tolerate is highly variable. Everyone understands that about pain (I hope!), but this goes just as much for all these other things that are not necessarily painful as such, but are still physical.

staypegged
3 replies
1d

Fasting is problematic to the medical industry because it is zero cost.

Is this just an American thing? Every GP I've ever seen has asked me about my diet and exercise despite me being in the healthy BMI range.

epistasis
0 replies
1d

I don't think that fasting is problematic to the medical industry in the US. And if it is, it's not because it's zero cost. Doctors love zero cost interventions. The real challenge is just the standard medical challenge: 1) educating doctors as new evidence comes in, 2) doctors educating patients, and 3) patients complying with the intervention.

NegativeK
0 replies
4h29m

It's a pessimism thing.

I've had doctors (in America) tell me to not worry about medical issues and others recommend a battery of tests to look for correlated but uncommon issues. My current GP recommends basic, palatable approaches to diet and exercise that have nothing to do with giving them money (and, presumably, reduce my medical costs with them down the road.)

I've also had doctors suggest that I get an issue reclassified so they could do surgery. That could be viewed as them wanting money, but I view it as them seeing a problem that can be fixed by surgery because, as a surgeon, that's how they approach problems.

1234letshaveatw
0 replies
4h23m

Are you asking if your anecdotal evidence is sufficient to make an inference for all of Europe and the US?

graeme
1 replies
23h49m

to be clear this isn't reversing T2 diabetes. Rather, it allows you to manage it. But the physical damage causing T2 diabetes generally remains

yurishimo
0 replies
8h43m

The American diabetes association admitted last year that T2 can be "reversed" with the caveat that you mentioned about existing damage. However, to actually damage things to a level where they are noticeable takes years and years. If you catch it early, T2 is entirely "reversible".

nradov
0 replies
23h52m

Other studies have shown that type-2 diabetes can also be put into remission for many patients with nutritional ketosis. So, there are potentially multiple approaches to try.

https://www.virtahealth.com/research

znpy
3 replies
1d1h

I'd really love to be able to do that (experimenting) but i'm in the EU and haven't looked at the possibilities yet (i'm not diabetic).

However i recently saw a video of a woman that carried a glucose monitor (even if she didn't need one) as part of a study (she volunteered) and was able to correlate her mood and her weight take/loss with sugar intake.

I'm very curious about this. I've started a diet recently and after quitting many sources of sugar completely I'm very surprised how long i can go without eating and how little calories per day i can consume (well, as long as i have fat to burn at least).

If anybody wants to chime in and suggest a glucose monitor that i can get without prescription in EU (Italy) and from which i can pull off data, please do.

dhoe
2 replies
16h31m

I'm in the Netherlands and just bought a Freestyle Libre 3 from https://www.dia-centrum.nl/. It didn't require a prescription and was easy to set up and you can get the data out of Freestyle's website, as a CSV download if I remember correctly.

I had a doctor comment that he'd never seen anybody wearing one just out of interest, and he was slightly condescending about it.

ps2fats
1 replies
13h27m

Perfect, I'm also in the NL and was hoping someone would have more information. I totally believe the GP being condescending about it, they are trained as gatekeepers to medical care to reduce costs to the system (wife is a doctor). It is also unimaginable to them, for whatever reason, that people would pay for things out of pocket.

dhoe
0 replies
12h22m

Haha, yeah, don't get me started. My other recommendations along these lines for people who don't want to argue with their GP about which blood tests "make sense" is https://onedayclinic.nl/. Their pricing is somewhat confusing but you can just email them everything you'd like to measure and they'll make you a (reasonable) offer.

sdo72
2 replies
1d1h

I think I would recommend the opposite unless you are diabetic or pre-diabetic. Using this may make people think eating high GI food causes diabetes.

epistasis
1 replies
1d

Prevention of diabetes or even of pre-diabetes is well worth the experiment. At least for folks in the US, where metabolic syndrome is hanging over the head of a huuuuuge percentage of the population.

Hiding information from people because they might misinterpret it is not a successful medical strategy, the better strategy is to educate, see if the information will be welcome, then provide the information in the context of what it means.

I wasn't technically pre-diabetic, but did have a few higher-than-expected resting glucose blood tests, and the CGM showed me that I'm actually really close to pre-diabetes.

That was the kick I needed to clean up my diet (specifically eat less), exercise 5-7 days of the week, and I'm feeling better than ever.

Anecdata, of course, but there is no single intervention that has been discovered to improve people's weight and metabolic problems in the US (except perhaps the new GLP-1 inhibitors). Adding a CGM, at least for people interested in it, can be very effective, and we should use all the tools we have to improve the population's health.

sdo72
0 replies
1d

I think your approach is that giving more data to individuals so that they can be informed and make better decision about life choices. However, if we look at reality, the data is already there, without experimenting we can already get a ton of data. Then the question is have people made better decisions about their life choices. I think the answer is No.

And thus I doubt very much that with this device or devices like this, the diabetic population will be reduced. In fact, I believe it to be the opposite.

mikenew
2 replies
1d

Can you share a little about the "additional labs" you did?

I wore a CGM for about a month. Also found that my glucose numbers were not nearly as good as I would have expected, especially considering that I'm quite active and not overweight. But it's the "what next" that I'm stuck on.

smallerfish
1 replies
23h2m

Check out Peter Attila's book. He has a couple chapters on metabolic syndrome that should be helpful.

mikenew
0 replies
21h49m

I've read Outlive (and am a big fan of Peter Attia in general), but there's really not much there besides "exercise more, eat better".

I was on strict keto for a year, with daily blood tests to monitor ketone levels. My fasting glucose would still be above 100 often enough. Even a moderately sized carb-heavy meal can send my BG above 200 (even after being off of keto for a few months).

Maybe if I paid the $2500 for his "Early" program that details all the labs he does I might get some insight, but that is clearly priced for someone outside my tax bracket.

epistasis
2 replies
1d1h

Agreed, this is one of the better things I have done to take control of my own health!

It was very very surprising which foods, and quantities of foods, caused huge spikes.

However, this stuff is difficult to interpret. What should be the goal number for managing glucose spikes? What's good, what's bad? Ultimately there's a lot of judgement calls, just as there is with any health or fitness goal.

I learned a lot from Peter Attia's podcasts, but that required hours of listening.

My doctor offered to review my data with me, which was amazing. But many people's primary care docs may not have the experience or time.

anonfornoreason
1 replies
1d1h

+1 +1 +1 to Peter Attia, huge amounts of great content. My philosophy is that if there's any single topic where I should be spending five hours a month researching, it's personal health.

As far as spikes are concerned, I convinced my wife and my dad to both try out the same CGM. Neither of them really ever had any spikes of significance (maybe up to 130's), even when eating cake, etc. Obviously it varies from person to person, but the fact I would spike easily above 140 with boring foods (steel cut oats with no sweetener as an example) said to me something was wrong. My daily averages hovering around 100 to 105 were not in the pre-diabetes level but were close to it, even when eating minimal carbs and being extremely fit with a natural healthy diet. Also most of what you read out there with CGMs is related to people who actually have diabetes.

Finally, there's no one really to talk to about this stuff. You can eclipse your doctor's knowledge on the topic with about 5-10 hours of research. You can go get a broad set of labs and be right at the edge of the reference range on something (which is, depending on the lab, just a range of the general population, not a healthy range) and your doctor will shrug it off. The system is setup so that as long as you are in a sort of average, even with that average being pretty bad (half of the country is fat and pre-diabetic), the standard of care is to ignore it until you fall off the end. The line between hypochondria and being on top of your health is pretty thin, and most doctors will consider you a hypochondriac if you research and come ready to talk about the topic with any level of knowledge.

Projectiboga
0 replies
23h0m

Try melatonin it makes what insulin you have go farther. Type 2 diabetes is caused by excess inflammation.

pastor_bob
1 replies
1d1h

What are 'treatable' causes other than food intake?

anonfornoreason
0 replies
1d1h

One example is an iron overload disorder. Excess iron accumulates in various organs including your pancreas, liver, and pituitary gland. Catch it early and you can avoid liver cirrhosis, busted pituitary function, poor pancreatic function, heart issues, dementia, etc. Wait too long and you are on the transplant list.

Aurornis
1 replies
1d1h

Read up on what's normal, though.

I tried a CGM twice. I triggered the hypoglycemia (blood sugar too low) alarm multiple times, but felt completely fine.

After some research I discovered it's actually not uncommon for healthy people to have occasional dips below the preset hypoglycemia threshold, but as long as you're not having symptoms then there's no cause for concern.

I also talked to a doctor who complained that she had multiple patients showing up with concerns about their glucose numbers for various reasons after trialing CGMs, but they had similar spurious and unimportant problems (brief excursions out of range, etc.).

So if you're going to experiment, at least familiarize yourself with what's truly problematic. It's easy to misinterpret the data if you don't know what it means.

dreewf
0 replies
22h22m

Freestyle libre has a lot of hypoclyemia events due to pressure on the sensor. If you roll over at night, or lean on the sensor it reads way too low. It’s very annoying since you can’t disable the alarm, I have to turn off the Bluetooth at night. Similarly when you go into very cold water it will read lower incorrectly.

simple10
0 replies
1d1h

Experimenting with GCMs is by far the most useful and fun biohacks I've tried. I was part of the early beta for Levels Health.

Even if you don't suspect underlying health issues, the data provided for health optimization and gamification is worth it.

I used the GCM for 4 weeks and mostly tested how my body responds to various types of foods and meal timing. I also used an Oura ring to track sleep.

Main lessons learned: fat loading in the morning with a bulletproof (ghee) coffee didn't spike glucose and provided sustainable energy. Carbs for dinner helped with sleep but only if the meal was several hours before bed, allowing enough time for the double glucose spikes to return to baseline.

And Japanese sweet potatoes massively spike my glucose unless they're slightly undercooked. Cooking methods significantly changed how my body responded to the food.

coldcode
0 replies
1d1h

I found out I was barely in the diabetic range a couple of months ago; hopefully, with diet changes and Metformin, I will see my A1C at a better number in a month or so. Otherwise, I would like to try a CGM to see what I am missing.

RecycledEle
0 replies
1d1h

I assume you mean you experimented with another CGM, since this one is not on the market yet.

NotGMan
0 replies
1d1h

I second, I wore it multiple times as a non-diabetic and it was very enlightening.

mangoman
57 replies
1d

I recently had an unusual health event that resulted in me passing out. My wife, who is a physician, thought it might be hypoglycemia, since i'm at high risk for diabetes. She found a super friendly endocrinologist who put me on a CGM for two weeks. I never hit the hypoglycemia range during those two weeks, so it didn't really explain what my issue... but honestly the data was SUPER interesting. Just observing the various spikes made me make healthier choices, or noticing when I was feeling extra tired and seeing if that correlated to not having eaten for little while, or eating something sugary before.

It's sort of like tracking your steps when you first get a smart watch. It may not have been the reason you got the device, but seeing the data, people are encouraged to act on it, even if you don't have an acute issue. since I didn't have a prescription, I couldn't get one here (didn't want to go through some sketch online site). I tried to get one from my family in India, but the prices were really high and they couldn't get the fancier one that tracks straight to your phone, so I didn't get one.

I think this could be a god send for preventing pre-diabetic people who would take preventative steps if it weren't such a pain in the ass to measure consistently.

bakedoatmeal
10 replies
18h26m

What is the connection between being at risk of diabetes and hypoglycemia? Wouldn’t a pre-diabetic be very protected from hypoglycemia?

ijustlovemath
5 replies
18h15m

No, diabetes is fundamentally a lack of ability to control your blood sugar. This means you get lots of highs but also lots of lows. It's a common misconception that diabetes just means your blood sugar is always high; rather, your sugar is high because your body no longer controls it actively.

beanjuiceII
1 replies
16h50m

You don't get lows from diabetes

pgporada
0 replies
1h7m

Are you being pedantic on purpose?

bakedoatmeal
1 replies
17h59m

Diabetes mellitus is an insulin problem- either a lack of insulin (Type 1) or insufficient response to insulin (Type 2). Insulin is responsible for lowering blood glucose. The hormones responsible for raising blood glucose (cortisol, IGF-1, glucagon, epinephrine) still function normally.

My understanding was hypoglycemia only occurs in diabetes in the presence of medications used to lower blood glucose (insulin formulations, sulfonylureas, etc.) and not because of diabetes itself, which when untreated invariably leads to hyperglycemia.

TylerE
0 replies
12h23m

It’s not either or, either. Some really unlucky folks end up with a hybrid and have both problems… they don’t produce enough insulin or react well to what they do.

cstrahan
0 replies
17h55m

I'm pretty certain you're mistaken here. Diabetes is specifically characterized by elevated blood glucose, either due to pancreas not producing enough insulin or your body becoming descensitized to insulin.

You will find that diabetics often do have low blood sugar, but that's because they overestimate how much insulin they need to inect, causing their blood sugar to go too low. The hypoglycemia in this scenario is not caused by diabetes, but rather a dangerous side effect of the treatment.

OP doesn't have diabetes, and (unless he's abusing insulin for body building purposes) isn't taking insulin. His postprandial hypoglycemia is likely a benign case of "reactive hypoglycemia" (https://www.mayoclinic.org/diseases-conditions/diabetes/expe...).

veryfancy
2 replies
15h56m

Wondered this too. Diabetics are at risk for hypoglycemia because of the insulin they take, not the diabetes itself. Maybe metformin for a prediabetic could have this effect?

TylerE
1 replies
12h24m

Nah, even as a full blown diabetic metformin doesn’t drive you low. It basically just makes the same amount of (naturally produced) insulin do more, essentially.

pgporada
0 replies
1h5m

even as a full blown type 2 diabetic*

code_duck
0 replies
13h9m

There is something called reactive hypoglycemia.

https://en.wikipedia.org/wiki/Reactive_hypoglycemia

It can occur for various reasons. Personally, I was developing adult onset type 1 (LADA) for a couple of years before I was diagnosed and I had all sorts of effects. While it was of course mainly effects of chronic hyperglycemia and shortage of insulin, I also had some episodes of hypoglycemia. Now that I’m on insulin, I’m very familiar with hypoglycemia resulting from an imbalance of exogenous insulin and carbohydrates. However, I looked back and realized this happened to me a few times before I was on insulin. I recall waking up a few times at night, sweating and shaking, and having a strong urge to consume food. I’d drink some juice or eat chips, feel better in 20-30 minutes and go back to sleep. This occurred after drinking alcohol, which makes sense as alcohol intensifies the effect of insulin and also prevents your body from releasing chemicals which raise your blood glucose level. I didn’t think much about it at the time but now I can see it was related to T1 onset.

My understanding is that essentially the body’s systems which regulate blood glucose are disrupted. This happens a with type 1 in general - not only problems with the system that produces and releases insulin to lower blood glucose by allowing it into cells, but also the part that does the opposite and release glucose to raise blood glucose levels. Sometimes the glucose-raising system doesn’t work at all while other times it’s inappropriately in overdrive. The same is true for the insulin releasing/glucose lowering system as it fails.

necovek
7 replies
17h5m

I personally wouldn't mind having the data if a need comes up, but this is simply overtracking for no particular purpose.

Basically, our bodies go through much "turmoil" over the course of any day, and watching over one too many parameters is like getting hooked to TV or a video game.

Generally, medical science can mostly tell you what averages or most common patterns are, so if you do not line up with them and don't understand this, you can get overstressed.

So unless you are really someone who can objectively consider your readings combined with effects you might be seeing, I'd say don't do it.

necovek
2 replies
16h6m

And reading further, there is evidence of people getting worked up about what are not problematic readings in this very thread.

lynx23
1 replies
15h36m

Watching a heartrate monitor sometimes has the reserve-progress-bar effect. You know the deal. You realize the pump is on a hightened frequency, so you see what your smart watch says. And the more you watch it, the more anxious you get, so the rate stays more or less high.

TylerE
2 replies
12h21m

More importantly for life style monitoring A1C is the more important number anyway, and doesn’t require wearing anything, just a simple blood test. It’s basically a 3 month moving average.

RHSeeger
1 replies
6h40m

At least for a diabetic, A1C is less looked at nowadays. With CGMs, we can lookt to see our time-in-range, highs, lows, and patterns. It's... amazing.

Plus, you can see just how much different types of foods directly impact your blood sugar. For example, white rice and pizza are crazy for raising glucose levels. I knew about pizza, but I had no idea that white rice what quite _that_ bad.

salad-tycoon
0 replies
3h44m

Doesn’t have to be white. Rice is how I helped screen my wife for gestational diabetes instead of that awful nukacola sugar slam they make pregnant women do and then check sugars at predetermined times when challenged with 50g rice or 50g sugar.

Anyways, yeah rice is basically the insulin dietary equivalent of sugar.

whatshisface
0 replies
2h20m

Getting hooked on smooth blood sugar changes sounds like a possible counterweight to what our brains are designed to get hooked on... Oreos.

lr4444lr
7 replies
23h12m

What kinds of food intake/non-intake habits aside from the obvious culprits surprised you?

rodly
6 replies
20h40m

Long-term they will likely make no changes because human desire, habits and behaviors are rarely unknown to us.

The parent comment mentioned feeling tired after consuming something with a lot of sugar, was that really a mystery prior to using CGM? I doubt it.

Sure it's interesting to correlate to your perceived wellness (or lack thereof) with a wearable spitting out data but after the novelty of this discovery wears off my guess is that people will simply stop caring to check what they already know to be the case.

sxg
0 replies
20h33m

The parent comment mentioned feeling tired after consuming something with a lot of sugar, was that really a mystery prior to using CGM? I doubt it.

They may not have known just how sugary that item was since most people don't bother to calculate the sugar content of everything they consume, but the CGM puts a number on it. That experience could be enough to change the OPs behavior. I agree that most people may not care to make behavioral changes in response to more data, but there are definitely other people who will.

o_____________o
0 replies
20h19m

It's more than intake. It's food order, stress, sleep, context, and so on. Did you eat enough fiber, did you add more fat this time, did you drink the night before? Did you walk afterwards? Unless your life is extremely regimented and uniform, they provide a ton of data.

jxramos
0 replies
19h34m

there is something powerful about the objective outside-of-self confirmation of something because it eliminates the doubt that can be casted as it all being in ones head. External confirmation is enlightening and motivating.

jeremiahbuckley
0 replies
18h12m

My view: I’m busy, I have a lot of things I’m trying to figure out. For example, All of my free time should be spent getting better at AI programming. Seemingly infinite horizon.

I could carefully track a half dozen signals to correlate consumption to effect, but if the effect is “I’m tired and don’t have much willpower”, that’s hard to remember to track. I just haven’t built up that habit; heck I’m having a hard time keeping up the habit of light exercise.

I have a cousin who was diagnosed with some stage of diabetes; got a continuous blood sugar monitor; ended up losing a ton of weight. I’m definitely in the market for this—something to make it easier for me. It’s undoubtedly healthier for me than mainlining wygovey, which is another option on the table.

dog_boxer72
0 replies
19h41m

Is it really such a stretch to imagine that maybe some people really don’t correlate those things? People aren’t research papers, we have multiple cognitive distortions working all the time obfusticating the truth, but tech like this can help bypass them

dleink
0 replies
20h15m

Long-term they will likely make no changes because human desire, habits and behaviors are rarely unknown to us.

It seems like this thinking leads to desires, habits and behaviors remaining a mystery to us.

cleandreams
5 replies
15h14m

I am prediabetic and I have one. It's partly covered by insurance. By the metrics my estimated average glucose has gone down from 129 to 98 or so (normal). I haven't had my HbA1c in awhile.

I think they are amazing. It's been SO HELPFUL. However I don't think it makes sense for normal people. I am on a reddit group for prediabetes and it's not unusual that people who are underweight (anorexic?) and have completely normal metrics come in and post in an utterly freaked out state. These are people who are somewhat compulsive and anxious. I think that if you are normal for blood glucose having access to all this data can make you compulsive and anxious.

However, for me as a prediabetic, it is really useful. It tells you what’s going on with your blood sugar in real time with no ideology. In the beginning I was spiking from things that a nutritionist would say was OK. I found whole grains didn’t work for me. I was shocked at how much I spiked from oatmeal. What causes blood glucose spikes does not map directly to number of carbs and also every body is different.

After 6 mo of lowered carbs, weight training, and getting down to normal BMI, I can now eat SMALL portions of things like brown rice. My health has improved. It's great. IMHO all prediabetics and diabetics should have one, covered by insurance. It would really improve health and reduce complications.

michaelcampbell
2 replies
5h34m

I was shocked at how much I spiked from oatmeal.

Was it oatmeal, or what you ate oatmeal with (milk, sweetener, etc), or do you know?

pwthornton
0 replies
1h49m

The people at Levels, who do continuous glucose monitoring, say that oatmeal is one of the worst offenders.

You really need to spike your oatmeal with fats, protein, and fiber.

I regularly eat steel-cut oats for breakfast. My go-to is steel-cut oats, two tablespoons of Chia seeds mixed in (tons of fat and fiber), and a serving of mixed nuts and berries on top. On the side, I eat four scoops of powdered peanut butter mixed with water. This version of peanut butter is much higher in protein and much lower in fat and calories than normal peanut butter.

Doing all of this can keep the spikes to a reasonable amount (I also eat the powdered peanut butter first). Any kind of oatmeal by itself is bad. Instant oatmeal is worse. Instant oatmeal with all that sugar and stuff thrown in is terrible.

I suspect if you made your oatmeal with milk instead of water, it would help a lot, but I can't do this from being lactose intolerant.

eternauta3k
0 replies
4h11m

Also, instant oatmeal / rolled oats / steel cut oats / the whole dang oat?

lawlessone
0 replies
5h17m

However I don't think it makes sense for normal people.

I agree , but if it's anything like gluten free foods, having more people buying that don't need to, might push prices down for you.

TylerE
0 replies
12h26m

What’s also surprising is what doesn’t. I’ve found for instance, that potatoes, even French fries, don’t do a whole lot to mine.

cheriot
5 replies
20h56m

Thanks for confirming. Normal feedback on health habits is delayed by months/years and hard to trace back to specific actions so your story makes a lot of sense.

I might have to get over my dislike of needles :|

mikenew
4 replies
20h29m

It's more akin to a finger prick than a needle. Might still be a bit psychologically challenging but I've done it and it's really not bad at all.

jorvi
3 replies
18h49m

I'm not even diabetic but they always pre-check your blood during blood / plasma donating. I would say it doesn't even register as a pinprick and feels more like the percussive slap of a tiny elastic band.

mikepurvis
2 replies
18h3m

Ha, I would say quite the opposite, that the finger prick is my least favourite part of giving blood— it's ironic that taking a few drops could be that much worse than the big honking needle which draws an entire pint, but I guess fingertips just have a lot of nerve endings.

RHSeeger
0 replies
17h39m

As a diabetic, I've always found that the finger prick for testing my blood hurt more than the insulin needles.

0_____0
0 replies
16h36m

Not sure if the blood center people have a protocol for this but in athletic labs you can sample from the earlobe to take blood lactate readings

melagonster
4 replies
12h55m

Excuse me, this is stupid question. but can't you buy Freestyle Libre?

TylerE
3 replies
12h26m

Yes, but need a prescription.

melagonster
2 replies
10h2m

wow... I am sorry. in my country the condition is reversed. it cheaper than prescription version, so I ask it. good luck bro.

hackernews1134
1 replies
9h24m

Which county is that please? If you don’t mind sharing.

yurishimo
0 replies
8h52m

You can buy them OTC in most of western Europe.

aledalgrande
4 replies
14h50m

I actually just got one of these CGMs after listening to Peter Attia's (audio)book Outlive and started monitoring my glucose and experimenting with meals and exercise to see what effects they have. Apart from the weirdness of having something attached to your skin, it's like having another watch and you won't notice after a while. It's pretty cool and a lot more people than just diabetics would benefit from this knowledge.

Like I just learned for example about resistant starches, of which one is cooled potatoes: I ate the exact same dish but the first time, right after cooking, my levels shot up (not abnormally but you should ideally never have spikes, so your body doesn't have to keep pumping insulin), and then the second time, reheated, it was like I didn't eat anything. I was surprised so I researched and found https://www.webmd.com/diet/what-to-know-resistant-starches

Everyone is different so I definitely suggest to try them out for a month and see what gives you spikes in your diet. Then try to get rid of those spikes.

technological
2 replies
10h8m

can you post link to the device which you brought

mlrtime
0 replies
6h19m

Probably a Dexcom G6/G7?

aledalgrande
0 replies
5h40m

I'm using an Abbott Freestyle 2, but any of the available big brands that have an app would work.

droopyEyelids
0 replies
1h14m

You got me real curious about why this is.

I know there are waxy and starchy potatoes that have higher rations of amylopectin vs amylose starch respectively.

One interesting thing is that if you continuously mix an amylopectin potato, it turns into a gooey, ropey substance that we don't use much in western cooking but is how some Chinese mashed potatoes are supposed to be prepared. I wonder if that transformation affects the resistance of the starch.

I also wonder what exactly is making the cooled potato tougher to digest.

temp_praneshp
3 replies
22h16m

The ones on diabetic warehouse don't work well enough (https://www.diabeticwarehouse.org/collections/continuous-glu...? Or is that site sketch for you? I think you can just get one if you are willing to burn $500 (not cheap, but only in the price range of a higher-end smartwatch)

vlabakje90
2 replies
22h9m

Keep in mind that a single sensor will work for only a week or two, depending on the type. So it's not exactly right to compare the price to a smartwatch.

temp_praneshp
1 replies
17h21m

Ah okay, thanks for telling me that; I thought you keep recharging the battery every week from the description.

pwthornton
0 replies
1h47m

No. They are single-use, and it embeds into your skin with a probe.

dkarras
2 replies
19h20m

how is having low blood sugar a sign of pre-diabetes? I get frequent bouts of hypoglycemia.

murukesh_s
0 replies
18h42m

At some point a person's body may become resistant to insulin and start to need more insulin to have normal functioning (pre-diabetes), sometimes this causes large variation in glucose levels, though not as drastic as taking a medication. Eventually your body would adapt to it when you reach the diabetes phase.

keymasta
0 replies
13h50m

It could be related but I also want to weigh in here and say this. Hypoglycemia can occur with no relation to the other side of diabetic symptoms, i.e, hyperglycemia. In other words there are people who suffer from hypoglycemia without ever getting high blood sugar, and so they are not "diabetic" which would mean you can have issues from both directions.

jxramos
0 replies
19h38m

definitely, catching the "quantified self" bug is a real thing!

coldpie
29 replies
1d2h

I'm T1D (insulin-dependent). I used a Dexcom for a couple years a while ago, back around the G3 through G5 era or so. I ended up stopping using it because my diabetes is very well managed, and I found it didn't make a huge difference to my management. With my insurance, each new sensor every week cost about $50, and would fail in various annoying ways: sometimes it would just stop working in the middle of the week, or not work at all from the start, or disconnect randomly for a few hours. Each sensor also used a ludicrous amount of plastic for its applicator, like a tennis-ball-sized hunk of hard plastic, that you just chucked in the trash, every week. Maybe things have improved, but it was a bad combo of unreliable and expensive so I just quit using it and went back to finger pokes.

If it were like $5 per week, I might put up with it. Maybe this over-the-counter model will be affordable. We'll see, I guess.

mlsu
8 replies
1d2h

Dexcom and Freestyle both have options (G7, FSL2) that have a much narrower form factor than the old sensors. They end up being far more reliable, because the sensor doesn't dislodge. The new Dexcom sensors are more accurate. Less drift and no calibration.

Out of pocket cost is obviously your own situation but I think anyone with T1 should look at them. For me they are life changing, even moreso if you have a pump that can deliver based on CGM readings.

Plastic waste situation is still bad.

user_7832
3 replies
1d

The new Dexcom sensors are more accurate. Less drift and no calibration.

As someone using a freestyle libre who's never calibrated, how often do you need to calibrate it? Reason for asking is that I'm likely to switch to the g6 if I go with the TSlim X2 for looping. TIA!

mlsu
2 replies
23h52m

No calibration is required for Dex G6/G7. I think you can optionally calibrate the G6 but I never have nor have I ever had to.

I am going to be biased: I both work on and use the t:slim X2. It is well worth it, especially if covered by your insurance. CIQ took me from ~70 to 85%, sometimes 90% time in range; my understanding is that it's the best closed loop algorithm out there currently.

Regardless of which pump you end up on, having a closed loop system will significantly improve your control and helps you get that extra little push from the 7's into the 6's a1c range, which I'm sure you know is tricky to do manually without lows.

user_7832
1 replies
23h25m

Thanks! Hearing (I'm assuming) a fellow T1 using and working on a TSlim is quite a good recommendation haha.

It's good to hear that calibration isn't really required.

My "concern" (or rather, apprehension) with the TSlim/G6 setup (which fortunately should be fully covered by Dutch insurance) is that I'm aware I can do a DIY loop using the omnipod dash and with a libre/g6 (using a 3rd party app like diabox & nightscout if necessary). From what I've heard TSlim does seem to be the best "official"/FDA approved loop; however AndroidAPS looks very powerful and probably has much finer tunings possible.

However my diabetic nurse is strongly against the Dash/DIY setup, which is understandable (she isn't familiar with it and can't guide me, I'm also close to the 150u/3day limit, and it's my first time with a pump.)

For what it's worth an A1C of even 8 would unfortunately be an improvement where I am :') so I'd rather be sure of reaching say 7 rather than try aggressively for something like 6.3 (which I had achieved in a distant era...). I think I'll try the 1 year trial option if I can, the thought of locking in a 4 year period feels quite long.

If you're familiar with them, what are your opinions on diy loop setups? Do you have any other suggestions for someone in my situation? Thanks a lot!

mlsu
0 replies
22h15m

I actually have tried the DIY loop with the older insecure Medtronic pumps that could be controlled over radio. It was openAPS. I'm not sure if there are others or how they work.

It ended up being fairly inconvenient. My setup was a pi zero with a radio bonnet running on my desk; it would connect to the internet to pull CGM data, and deliver boluses accordingly.

I think the main issue was that I wasn't babysitting it enough to know if it was working or not. It was hard to see/understand bolus decisions it was making unless I checked iob, and it absolutely destroyed the battery life of my pump; I used a AAA once every couple days when I was near my desk, nevermind the battery on the rig (I had it plugged into the wall).

Overall, the system that you actually use the most, that is the most reliable, is the most effective system, even if it's a little bit suboptimal. In my case, CIQ is probably a bit less aggressive than the openAPS system; but importantly, it is truly "set and forget." I never have to worry if it's enabled or when, or how, it's just always working, 24/7. With a condition like ours, consistency is the best predictor of performance. That makes it the clear winner imho, unless you really like to tinker with things and you want to be very active with your loop.

The other thing is that the software (openAPS) was Javascript and Bash on a Linux system. Those architecture choices just make me nervous. Too many bad things that could happen. I'm not saying it's impossible for open source software to be reliable, certainly not, but the complexity of their system was just too large of a surface area to fully test. There are extremely significant cybersecurity risks using those older pumps also. It's basically root access to the bolus button.

coldpie
1 replies
1d2h

Glad to hear they're improving, though the waste situation is bizarre. I will probably go back on one at some point, I didn't hate it, just didn't feel it was worth the cost/benefit ratio. It didn't impact my A1c, I've always been in the low 6s, and I've only had two lows that I would consider significant in my 25 years with the disease. Benefit just wasn't there for the hassle and price.

mlsu
0 replies
1d

That is impressive control, especially with no CGM!

umvi
0 replies
23h12m

The new Dexcom sensors are more accurate. Less drift and no calibration.

I found the Dexcom G7 to be inaccurate by 10-20 mg/dL out of the box. I have LADA, and G7 initially was giving me a very rosy view of my blood glucose levels, until I started pessimistically calibrating it with a finger prick glucose monitor.

mjaniczek
0 replies
22h57m

life changing

Yeah, seeing ~300 datapoints a day instead of 4 while pricking your fingers is amazing QoL improvement. Dead serious.

bsder
5 replies
1d1h

Each sensor also used a ludicrous amount of plastic for its applicator, like a tennis-ball-sized hunk of hard plastic, that you just chucked in the trash, every week.

Erm, let's be a little defensible here.

These sensors have to be stored in sterile packaging--that means thick enough to be a barrier. That means it also has to hold the sensor in such a way that a palette can be gamma irradiated. It also needs to be resistant to drops, crushes, and other accidents.

The sensor has to not be harmful with organisms irrespective of the understanding of the person using it. Any change to that packaging has to be re-evaluated for effects on that sterilization.

And while I understand people having concerns, if the only reason we needed to use plastic was to treat folks with diabetes--I think the world would somehow manage.

coldpie
3 replies
1d1h

Eh, maybe, but the bulk of the applicator is just empty plastic molded to fit an adult's hand. I have to believe they could figure something less wasteful out (reusable applicator?) if they wanted or needed to. Regardless, it was just another downside for me weighed against the relatively few upsides that made me quit using it. It felt terrible to chuck all that in the trash, especially when I'd have to do it two days in a row because a sensor failed.

[1] https://fm.cnbc.com/applications/cnbc.com/resources/img/edit...

thecosas
2 replies
23h58m

T1D currently using G6 / Omnipod Dash / open source Loop app.

The worst is every 90 days when I get a new G6 transmitter. It comes in a box the size of Two video tapes stacked on top of each other. I've tried reaching out to my mail-order pharmacy about it since I know there are smaller versions of it (or used to be), but nothing yet.

From what I've seen, the packaging for Dexcom G7 and it's applicator seems much smaller than G6's.

Side note: That applicator for G4 instilled fear every time I had to use it and I was already 20 years into T1D by then. The spring loaded applicators in G6/G7 are a big improvement as far as end user experience IMO :-)

coldpie
1 replies
23h35m

Hahaha, the huge syringe thing? That was pretty wild! The spring ones felt like putting a needle to a balloon though, always made me tense when I was putting one on.

Yeah the Dexcom stuff always felt like they were going for super-premium Packaging Experience. But after the first couple weeks that wears thin, and now you've got all this crap to throw away. Like, guys, my pen needles come in a dense little cardboard box and it's totally fine. Chill out with the packaging.

thecosas
0 replies
23h1m

"Let me just hyperventilate really quick before I literally plunger this thing into my body" was always how it felt lol.

Agreed that it's gotten old, especially if I'm traveling somewhere. Needing to cart what you needed (plus backups of course) ends up taking up a surprising amount of space.

I will say that making the switch from a tubed pump (t:slim) to a tubeless (omnipod), it's drastically cut down on the waste for pump stuff at least.

innolitics
0 replies
21h23m

I work in the medical device space (mostly software as a medical device). I attended the AAMI Nexus conference two weeks ago and attended a talk about making devices more eco friendly. The tension between safety and sterilization and packaging was definitely brought up. It’s a hard balance to make. One example I thought was interesting was that the NIH did a study to see if it was necessary to swab people’s skin and use gloves before a shot. It turned out it wasn’t and it didn’t make a difference, so they stopped requiring the providers to swab people’s skin or wear gloves, thus saving an immense amount of waste when taken over all vaccine shots.

cadr
3 replies
1d

I just started with the G6 (still using it), and when I started I'd have that sometimes. Whatever they changed in the past year or so, it has gotten waaaaay better. (They would always replace them if they failed early, but was still a huge pain.) I'm exited to move to the G7 (mainly because of the shorter warmup time).

Also, pairing it with the Omnipod 5 is just next level. Closed loop. Never having to inject in public. No tubes.

lewismenelaws
2 replies
1d

I have the G7 and it's incredible. On a medtronic pump... wanting to switch asap

cadr
1 replies
1d

The omnipod isn't setup with the g6 yet. Can't wait.

T1DTech
0 replies
23h33m

I think you mean G7.

ng12
1 replies
20h24m

You went back to finger sticks? I am floored. Do you follow a strict low carb diet? How often are you exercising?

coldpie
0 replies
7h21m

Definitely not low carb, no. I have a bowl of oatmeal for breakfast 4-6 times a week :) My diet is pretty consistent though. I know how that oatmeal will respond to insulin 90% of the time, and the remaining 10% random quirks I can just deal with by feel & a finger prick to confirm. The thing I'm most strict about is I only allow myself to have about one "bad diabetes meal" per week. So that's like any restaurant food, or doughnuts, or pizza, or whatever. I mostly only eat home made meals, my wife & I both love to cook. But those aren't low carb, just whatever we feel like cooking that week.

I walk about a mile a day, to the bus & back for work and a bit for leisure and to get up from my desk. Otherwise I don't exercise.

eitally
1 replies
1d1h

fwiw, my wife uses Freestyle Libre 3 and the with-insurance cost every two weeks is about $40. Whenever she's had one fail (which seems to be about 1:10), Abbott has replaced it free of charge and sent a pre-paid label so she can return the failed device for QA review.

coldpie
0 replies
1d1h

Yeah, I feel like prices are on a downward trend the last couple years, which is great. For me personally, I try to spend absolutely as little time and effort as possible thinking about my diabetes. So having to call the manufacturer or fill out forms and receive a package (more waste) and ship a thing back (even more waste) is just too much time and effort for me to want to bother. I hope they keep improving, it's cool tech and I'd like to like it. Just not there yet.

agawish
1 replies
11h42m

I'm really intrigued by your statement that your diabetes is well managed, if I wake up in the wrong side of the bed, my insulin resistance change!

Wondering how you can maintain that, do you have a very rigid routine and meal plan?

I'm using Libre2 as part of my prescription and it has been working wonders by alerting early on before it is too low or too high to have enough time for a correction dose, or a small bite. The fact that you can see the trajectory of Glucose going up or down is by itself a reason to get.

coldpie
0 replies
8h34m

Hm, I'm not sure. I don't talk with other diabetics much so I guess I don't know what other's experiences are like. I go to sleep and wake up on the same schedule every day including weekends. My eating is not rigid, but does tend to be consistent just because my daily routine is consistent. I'm not "low carb" or anything, but I do follow a healthy-ish diet and avoid hyper sugary foods (soda, coffee milkshakes, sugary cereals) like the plague. Diabetes or not, no one should be eating that stuff :)

I do miss having the moment-to-moment trajectory information. Knowing whether I'm still going up 90 minutes after a meal was valuable. But I find I'm able to feel when I'm above 200 mg/dL, so can just correct by feel most of the time.

Etheryte
1 replies
1d2h

The plastic waste issue is one of the first things that usually comes up around this topic regardless of who you ask. It's such a shame because it's not like you have many options unless you're comfortable going without sensors.

berkes
0 replies
21h28m

All my diabetes stuff is free, in my country. But it must be shipped to my house in Quarterly deliveries.

Shipped in several boxes, each filled and wrapped. then the GCMs, strips, refills, pump connectors come in their own boxes. Some per ten, some single. Each sub-box has several booklets with instructions and safety guidelines. Each unit is individually wrapped in plastic, paper. All of them are single use. Even connectors and rods.

Our combined household has less waste than my insulin therapy produces. One single insulin therapy produces more plastic, paper and wrapping weight than what my wife and I produce together on everything else.

It's utterly insane.

micro_cam
0 replies
1d

The g7 is definitely a bit better on all counts except maybe bluetooth reliability. I use them with [open source closed loop](https://loopkit.github.io/loopdocs/) insulin pump software and it is pretty great.

Still a lot of plastic but the sensor comes in a smaller jar/applicator in a cardboard box and it pretty reliably lasts 10 days cutting down waste.

It sounds like this new sensor is just a g7 but with less stringent accuracy standards for non insulin users allowing it to last 15 days.

1123581321
0 replies
1d2h

I think your experience was unusual in that you had so many failures (hopefully you at least got your broken sensors replaced for free; both Dexcom and Libre do this) and that you are good at managing your diabetes without many measurements.

The out-of-pocket expense can certainly be rough; I use Libre right now because my Dexcom out-of-pocket would be similar to yours and Libre is a third.

I lend my CGM to people to who are possibly prediabetic. I'm very glad I can point them to an OTC solution now.

rkagerer
26 replies
1d2h

When your smartphone becomes a critical health device to support/treat a condition I wonder how that will impact case law around things like police confiscation.

saagarjha
14 replies
1d2h

What happens when an officer confiscates your glucose monitor today? I assume you die and they claim they did it for some valid reason or the other.

mft_
5 replies
1d2h

Type 1 diabetics have been managing their insulin for decades with occasional blood sugar testing - i.e. certainly not testing for every dose. They’d be fine to manage things for a period without a confiscated monitor.

user_7832
0 replies
23h57m

Type 1 diabetics have been managing their insulin for decades with occasional blood sugar testing - i.e. certainly not testing for every dose. They’d be fine to manage things for a period without a confiscated monitor.

This is similar to saying "X person can survive without y medicine which has only been around for 10 years". Or "people survived fine without seatbelts for so many years".

That's a classic survivorship bias, because a ton of diabetics didn't survive, who'd possibly have a much higher chance of surviving today with current tech. Heck, I personally know the brother of a late diabetic who would've been alive today if he had a phone connected to a CGM because of it's low glucose alarm function.

I understand HN is a place for discussion, but in potentially deadly situations like this, it's worth avoiding to make statements against medical care.

sunshinesnacks
0 replies
1d1h

They’d be fine…

But before long there will be diabetics that never really learned to do that because they never had to. Even people that have done that for decades still mess up dosing sometimes.

How likely is it that someone might die? I don’t know. But saying they will be fine might not be fair.

smt88
0 replies
1d1h

There are people who connect insulin pumps to their CGM. There will be situations where people can't quickly switch to manual BG management after setting up an automated solution.

justinclift
0 replies
1d1h

They’d be fine to manage things for a period without a confiscated monitor.

That could go very wrongly if they're already at the end of the safety period when they're grabbed by the cops.

bradleyy
0 replies
1d1h

Hi, Type 1 diabetic here.

I can fast for days, my blood sugar does not go down.

On my last 4 day fast, my blood sugar stayed within about 20Mg/Dl.

And no, I cannot manage without my medical devices. Or are you telling me that I should fast for the entirety of police custody?

bschne
3 replies
1d2h

Yes, but you can't easily use your non-smartphone glucose monitor as a communications device to manage a bunch of drug dealers which can't be confiscated because your life depends on it. That changes once it's your smartphone.

saagarjha
2 replies
1d2h

See, my point is that they’ll do it already when it’s not even reasonable to do so. So when they take your phone away, which can be done so more credibly, why would you expect more protections?

bschne
1 replies
1d2h

Do they? I'm not aware of cases (but generally not up to date on topics like this, genuinely curious)

pastage
0 replies
1d1h

Call it malice or ignorance, it is hard to tell. I have personally visited someone who did not get insulin for a whole night in jail, ended up with extremly high blood sugar (DKA) (s)he had to be hospitilized for three days. There were no penalties for the officers.

Basically someone with diabetes can seem to be a very unhealthy and drunk person, and people do not tend to take these people serisouly.

mlsu
1 replies
1d

Wow, that article is wild. For those who are not aware, ketoacidosis is when your body metabolizes fat for energy in the absence of insulin. This produces byproducts (keytone bodies) that raise the pH of the blood.

So, having ketoacidosis feels like having your blood turn to acid. Death from ketoacidosis is an excruciating death. Fermenting from the inside out as your heart pumps your increasingly acidic blood through your entire body. You're technically starving, so you're hungry, but at the same time your body is trying to expel glucose at all costs, so everything you look at makes you sick.

Extended periods of high blood glucose and lack of insulin especially is up there as one of the most uncomfortable things I've ever experienced personally. Just unimaginable cruelty.

thecosas
0 replies
23h51m

Can confirm, feels like crap.

smileysteve
0 replies
1d

They jail you, give you low quality food, and eventually the jailer may send a medical team to manage your type 2 diabetes -- most likely with a finger prick and test strip; and they'll give you dietary guidelines that the jail/prison food doesn't satisfy.

US version; (oh, and they'll charge you for the medical care)

uxamanda
5 replies
1d2h

Interesting, never thought about that. Also wonder what happens in Airplane mode / poor reception?

hammock
3 replies
1d2h

CGMs use bluetooth

justinclift
2 replies
1d1h

Bluetooth has a terrible reputation around reliability. :(

pastage
1 replies
1d1h

In the loop community (CGM+insuling pump) you usually have a list of phones that work well with Bluetooth. Yes that changes when the phones get new powersaving settings and driver updates, usually it works well on good phones.

justinclift
0 replies
1d1h

Yeah, that sounds like a practical approach for dealing with it. :)

shanselman
0 replies
1d2h

it's all BLE and works great on an airplane as long as BT is on

reaperman
2 replies
1d2h

Sadly it will probably receive very little consideration.

contravariant
1 replies
1d1h

There's a reason most regulations are written in blood.

BelleOfTheBall
0 replies
1d1h

While there is usually some big case that then defines things like this, I'm worried whether any incidents of a person dying or developing life-threatening issues due their phone being confiscated will change much. We've historically erred on the side of police exercising their power to enforce laws.

huytersd
0 replies
1d2h

The cops will probably deliberately keep it from you as a threat.

eitally
0 replies
1d1h

Software as a Medical Device has been a regulated "thing" for years now, and in this case the Abbott Freestyle app is a mandatory requirement for the CGM To function. If the app can't connect to the CGM, the thing will make your phone beep incessantly. Similarly, if your blood glucose levels exceed "safe" thresholds, it will alert at full volume in a way you are not allowed to override. Frankly, this is as it should be, but it does indeed convolute things when the device interface (phone) is used for so much more, too.

sdo72
10 replies
1d1h

I don't know why modern days we get so many problems wrong.

A -> B, then B -> A => incorrect

In a fire, we see firefighters, that doesn't mean firefighters cause fire. In diabetic patients, we see high glucose level. That doesn't mean eating high GI food causes someone to have diabetes.

If we look at the Blue Zone, many people eat mostly carb. So carb/high GI food definitely doesn't cause diabetes.

Devices like this will make other people fearful of high glucose and think they're getting diabetes. People without the disease shouldn't focus on monitoring the glucose level, focus on eating healthy instead. And of course eating healthy is another complex topic.

ravenstine
5 replies
20h52m

Glycemic index is only sort of useful for people who actually have diabetes, where blood sugar dysregulation makes insulin regulation equally as precarious. For anyone who doesn't have diabetes, GI doesn't really mean anything other than that their insulin may or may not spike in a short period of time related to a food. Glucose spiking, hence insulin spiking, is not something you want, but this also doesn't mean that something with a lower GI score is better for you and doesn't cause you to release as much insulin. Whether it's table sugar or whole grain pasta, they'll become glucose that the body will use or store in one way or another. Fasting glucose will still remain higher.

Devices like this will make other people fearful of high glucose and think they're getting diabetes.

Elevated glucose is exactly what causes type 2 diabetes. Take away the glucose supply, and you don't have elevated insulin. Fear of glucose that is too high too often is entirely justified and is not something that should be going on if people can avoid it. Sugar molecules are damaging to cells and are related to other things like cardiovascular calcification.

If we look at the Blue Zone, many people eat mostly carb.

So-called "Blue Zones" are not science. They are anecdotal, cherry-picked, uncontrolled, and can't be tested. Also, some of those zones, such as Okinawa, are mythical. Okinawans historically have eaten a lot of pork, and still eat a ton of pork. They also used to not keep much in the term of birth records, so there was really no way to know how old any of those people were back when they were studied.

So carb/high GI food definitely doesn't cause diabetes.

Propose a model of type 2 diabetes that doesn't involve dysregulation of blood glucose and come back to us.

sdo72
2 replies
18h56m

Every response you have don't relate to my comment! and I believe you have incorrect info in your responses as well.

ravenstine
1 replies
6h44m

Surely you have a good example of what I am incorrect about instead of merely saying I am wrong?

sdo72
0 replies
5h14m

Your comments aren't the responses to my comments. Let's take an example, my comment is neither proposing a model for T2D nor saying CGM is part of any model.

You said Okinawa people eat a ton of pork, please compare with something.

You said they don't have birth record accuracy which is not totally true. In many asian culture, they use Zodiac and similar methods to keep track of age, the exact date may be off, but the year cannot be off because if it's off, that's 12 year difference. I cannot be a dragon and claim myself to be 84 when I am only 72 because all of my friends around know how old I am around.

When 1 or 2 persons say it, it may be mythical. But when most of population say it, there must be some truth. And it's also up to you how you believe it.

462436347
1 replies
20h40m

Elevated glucose is exactly what causes type 2 diabetes. Take away the glucose supply, and you don't have elevated insulin. Fear of glucose that is too high too often is entirely justified and is not something that should be going on if people can avoid it. Sugar molecules are damaging to cells and are related to other things like cardiovascular calcification.

No, it doesn't: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602127/

ravenstine
0 replies
6h24m

Reread that article. It has literally nothing to do with cause and effect. The study finds an association between intramyocellular lipids and insulin resistance, and has absolutely nothing to say about whether diabetes is caused solely by glucose dysregulation or something else.

migro23
2 replies
1d

In a fire, we see firefighters, that doesn't mean firefighters cause fire. In diabetic patients, we see high glucose level. That doesn't mean eating high GI food causes someone to have diabetes.

This is correct but probably not in the way you think. It is not the glucose in and of itself that is the problem but the level of the hormone insulin circulating around your system that is at the root of Type II diabetes. Glucose and insulin are highly related. Insulin is released by the pancreas to help control the level glucose in our blood.

Virtually no insulin is required when metabolising fats, a small amount is required for protein and a larger amount of insulin is required when dealing with glucose dense carbohydrate based foods. The faster a carbohydrate is metabolised the greater the dose of insulin required to quell the resulting glucose rush in the blood.

What does the insulin do? As a hormone it has many functions. The presence of insulin in the blood signals to all cells to burn sugar (glucose) rather than fats (ketones) for their energy. It prompts the cells in the skeletal muscles to store up glucose in the form of glycogen for later use and it signals the liver to store excess glucose that is not immediately needed. Once the liver and muscles are full then the liver then converts any excess to triglycerides.

Where do the triglycerides go? They get stored as subcutaneous fat all over but largely in the belly (in men) and bum/upper legs (in women). What happens when subcutaneous stores are full? Then the triglycerides are shoved anywhere and everywhere. Fat is pushed into muscle cells as well as the cells in individual organs. The fat molecules present in cells in organs are particularly pernicious (visceral fat) but any cells that contain these triglycerides seems to disrupt the insulin signalling within the cell. This results in insulin resistance i.e., the ineffectiveness of insulin to signal to the cell to take up excess glucose.

When sufficient threshold of insulin resistance is reached, you will get higher blood sugar readings and a higher A1C at which point your doc will say you have prediabetes or full on type II diabetes.

Insulin is the master key variable that unlocks the type II diabetes puzzle. High blood sugar levels are just a symptom. The problem with modern day Type II diabetic care is they consider the high blood sugar as the root problem. So this is treated with meds such as metformin and eventually MORE insulin. Understanding type II diabetes as a disease of too much insulin sheds the disease in a very different light.

Anyway, you are correct, the high glucose level per se is not the cause, but high levels of insulin constantly circulating around your system is the big problem. Of course an effective way of doing that is to continuously eat foods dense in glucose and fructose that are metabolised very quickly e.g., cookies, ice-cream, orange juice etc.

If we look at the Blue Zone, many people eat mostly carb. So carb/high GI food definitely doesn't cause diabetes

Blue Zone areas such as Okinawa, you do find people eating carb rich foods but they are also high in fibre e.g., root vegetables, sweet potatoes etc. look at books by Robert Lustig to learn more about the importance of fibre in relation to metabolism and diabetes risk.

sdo72
1 replies
1d

Thank you for the detail :). And yes, I do believe lacking of fibre is one of the key important factors causing many kinds of diseases, and the modern diet is totally missing lots of fibre.

migro23
0 replies
23h55m

You're welcome. I must add that I am not a doctor so take the above with the appropriate level of skepticism on your behalf. I am only summarising what I have learned from books and have omitted A LOT of detail.

Recommended further reading

- Pure, White and Deadly (John Yudkin)

- Fat Chance (Robert Lustig)

- Outlive (Peter Attia) contains an excellent and concise synopsis of the mechanisms behind metabolic disease

462436347
0 replies
20h44m

If we look at the Blue Zone, many people eat mostly carb. So carb/high GI food definitely doesn't cause diabetes.

While obesity is known to be the greatest risk factor for T2DM, you can induce insulin resistance in weight-stable individuals just by shifting the macro composition of their diet towards saturated fat:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291812/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171936/

Sugar, amusingly, doesn't seem to have the same effect.

Given that the typical recreational CGM wearer (in my experience) is a low-carb/keto type (who ruined their insulin sensitivity), you should probably take the comments in this thread touting CGM use with a grain of salt.

gamepsys
9 replies
1d2h

I like this trend of the FDA making more and more things OTC.

reaperman
2 replies
1d2h

I haven't noticed this as a consumer in the context we're talking right now. I think that article is measuring the difference between OTC and pharmacy pricing after a drug is approved OTC. But it is not looking at prices pre- vs. post- OTC approval.

Olopatadine eye drops are amazing for allergy season, and they used to be like $250-400/bottle just 5 years ago or so, even the generic version. Then they went OTC for like $10/bottle.

This pricing difference might be true for things that are already mostly cheap, like Omeprazole -- where branding on consumer products drives OTC markup, but consumers don't pick the brand when doctors prescribe it and the pharmacy just gives them whatever cheapest generic they have in the back that they negotiated excellent pricing on.

Though you can easily close the gap on these prices by shopping for the store-brand generics at Costco, Walmart, Sam's Club, etc.

bobthepanda
1 replies
1d2h

It turns out when you strip out as much of the billing bureaucracy as possible, that things become cheaper.

reaperman
0 replies
1d1h

I think "captive market" probably contributes more than "billing bureaucracy" ... the billing is still the same issue after the generics have gotten OTC approval for doctor prescriptions filled by a pharmacist. It's still very common for doctors to prescribe, and pharmacists to fill OTC drugs, and the payments go through the same insurance company red tape as any other Rx.

And yet, the article from GP shows that the added cost of this insurance billing bureaucracy is still less than the added cost of consumer shelf-branding markups.

nickthegreek
0 replies
1d2h

For medical products though, it seems great. OTC hearing aids are a big win for society.

crakenzak
0 replies
1d1h

Is the FDA capturing any of that markup somehow? I fail to see how it would impact their decision process on approving if it had no impact on their incentives.

bobthepanda
0 replies
1d2h

“CGMs can be a powerful tool to help monitor blood glucose. Today’s clearance expands access to these devices by allowing individuals to purchase a CGM without the involvement of a health care provider,” said Jeff Shuren, M.D., J.D., director of the FDA’s Center for Devices and Radiological Health. “Giving more individuals valuable information about their health, regardless of their access to a doctor or health insurance, is an important step forward in advancing health equity for U.S. patients.”

Says nothing about it being cheaper; and honestly, taking the requirement to see a doctor out of it may end up reducing the total cost for a patient anyways.

LordKeren
0 replies
1d2h

I have an extremely hard time buying into the idea that that the reason for making glucose monitors available over the counter is simply to increase the profit margins of drug stores.

drdaeman
0 replies
23h26m

I don't get why things like CGMs require a prescription. It's just a kind of a wearable sensor. While typically only a diabetic person would need it, I fail to see any harm for any adult human if they get curious and want to stick one.

There are odd things like glasses or CPAP machine prescriptions - but at least I understand it's theoretically possible to cause some harm to oneself with those, if someone is really uneducated, reckless or stupid. With a CGM I just can't think of a sensible scenario. Except for the really stupid ones, but then a simple kitchen fork is a four times worse hazard.

RobotToaster
8 replies
1d2h

So the ones already all over amazon aren't supposed to be there?

thfuran
3 replies
1d2h

I just searched for one and found

Important information Legal Disclaimer : Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

At the very bottom of the description. That seems like complete BS that shouldn't hold up, but I don't know.

mattl
2 replies
1d1h

That's on virtually every supplement website it seems.

thfuran
1 replies
1d

Sure, but a blood glucose monitor isn't a dietary supplement. I think it's a bit dodgy that that kind of disclaimer means anything for a dietary supplement in the first place, but it certainly shouldn't apply to a medical device.

Johnny555
1 replies
1d2h

I don't see any non-prescription CGM's on Amazon, are you using Amazon USA? I searched for "CGM" and "Continuous Glucose Monitor", and only found test-strip devices and CGM devices on Amazon Pharmacy available with prescription.

What search string are you using? Can you post one?

RobotToaster
0 replies
23h30m

I was using the UK site, that probably explains it.

Usually we lag behind the USA on approvals so just assumed if it wasn't OTC there it won't be OTC here.

barelyauser
0 replies
1d2h

Amazon as a gateway to illegal or fraudulent products? Please, a trillion dollar corporation must surely have professionals watching this over.

baby_souffle
0 replies
1d1h

So the ones already all over amazon aren't supposed to be there?

In the US, I only see the finger prick type. I do see the FreeStyle Libre3 but it requires a prescription

autoexec
7 replies
1d

It'd be pretty interesting to see that kind of data, but it looks like this product violates my policy on not buying hardware that requires a cell phone app to use, and my policy on keeping as much of my medical information as far away from my mobile device as possible. I'm not sure exactly who the app itself sells/leaks the data being collected to, but even having that kind of data on the device would make me uncomfortable.

A quick read of their privacy policy suggests that the mobile app is full of personalized ads and they use your data for "direct marketing" as well as "research". They offer your data to third parties for both "marketing" and "analytics" reasons. They'll send your data overseas whenever it suits them, even to places where your data will not have the same protections, and they'll keep the data they collect forever unless you submit a request for them to delete it and they are actually required to do so by law.

Since I'm only mildly curious to see what the numbers would look like, I'm fine with waiting until someone puts one on the market that saves its data to storage that can later be copied over to an offline PC.

mlsu
3 replies
1d

They sell the data to nobody. It's considered PHI so covered by HIPAA. Dexcom has to trace custody of the data from the sensor to app to wherever it goes, so it is encrypted the whole way.

Nobody has access unless the patient wants them to.

autoexec
2 replies
1d

Their own privacy policy says they share data for marketing purposes. I don't think they'd do that without any compensation and their app includes personalized ads.

HIPAA only covers "protected health information" and not all of the data collected by their products.

They also state: "You can ask us not to use or share certain protected health information for treatment, payment, or our operations. We are not required to agree to your request"

Once a year you can also request that they send you a report on who they shared your data with and why without paying them for it, but it will not include anything involving "treatment, payment, and health care operations, and certain other disclosures (such as any you asked us to make)."

see https://www.dexcom.com/notice-of-privacy-practices

mlsu
1 replies
23h30m

I'm bet they probably do collect e.g. your phone's operating system and use that to figure out which market segment you belong to. But as far as I know Dexcom doesn't have any agreements with anyone to sell their user's data; If they have ads in the dex app I've never seen one. I would be extremely surprised if that were the case.

You can ask us not to use or share certain protected health information for treatment, payment, or our operations. We are not required to agree to your request

What they're talking about here isn't necessarily what you expect. It's that, if you e.g. encounter a bug in the product that they need to disclose to the FDA, you cannot withhold information from them that would prevent them from doing that. Or, if they need to know what kind of diabetes you have so that they can charge your insurance for the correct prescription, you can't say "you're not allowed to share that." (doesn't really apply here, but that's kind of what's meant in that clause). You can see: treatment, payment, or operations. The scope of each of those is kept as small as possible, and they do have audits from time to time ensuring that it is.

I assure you that CGM readings, trends, averages, reports, etc. ALL of that stuff is absolutely, positively considered PHI and considered extremely privileged. The only time anyone, even in the company, can see that data is if they are a customer support agent helping a specific customer, or if they are on the data science team looking at broad trends to help e.g. calibrate the product.

Once a year you can also request that they send you a report on who they shared your data with and why without paying them for it, but it will not include anything involving "treatment, payment, and health care operations, and certain other disclosures (such as any you asked us to make)."

It's because they have extra requirements around storage, retention, etc of that PHI data. It's very likely that they can't send you a report because all parties have much stricter access controls on that data so it can't be aggregated and put in a report without filing a mountain of paperwork.

I assure you, these companies do not fuck around with patient data. They don't even do things that give off the appearance of fucking around with patient data, because they know that if the HHS thinks that they are that's millions of dollars in audit costs.

chefandy
0 replies
20h5m

I'm a lot more concerned by what my insurance company can do with the data than marketing companies-- they regularly deny claims based on data collected by device vendors.

In the following article, see: Sleep aid or surveillance device?

https://www.npr.org/sections/health-shots/2018/11/21/6697510...

Maybe glucose monitoring data is different than sleep data, but I don't see why it would be. In that article, even random customer service representatives had access to his device data despite his asking them to stop storing it. I had a similar experience with a medical device that the person in the article had with their CPAP machine: I yanked a wireless modem out of the thing and stuck a flash card in there, because fuck those creeps. They sent me a very large bill retroactively denying coverage for the device for non-compliance, but luckily I didn't end up having to pay because they accepted the local data I provided without (much of) a fight. But what if the claim wasn't for a comparatively inexpensive machine, and it was for an inpatient medical procedure with surgery, lots of imaging, and a 10k ambulance ride? You better fucking believe I'm not going to voluntarily help them weasel out of coverage.

spc476
1 replies
1d

My girlfriend as the Libre 3, and she has both the cell phone app, and a stand alone unit to store results. You can only use one or the other, not both at the same time (the Libre 3 uses Bluetooth). We have the stand alone unit because of insurance reasons.

xen2xen1
0 replies
23h48m

Dexcoms also have small cell phone like devices you can use. I've never put a wifi password in I can recall.

bsilvereagle
0 replies
16h44m

For the Freestyle Libre 3, you can use it without an account. That does not mean that Abbott is not still sending your readings to the cloud, but at least your name is not attached to it.

It takes some work, but you can "liberate" your data from the app without the cloud account: https://frdmtoplay.com/freeing-glucose-data-from-the-freesty...

post_break
6 replies
1d2h

Can we do CPAP machines next?

polishdude20
3 replies
1d2h

Technically you can buy them on Facebook marketplace, craigslist etc

akulbe
1 replies
1d2h

Not really. It's against ToS in both cases, to sell used medical equipment.

bookofjoe
0 replies
1d2h

Yet renting medical equipment is a flourishing business, at least in the U.S.

asow92
0 replies
1d2h

Something about a used CPAP machine raises my yuck alarm

electriclove
0 replies
1d

And contact lenses too!

dumbfounder
0 replies
1d2h

I had to buy one for a friend. But then he ordered a new one and all he had to do was send them a picture of his old one (after some persistence). It’s ridiculous.

lacoolj
5 replies
1d2h

inb4 apple watch integration

bradleyy
2 replies
1d

Dexcom already has an integration; are you talking about hardware?

mattl
1 replies
1d

Yeah, it would be great if the watch could just do this for you, instead of needing to buy a new sensor every 14 days.

thecosas
0 replies
23h8m

Based on everything I've seen so far, the technology for non-invasive glucose monitoring is still far away. Recently, the FDA even released a warning that any companies claiming they could are misleading people [1][2].

Don't get me wrong; I have had T1D for 30+ years and would love to have reliable, non-invasive, glucose monitoring on my wrist.

We've come so far already from a finger stick that would take 2 minutes to get a result. Have hope :-)

[1] https://www.fda.gov/medical-devices/safety-communications/do...

[2] https://www.theverge.com/2024/2/21/24079495/smartwatch-smart...

asow92
1 replies
1d2h

I'll be buying that apple watch if it ever gets here

csours
5 replies
1d2h

I wish Theranos had worked on a more reasonable goal - like an implantable CGM.

I had T2D, well controlled now, my A1C is below the diabetic diagnostic range.

I used CGMs, and they taught me a lot about how my body reacted to food and exercise.

But I sweat a lot and they would always fall off, halving the useful life of each monitor. I would probably still use them from time to time if they didn't sweat off; and if an implantable version was available for a reasonable price (under $500, with no ongoing costs), I'd probably get it.

I feel like a lot of prediabetic people could learn a lot about their situation with this. I think this is a very good thing.

guidopallemans
3 replies
1d1h

I used to have this problem as well, so I talked it over at my endo office. They suggested that I order some specially shaped stickers to keep them on, but instead I just bought some Kinesiology Tape (hansaplast, but also exists store-brand). 10cm of that works perfectly, even for heavy contact sports combined with sweating (and many showers).

csours
1 replies
1d

Yup, I tried this. I sweat A LOT

crimsontech
0 replies
23h55m

I tried different tapes, Kinesiology tape didn’t stick for me but Hypafix did, I can’t get this stuff off without soaking it.

If you ever want to give it another go, try Hypafix. I tore my skin the first time and quickly learned to soak it and use soap to remove the GCM.

mapkkk
0 replies
1d1h

Just make sure you cut a small circle from the tape overlying the breather hole of the sensor - that hole serves to let moisture buildup from underneath the sensor escape.

T1DTech
0 replies
23h30m

Eversense is implantable, but you have to have a healthcare provider insert it and remove it. So mini surgery every six months. I'll pass.

thecosas
4 replies
1d

T1D here who has been using Dexcom G6 for many years now. Interesting to see the differences between Stelo and G7 which are built on the same platform.

Curious if anything is driving the increase in wear time other than battery life savings from reporting back fewer readings.

  CGM:                   G7 / Stelo
  Wear time:             10 / 15 days
  Time between readings:  5 / 15 minutes

user_7832
1 replies
1d

I seem to remember there was a "trick" with the g6 where you remove and reinsert the transmitter to get it to last longer... I suspect the time estimates are quite conservative.

thecosas
0 replies
23h54m

Yep, I've definitely used my G6 for two sessions using "tricks". It would definitely get wonky towards the end of that time period, but it worked.

jonlucc
1 replies
1d

I'm not sure how much I can say; I don't work for a CGM company, but my company is very interested in diabetes. There are non-device reasons you can't use a CGM indefinitely. The site becomes less reliable over time, and it varies from peron to person. I'm not sure if the Stelo has addressed any of those, or if the G7 was overly cautious, or something else, but there are biological things happening at the site that affect the time too.

thecosas
0 replies
22h56m

Ah, that makes sense. I'm certain we'll never "know" but just found it interesting and was curious if people knew other trade-offs they may have been making for increased wear time, especially given that would offer a sharp reduction in cost over time for patients (and their insurance companies, etc).

A 50% increase in wear time is HUGE in my opinion.

patsplat
4 replies
21h8m

I just heard about a related device from a family member who is an endocrinologist.

https://www.fda.gov/news-events/press-announcements/fda-clea...

First off, he had discomfort with the study methodology. Didn't go into details, but was surprised that the FDA was less conservative than himself in this case.

Secondly, it has been common in his practice for someone to have an unusual event. Someone does something out of the ordinary, they have an unusual circumstances, they don't adjust their treatment, and something goes wrong.

His question was -- does the device have a reset button? Is there a way to restart the management and learning? The answer is no -- the device will learn! But there's no way for the patient or the physician to adjust the treatment. So his answer is -- he would never recommend this device, not the way it's currently setup. It's opaque and there's no means for a person to influence the device's learning.

TylerE
2 replies
21h5m

This is just monitoring, not a pump. There is no learning or tuning or dosing. If it’s anything like the Freestyle I wore for a while there’s a self calibration process that takes a couple hours, but that’s per-sensor, and those get changed out every two weeks.

TylerE
0 replies
19h9m

I will point out the obvious tensions between these legitimate concerns and the usual HN "we demand full unfettered access to all the firmware knobs all the time" groupthink.

xattt
0 replies
21h3m

But there's no way for the patient or the physician to adjust the treatment.

This does not parse. This device is for patients that are managed with oral meds and not insulin. Yes, sulfonylureas carry some risk of hypoglycemia, but not as much as insulin proper and its fast- and slow-acting friends.

If someone is on a pump, they sure as heck will be using prescribed equipment.

briandw
3 replies
22h14m

I did this for fun using the veri.co service. It was interesting how little my diet immediately affected my blood sugar. Non diet things were much bigger. Do hard exercise -> spike. Take a hot shower -> spike. Fast for 48 hours -> blood sugar still rises in the morning.

Walking was by far the most effective way to keep blood sugar down after a meal.

Most of what I ate didn't cause a problem. However tend avoid sugar and carbs. The worst offender was a PB&J sandwich. That was surprising.

eep_social
1 replies
6h2m

hot shower -> spike

Assuming this was a Libre, this is likely reader inaccuracy that does not reflect an actual blood glucose event.

briandw
0 replies
2h19m

That makes sense and I was wondering if it might be related to the device temp. I should have tried putting a hot pack on the sensor to validate.

int_19h
0 replies
17h2m

Both peanut butter and jelly have lots of sugar in them. Modern supermarket bread (in US) usually does, as well, and the carbs in it also turn into sugar quite readily right in your mouth.

moralestapia
2 replies
1d1h

Great news. Reading through their website and just found out they're disposable(!).

Anyone knows if there's a reason for this? I don't want to think is just a money grab. Perhaps the patch wears off?

mapkkk
0 replies
1d1h

The patch does wear off but the main reason is because there's a finite amount of enzyme (glucose oxidase) on the filament that does the actual glucose measurement on the sensor. So over time the enzyme is "spent". That, and of course it's lucrative. There are clever ways people have come up with (particularly from low income regions) where you can trick these sensors or the apps to reset and apparently you can get way longer lifespans like that (for the dexcom you also have to file down the bluetooth transceiver so that you can get at the battery within) at the risk of no longer being able to trust the readings.

There's one company that's experimenting with an implantable CGM that will supposedly have a 6 month lifespan, with a bluetooth powered patch that you apply on the skin overlying the implant.

coldcode
0 replies
1d1h

All CGMs only work for a period of time, like a couple of weeks or so. Then you get a new one. To keep the size reasonable it can't be too big.

dansitu
2 replies
1d

If you find this field interesting, Know Labs is working on a non-invasive continuous glucose monitor using RF spectroscopy:

https://www.knowlabs.co

huytersd
1 replies
1d

Non invasive would be a golden goose. I don’t think I want to have something sticking into my skin for weeks on end.

teleforce
0 replies
18h45m

This is a promising non invasive glucose sensor namely GlucoRx Wearable BioXensor using microwave technique [1]. For the technical background how the sensor work and the clinical trials results please check this paper (paper also available from their university website) [2].

[1] Meet the inventor: Professor Adrian Porch from Cardiff University:

https://www.med-technews.com/medtech-insights/latest-medtech...

[2] Microwave Noninvasive Blood Glucose Monitoring Sensor: Human Clinical Trial Results:

https://ieeexplore.ieee.org/document/8058721

UI_at_80x24
2 replies
22h38m

It's worth mentioning that in Canada, you do not require a prescription to get a CGM. However only the Abbot Freestyle Libre series is available here. It cost ~$100 and last 2 weeks.

I've found it to be mostly accurate.

Placing it on the back of the arm was always a problem for me, it was constantly getting knocked/pulled, and otherwise disturbed. I had to buy adhesive patches that covered the entire unit. I later discovered that another decent place to apply them in on my chest between my collar-bone and shoulder-joint but lower (towards the nipple). I always had decent reliability/accuracy there. It also hurt less (from the adhesive) then on the back of the arm.

Having a CGM is amazing, and if you have medical coverage that will pay for it then you should get it.

elevaet
1 replies
22h35m

Can you give the elevator pitch on why someone should get one?

UI_at_80x24
0 replies
21h49m

With a CGM you always can know what your instantaneous, average and trending blood glucose readings are. With a test-strip you know your instantaneous reading are. With a test strip, a pad of paper, a calculator, a calendar, a watch, and a good enough memory to take reading 100+ times a day you can get the same results.

With the test strips, I measured myself AT MOST, 7 times a day. Often just once or twice.

THAT is what makes them worthwhile. It keeps measuring so you don't have to.

One helpful thing that I don't worry about: Low blood sugar alarms. Hypoglycemia is a real concern, and just as serious as hyperglycemia. A CGM will alter you when your sugar gets too high OR too low.

I'm poor. I can't afford a CGM anymore. So I have been going months now without measuring. Because I keep forgetting. A CGM doesn't have that limitation.

I was really hoping that Apple was going to announce a CGM. I avoid the Apple ecosystem, but I would have invested in that.

005
2 replies
1d2h

I don't think this is particularly special. In other countries it's possible to obtain Dexcom's current line up by purchasing it online (G6, ONE, G7) and other brands too like Abbott's Freestyle Libre.

It seems like this is a stripped down version of the G7 (albeit with a longer wear time) as the ONE is a stripped down version of the G6.

ethanbond
1 replies
1d2h

"In other countries"... right... opening it up to a market of 340 million people with rampant metabolic problems is what's special about it.

m3kw9
0 replies
20h48m

80$ a pop for 2 weeks and most people cannot access it long enough

dddiaz1
1 replies
1d2h

Great to see it be OTC. But it's weird that it is advertised to last for 15 days, while the prescription version for T1ds/T2ds only lasts for 10 days. The hardware looks the same.

chx
1 replies
1d1h

I got the dexcom g6 three years ago via a simple online order in Canada. Is Canada more lax? What's the difference?

coldcode
0 replies
1d1h

In the U.S., until this one, you needed a prescription to buy one. Many countries allow them to be purchased without.

FigurativeVoid
1 replies
1d1h

I'm a T1 diabetic, and CGMs are a great tool for blood sugar management. Combined with a closed loop system, they are literally life changing.

I am glad to see an increase in access to live changing medical care for a disease that is mostly just bad luck.

thecosas
0 replies
23h38m

T1D here too. Fun to see others having an interest in CGMs :-)

zxienin
0 replies
1d

I use Abbott Freestyle Libre 3 and it has been deeply insightful about my progress with T2D. An increase in fasting glucose over 2-3 days tells me I need course correction (more movement, choice of food). I also noticed consistent correlation between bad sleep days and raised glucose levels over the day. Made me internalize how important sleep is.

I believe, next major uptick will come from CGM in wearables like Apple/Samsung watches [1][2]. I hope, even non diabetic folks use it to improve their health.

[1] https://www.macrumors.com/2023/09/14/apple-watch-blood-gluco... [2] https://www.macrumors.com/2024/01/23/samsung-racing-to-beat-...

thecosas
0 replies
23h34m

Just noticed this line in the press release from Dexcom [1]:

  Stelo will be available for purchase **online** without a prescription starting summer 2024.
I wonder if that means that this will be direct-to-consumer in addition to retail channels (CVS, RiteAid, Amazon, etc).

[1] https://investors.dexcom.com/news/news-details/2024/Stelo-by...

terhechte
0 replies
1d2h

I bought a Sibionics GS1 recently and am about to use it (SIBIONICS GS1 Sensor Continuous... https://www.amazon.de/dp/B0CPDHKGYK?ref=ppx_pop_mob_ap_share). Reading this thread I’m wondering if it is a safe / good product to use. Does anybody happen to have knowledge?

squirrel6
0 replies
21h14m

I have been doing CGM for 7 months now and the learning has been invaluable. My metrics were never in the danger zone but I feel like I’ve learned so much about how many different factors play into insulin resistance and have managed to build much healthier habits over time.

phasetransition
0 replies
7h38m

My 3 year old has type 1, and CGM has kept us out of the ER for surprise lows multiple times.

It also has informed family diet change, in the direction of keto practices, that has compressed the baseline to high delta for our son.

It's a relief to know that an OTC product exists as a backstop to our prescription CGMs.

nobrains
0 replies
14h59m

A family member uses Abott Freestyle libre 2 CGM and buys it OTC. In UAE.

metabagel
0 replies
23h15m

I put something like this on my cat, because the vet thought she may be pre-diabetic, but stress response can also cause blood sugar to spike, so we needed to see what her blood sugar was like multiple times per day.

The device worked for 5 days until she had managed to dislodge it enough so it wouldn't get a reading. The skin glue lasted another 5 days before the device fell off. Since then, she has had a "crop circle" behind her shoulder where her fur was shaved away, and which is ever so slowly filling in.

Her readings were fine, so we are feeding her low carbohydrate food, because the vet thinks she may become diabetic in the future.

Unfortunately, I had to place the reader device almost directly on the sensor, which was a pain, because my cat likes to hide under the bed. So, I had to squirt her with water to get her out, which was undesirable, but didn't seem to affect the readings.

The device was the Freestyle Libre 2.

https://www.freestyle.abbott/us-en/products/freestyle-libre-...

maxehmookau
0 replies
12h29m

I'm gonna go against the grain here and say that I tried a CGM for a few months and found it fairly unhelpful. (I'm not diabetic.)

Yeah, eating stuff that's bad for me caused a blood sugar spike and made me feel crummy. Eating healthier foods did not cause the same spike and I felt better.

I didn't need to spend money to tell me that.

lhl
0 replies
23h26m

I’d highly recommend anyone considering trying one out to give it a pin. I’ve used a CGM multiple times besides being a great feedback mechanism, it also can give you really interesting insights. Here’s one interesting tidbit showing that having an ice cream cone in between an hour-long walk actually caused no postprandial glucose spike compared to an earlier “healthy” meal served with no activity (at a metabolic health conference) https://fediverse.randomfoo.net/notice/Aafczv5LO83OOwXrbU

komposit
0 replies
10h24m

My son was diagnosed with diabetes about 4 weeks ago. The first two weeks we were measuring him through fingersticks multiple times daily. Now we have the cgm it has become so much easier to manage his condition.

The interesting thing to observe is to see in real time the metabolic spectrum of the foods we consume. Liquid sugars cause glucose spikes within 6 minutes. Solid carbs 30-120 minutes depending on carb complexity etc. Proteins 3h+. Fats can be six hours or more.

The thing is there are a variety of insulins available, some of which are rapid acting and others act more slowly. So to keep my son in range with multiple daily injections you are playing this game of giving him the right mix of foods where his carb digestion matches the profile of his rapid acting insulin.

Pizza is an interesting case study. It is by far the most carb rich deal we've tried and it is almost impossible to manage. With so many carbs it's hard to get the insulin dosage right, and once he is high, once he is coming down from that the digestion of the fats kicks in and he remains high through the night.

I think it would be a great thing for people to wear even just for a couple of weeks.

jesprenj
0 replies
22h14m

For having participated in a study, they installed an Abott FreeStyle Libre 2 sensor on me for 14 days. I could get minute readings, which is not possible with either the hardware reader nor the official app, using the almost entirely FOSS android app Juggluco.

Another FOSS web tool is Nightscout -- it generates reports and live graphs from data gathered from your CGM via for example Juggluco. My instance is at http://sladkor.4a.si. My sensor expired, so there's no more live data.

glucometerutils is an interesting repo for downloading stored data from hardware readers etc. Abott encrypted the Libre 2 USB communication to force users to use their proprietary software, but hackers managed to extract keys.

http://juggluco.nl http://nightscout.github.io https://github.com/glucometers-tech/glucometerutils http://ni.4a.si./anonymous/freestyle-keys/tree/freestyle_key...

jablongo
0 replies
18h17m

This is great news for the healthcare system because it is going to drive down costs for people with diabetes who really need these things. Well done Dexcom!

This OTC model limits the measurements to every 15 mins instead of every 5 for the prescription version; this will limit its ability to be integrated into open source automated insulin delivery systems. Not sure why they made this choice as the hardware looks the same as the Dexcom G7. In theory they could be doing it to increase battery life or allow for cheaper batteries to be used in the consumer version.

ijustlovemath
0 replies
18h12m

Glucose control is my particular area of expertise; if anyone has any questions about it, I'm happy to be a resource!

henrikberggren
0 replies
21h36m

I've been wearing one for 6 years straight and wrote a post back in 2018 when I first got one. As someone who lives with Type 1 diabetes its been one of the absolute biggest game changers for my health

https://blog.steady.health/the-wearable-that-changed-my-life...

I also started a company focused on CGMs which was too early and didn't work. Maybe its time to try again? :)

gumby
0 replies
1d2h

Hopefully they are cheaper than the copay on the Libre 3 sensors.

galago
0 replies
1d1h

I'm currently wearing the Freestyle Libre 3. It communicates with the app every minute. I have something between pre-diabetes and diabetes so I have a slight chance at being able to treat my condition with diet/weight/exercise. Its definitely changing my behavior--I'm aware that it is not as accurate as the stick test but I have a plot of my blood sugar throughout the day. Currently I'm consuming very little carbohydrates. I've learned from my own data what foods will cause my blood sugar to spike.

The app is missing some obvious features, and people are right to complain, but its way better it seems than devices that came before.

fgkramer
0 replies
1d

I’m currently wearing a CGM from Lingo (https://www.hellolingo.com/) which is pretty much the easiest way I’ve found to get my hands on one without a prescription (as I’m not diabetic).

So far it’s shown me that the sluggishness after a carb-heavy meal its heavily correlated with the glucose spike and how good my organism copes with it.

Can’t wait for the day we have our own Fallout style Pip-Boys!

davidthewatson
0 replies
21h59m

I'm happy for those who have been helped by these devices.

The FDA approval is only a revelation to the extent that the hidden truth of the extant prescription CGM market is poor data veracity combined with high catastrophic failure of the devices under manufacturer warranty in some patients.

It's difficult to know for sure the size of the patient cohort impacted here since these numbers are not made public. If the market functioned transparently, this knowledge would be of great benefit to consumers.

Given the proprietary nature of these organizations, and the fact that they spend lots of money on lobbyists and lawyers to maintain the status quo, I'm not expecting this to get better, at least in the United States. This leaves the hope that the EU or elsewhere may be more aggressive in regulation, as they have demonstrated recently around Apple and Google.

LSS: there's a ton of room for competition, cooperation, and innovation in CGM's and their slowly evolving ecosystem of software, smart phones, and smart watches, particularly in open source where hacks frequently work around the proprietary limitations in software, i.e. information devices that have little to do with telling time save for putting a date/time stamp on their event stream which is nowhere near the 5 V's of big data in volume, velocity, or veracity.

The two leaders in the space, Dexcom and Abbott both fail at a high rate with some individuals, such as me. Turns out that at the edges, adipose tissue and its interstitial fluid are a poor proxy to plasma blood glucose in some individuals. This is likely due to fluctuations in the composition of that tissue during times of fasting: exercise and sleep.

Sadly, the price of admission for my family has been high given that no one has slept normally for five years with the screeching alarms nightly at 3 AM, which are not adequately configurable. The design failure here is clearly driven by liability.

It's worth considering that the brain's default mode network (DMN) is impacted by glycemia. This has been demonstrated via an fMRI lab at Harvard via Nicolas Bolo, et al using a small cohort of diabetics.

The leap from there to what families of diabetics have known intuitively for decades may be phenomenological, but it isn't difficult.

Put simply: diabetic mood swings may not give rise to psychosis, but the mood dynamics of glycemia have been clear for almost as long: a spectrum from hypomania or nightmares induced by hypoglycemia to hyper compulsivity or depression induced by hyperglycemia.

I'm not certain that a researcher or clinician like Bolo exists to put data behind these glycemic mood associations, but speculatively, the relationship is clear to me from a subjective metacognition perspective, as someone who's been T1D for ~50 years and also has an HbA1c below the diagnostic threshold for T1D and routinely stays functional with accurate plasma BG < 50 and shows no signs of cognitive impairment accruing to these brain states after various neurology studies.

It's worth noting that hypoglycemia itself is a dynamic range, not a constant, and is frequently lower for people who have eaten or trained on the ketogenic spectrum, i.e. ultra marathon runners like Zach Bitter.

My experience has been that the feelings associated with hypoglycemia can be paradoxically awful at BG=80 and no problem at BG=40. If you've never eaten a half gallon of ice cream yourself with no signs of obesity, then you may not understand the zen state it takes to overcome this "beyond hunger" that's immediately familiar to any experienced diabetic on earth, while recognizing that that problem does not occur naturally with the disease. It's the result of insulin overdose, carbohydrate under-supply, or both.

FWIW, Microdosing carbohydrate may be key.

I believe the first use of the term in science was actually in glucagon, IIRC, i.e. the need for yet another syringe of glucagon in emergent insulin pumps that would go beyond the current crop of devices that are near autonomy, but may inadvertently overdose or underdose the patient due to the poor veracity of CGM sensors across the board and the hybrid closed loop devices which dose based on CGM which may be demonstrably inaccurate on occasion to the tune of several hundred points off high and low.

I have n-of-1 empirical evidence of this given the fact that I wore several insulin pumps for twenty five years and used multiple CGMs over that time, some concurrently. All were what we call, "shipping the prototype". Fortunately, beyond Therac 25, that was not an option in other medical device markets; certainly not those under FDA oversight.

daveisfera
0 replies
23h22m

I haven't seen price info anywhere, but anyone have info on what that will be?

darreninthenet
0 replies
1d

My wife already buys a Libre Freestyle over the counter here in the UK... are we talking the same thing? Why are (or were) they prescription only in the US..?

cooldevguy
0 replies
22h29m

I am diabetic type 2 and I've used the Abbot Freestyle Libre 2 for a few years now. You don't need a prescription in Mexico to get it, but it is expensive ($1548 MXN ~= $91 USD). The data you get is pretty interesting but at least on my experience, the difference between readings from the CGM and actual blood test can vary from 10 ~ 40 mg/dL so you have to have that in mind. However it was really helpful to discover that, while I'm pretty active since a few years ago it was troubling for me to wake up on readings over 140 mg/dL which thanks to this turned out to be just that my body does it naturally and my blood sugar spikes while asleep and an hour or so before I wake up, which my endocrinologist just attributes to my body getting ready to work out.

Even as an experiment, I'd say most people should get one just to understand their bodies, and their specific responses to certain foods, once in a while.

arisbe__
0 replies
17h20m

This could lead to a large amount of helpful preliminary signals that eventually pan out into some new knowledge.

apatheticonion
0 replies
22h51m

I currently sticky-tape my Fitbit Inspire 3 to my tricep to get continuous low effort health/sleep tracking.

I used sticky tape as an experiment because there are no arm bands for Fitbit products. That was a year and a half ago and have worn it like that every day since.

I can't wait until trackers can be implanted under the skin, track blood glucose, and improved accuracy.

Let's gooooo

antirez
0 replies
12h47m

I'll be that guy to say that if you don't have a diabete problem, you don't need a CGM: here in Italy there is this crazy fashion of wearing one if you are into sports or alike. It's much better to eat clean, check your weight, and don't care about your physiological parameters all the times.

alexnewman
0 replies
1d

CGM is cool but it interferes with my ability to swim in the ocean on the reg

NoPicklez
0 replies
22h23m

These are so interesting and not just for diabetics who benefit from them the most.

Top athletes have been using them for exercise to make sure their blood sugar remains in the correct ranges.

But Diabetics are using them to help identify how particular foods impact their blood sugar levels (obviously). The reason being is that whilst some foods might be considered high/low in sugar, each of us reacts differently in how we absorb those foods or drinks. So a bagel you eat might not spike your blood sugar like someone else, or conversely it does. You can then correlate that spike or reduction in blood glucose with how you're feeling throughout the day, how your blood sugar levels impact exercise.

Also it allows you to see how combinations of foods and the order that you eat them in impacts blood sugar. If you eat a chunk of white rice without any fibre you might find it spikes, if you each a bunch of vegetables in the bowl before hand you might find it doesn't rise as high or give you a steadier release of blood sugar.

I'd use one for a few months just to see how foods impact my blood sugar and how I can make different choices. It's one thing to interpret a label, but it's another to see it's impact on your body in real time.

NelsonMinar
0 replies
1d1h

So glad to see medical monitoring made available to people. Different problem but an O2Ring continuous blood oxygen monitor was a big help to me in understanding my sleep apnea and getting it treated.

JoeAltmaier
0 replies
5h33m

Some of us can't be trusted with continuous stat reporting. I hit Update on HN often enough. I don't even wear a watch, I kept looking at it every twenty seconds and then realized I still didn't know what time it was, it was just a reflex.

I learned to leave my phone someplace else, upstairs, wherever, just check it a couple times a day. Else I'd go crazy.

I took the speedometer off my bike, I was looking at it more than the road.

So I understand my limits and take steps to keep my self from compulsive behaviors. I guess(?) other people do better and can handle these things.

EMCymatics
0 replies
1d1h

It can help your health but I'm concerned how often the data will get abused.

AbstractH24
0 replies
14h42m

From what I understand, the next step after this is a device that continuously measures ketones as well.

Very interested in that

99112000
0 replies
22h6m

I got some FreeStyle Abotts for anyone who wants to hack away at them. Rumor has it Dexcom is cheaper in bulk than Abotts and they are losing hospitals as customers.